Long-term tumor suppression in cholangiocarcinoma using cytokine-induced killer cell therapy and high-dose vitamin C: a case report
This case study explores the effectiveness of autologous cytokine-induced killer (CIK) cell-based immunotherapy in a 49-year-old male patient with inoperable stage IIIb cholangiocarcinoma, characterized by high levels of the sodium-dependent vitamin C transporter-2 (SVCT2) in immune cells. Despite a...
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| Format: | Article |
| Language: | English |
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Korean Society of Surgical Oncology
2024-12-01
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| Series: | Korean Journal of Clinical Oncology |
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| Online Access: | http://www.kjco.org/upload/kjco-20-2-84.pdf |
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| author | Kangseok Kim Hyunhye Wang Jiewon Lee Changhwan Yeom |
| author_facet | Kangseok Kim Hyunhye Wang Jiewon Lee Changhwan Yeom |
| author_sort | Kangseok Kim |
| collection | DOAJ |
| description | This case study explores the effectiveness of autologous cytokine-induced killer (CIK) cell-based immunotherapy in a 49-year-old male patient with inoperable stage IIIb cholangiocarcinoma, characterized by high levels of the sodium-dependent vitamin C transporter-2 (SVCT2) in immune cells. Despite an initial lack of tumor reduction following chemotherapy, the patient showed a significant decrease in tumor markers and stabilization of the tumor after undergoing radiation and proton therapy. Subsequently, CIK cell therapy, combined with high-dose vitamin C, was administered 52 times over 6 years. The patient’s tumor size reduced, and no cancer activity was detected for 7 years and 10 months post-diagnosis, indicating a successful long-term outcome without recurrence. This study suggests that CIK cell therapy, particularly in patients with elevated SVCT2 levels, may offer a promising adjuvant treatment for cholangiocarcinoma and potentially other cancers. Further research is needed to validate SVCT2 as a biomarker for the effectiveness of CIK cell therapy. |
| format | Article |
| id | doaj-art-d9bb92fc7fa548d184c817c6b8b424e2 |
| institution | OA Journals |
| issn | 1738-8082 2288-4084 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Korean Society of Surgical Oncology |
| record_format | Article |
| series | Korean Journal of Clinical Oncology |
| spelling | doaj-art-d9bb92fc7fa548d184c817c6b8b424e22025-08-20T02:28:16ZengKorean Society of Surgical OncologyKorean Journal of Clinical Oncology1738-80822288-40842024-12-01202848710.14216/kjco.24012427Long-term tumor suppression in cholangiocarcinoma using cytokine-induced killer cell therapy and high-dose vitamin C: a case reportKangseok Kim0Hyunhye Wang1Jiewon Lee2Changhwan Yeom3 Department of Surgery, Bangre Hospital, Incheon, Korea Department of Radiology, Bangre Hospital, Incheon, Korea Department of Family Medicine, Yeom Chang Hwan Hospital, Seoul, Korea Department of Family Medicine, Yeom Chang Hwan Hospital, Seoul, KoreaThis case study explores the effectiveness of autologous cytokine-induced killer (CIK) cell-based immunotherapy in a 49-year-old male patient with inoperable stage IIIb cholangiocarcinoma, characterized by high levels of the sodium-dependent vitamin C transporter-2 (SVCT2) in immune cells. Despite an initial lack of tumor reduction following chemotherapy, the patient showed a significant decrease in tumor markers and stabilization of the tumor after undergoing radiation and proton therapy. Subsequently, CIK cell therapy, combined with high-dose vitamin C, was administered 52 times over 6 years. The patient’s tumor size reduced, and no cancer activity was detected for 7 years and 10 months post-diagnosis, indicating a successful long-term outcome without recurrence. This study suggests that CIK cell therapy, particularly in patients with elevated SVCT2 levels, may offer a promising adjuvant treatment for cholangiocarcinoma and potentially other cancers. Further research is needed to validate SVCT2 as a biomarker for the effectiveness of CIK cell therapy.http://www.kjco.org/upload/kjco-20-2-84.pdfcell therapysodium-dependent vitamin c transporter-2ascorbic acidcholangiocarcinomacase reports |
| spellingShingle | Kangseok Kim Hyunhye Wang Jiewon Lee Changhwan Yeom Long-term tumor suppression in cholangiocarcinoma using cytokine-induced killer cell therapy and high-dose vitamin C: a case report Korean Journal of Clinical Oncology cell therapy sodium-dependent vitamin c transporter-2 ascorbic acid cholangiocarcinoma case reports |
| title | Long-term tumor suppression in cholangiocarcinoma using cytokine-induced killer cell therapy and high-dose vitamin C: a case report |
| title_full | Long-term tumor suppression in cholangiocarcinoma using cytokine-induced killer cell therapy and high-dose vitamin C: a case report |
| title_fullStr | Long-term tumor suppression in cholangiocarcinoma using cytokine-induced killer cell therapy and high-dose vitamin C: a case report |
| title_full_unstemmed | Long-term tumor suppression in cholangiocarcinoma using cytokine-induced killer cell therapy and high-dose vitamin C: a case report |
| title_short | Long-term tumor suppression in cholangiocarcinoma using cytokine-induced killer cell therapy and high-dose vitamin C: a case report |
| title_sort | long term tumor suppression in cholangiocarcinoma using cytokine induced killer cell therapy and high dose vitamin c a case report |
| topic | cell therapy sodium-dependent vitamin c transporter-2 ascorbic acid cholangiocarcinoma case reports |
| url | http://www.kjco.org/upload/kjco-20-2-84.pdf |
| work_keys_str_mv | AT kangseokkim longtermtumorsuppressionincholangiocarcinomausingcytokineinducedkillercelltherapyandhighdosevitamincacasereport AT hyunhyewang longtermtumorsuppressionincholangiocarcinomausingcytokineinducedkillercelltherapyandhighdosevitamincacasereport AT jiewonlee longtermtumorsuppressionincholangiocarcinomausingcytokineinducedkillercelltherapyandhighdosevitamincacasereport AT changhwanyeom longtermtumorsuppressionincholangiocarcinomausingcytokineinducedkillercelltherapyandhighdosevitamincacasereport |