Gene regulation and signaling transduction in mediating the self-renewal, differentiation, and apoptosis of spermatogonial stem cells
Infertility has become one of the most serious diseases worldwide, and 50% of this disease can be attributed to male-related factors. Spermatogenesis, by definition, is a complex process by which spermatogonial stem cells (SSCs) self-renew to maintain stem cell population within the testes and diffe...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2025-01-01
|
| Series: | Asian Journal of Andrology |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/aja202467 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850074860793888768 |
|---|---|
| author | Cai-Mei He Dong Zhang Zuping He |
| author_facet | Cai-Mei He Dong Zhang Zuping He |
| author_sort | Cai-Mei He |
| collection | DOAJ |
| description | Infertility has become one of the most serious diseases worldwide, and 50% of this disease can be attributed to male-related factors. Spermatogenesis, by definition, is a complex process by which spermatogonial stem cells (SSCs) self-renew to maintain stem cell population within the testes and differentiate into mature spermatids. It is of great significance to uncover gene regulation and signaling pathways that are involved in the fate determinations of SSCs with aims to better understand molecular mechanisms underlying human spermatogenesis and identify novel targets for gene therapy of male infertility. Significant achievement has recently been made in demonstrating the signaling molecules and pathways mediating the fate decisions of mammalian SSCs. In this review, we address key gene regulation and crucial signaling transduction pathways in controlling the self-renewal, differentiation, and apoptosis of SSCs, and we illustrate the networks of genes and signaling pathways in SSC fate determinations. We also highlight perspectives and future directions in SSC regulation by genes and their signaling pathways. This review could provide novel insights into the genetic regulation of normal and abnormal spermatogenesis and offer molecular targets to develop new approaches for gene therapy of male infertility. |
| format | Article |
| id | doaj-art-d9bcb8dcb9214f06ae3e1397aa7e9bb3 |
| institution | DOAJ |
| issn | 1008-682X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Asian Journal of Andrology |
| spelling | doaj-art-d9bcb8dcb9214f06ae3e1397aa7e9bb32025-08-20T02:46:28ZengWolters Kluwer Medknow PublicationsAsian Journal of Andrology1008-682X2025-01-01Gene regulation and signaling transduction in mediating the self-renewal, differentiation, and apoptosis of spermatogonial stem cellsCai-Mei HeDong ZhangZuping HeInfertility has become one of the most serious diseases worldwide, and 50% of this disease can be attributed to male-related factors. Spermatogenesis, by definition, is a complex process by which spermatogonial stem cells (SSCs) self-renew to maintain stem cell population within the testes and differentiate into mature spermatids. It is of great significance to uncover gene regulation and signaling pathways that are involved in the fate determinations of SSCs with aims to better understand molecular mechanisms underlying human spermatogenesis and identify novel targets for gene therapy of male infertility. Significant achievement has recently been made in demonstrating the signaling molecules and pathways mediating the fate decisions of mammalian SSCs. In this review, we address key gene regulation and crucial signaling transduction pathways in controlling the self-renewal, differentiation, and apoptosis of SSCs, and we illustrate the networks of genes and signaling pathways in SSC fate determinations. We also highlight perspectives and future directions in SSC regulation by genes and their signaling pathways. This review could provide novel insights into the genetic regulation of normal and abnormal spermatogenesis and offer molecular targets to develop new approaches for gene therapy of male infertility.https://journals.lww.com/10.4103/aja202467fate decisionsgene regulationmale infertilitysignaling transduction pathwaysspermatogonial stem cells |
| spellingShingle | Cai-Mei He Dong Zhang Zuping He Gene regulation and signaling transduction in mediating the self-renewal, differentiation, and apoptosis of spermatogonial stem cells Asian Journal of Andrology fate decisions gene regulation male infertility signaling transduction pathways spermatogonial stem cells |
| title | Gene regulation and signaling transduction in mediating the self-renewal, differentiation, and apoptosis of spermatogonial stem cells |
| title_full | Gene regulation and signaling transduction in mediating the self-renewal, differentiation, and apoptosis of spermatogonial stem cells |
| title_fullStr | Gene regulation and signaling transduction in mediating the self-renewal, differentiation, and apoptosis of spermatogonial stem cells |
| title_full_unstemmed | Gene regulation and signaling transduction in mediating the self-renewal, differentiation, and apoptosis of spermatogonial stem cells |
| title_short | Gene regulation and signaling transduction in mediating the self-renewal, differentiation, and apoptosis of spermatogonial stem cells |
| title_sort | gene regulation and signaling transduction in mediating the self renewal differentiation and apoptosis of spermatogonial stem cells |
| topic | fate decisions gene regulation male infertility signaling transduction pathways spermatogonial stem cells |
| url | https://journals.lww.com/10.4103/aja202467 |
| work_keys_str_mv | AT caimeihe generegulationandsignalingtransductioninmediatingtheselfrenewaldifferentiationandapoptosisofspermatogonialstemcells AT dongzhang generegulationandsignalingtransductioninmediatingtheselfrenewaldifferentiationandapoptosisofspermatogonialstemcells AT zupinghe generegulationandsignalingtransductioninmediatingtheselfrenewaldifferentiationandapoptosisofspermatogonialstemcells |