Low IL-6, IL-10, and TNF-α and High IL-13 Cytokine Levels Are Associated with Severe Hepatic Fibrosis in Schistosoma mansoni Chronically Exposed Individuals
Several studies have attributed the etiopathogenesis of chronic Schistosoma mansoni related hepatic fibrosis to unregulated immune responses against trapped parasite ova in the host. However, there is limited data on immune profiles associated with varying degrees of the disease in a population unde...
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| Format: | Article |
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Wiley
2018-01-01
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| Series: | Journal of Parasitology Research |
| Online Access: | http://dx.doi.org/10.1155/2018/9754060 |
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| author | Mable M. Mutengo Takafira Mduluza Paul Kelly James C. L. Mwansa Geoffrey Kwenda Patrick Musonda James Chipeta |
| author_facet | Mable M. Mutengo Takafira Mduluza Paul Kelly James C. L. Mwansa Geoffrey Kwenda Patrick Musonda James Chipeta |
| author_sort | Mable M. Mutengo |
| collection | DOAJ |
| description | Several studies have attributed the etiopathogenesis of chronic Schistosoma mansoni related hepatic fibrosis to unregulated immune responses against trapped parasite ova in the host. However, there is limited data on immune profiles associated with varying degrees of the disease in a population under chronic exposure to the parasite. We therefore investigated the role of selected T-helper (Th)1, Th2, and Th17 cytokines in relation to hepatic fibrosis severity among individuals resident in a hyper-Schistosoma mansoni endemic region of Western Zambia. Two hundred and forty-four S. mansoni infected individuals with and without fibrosis were analysed for cytokine profiles. Based on hepatic fibrosis stage as determined by ultrasound, participants were categorized into Group 0, Group I, Group II, and Group III. Cytokines were measured in S. mansoni egg stimulated whole blood culture supernatants using the BD Cytometric Bead Array kits. Compared to the nonfibrotic group, participants in the severe hepatic fibrotic group produced less interleukin- (IL-) 6, IL-10, and tumour necrosis factor-alpha (TNF-α). On the other hand, IL-13 was significantly elevated in this group compared to the nonfibrotic group (p<0.001). Our results suggest that low IL-6, IL-10, and TNF-α and high IL-13 levels may influence S. mansoni disease progression. |
| format | Article |
| id | doaj-art-d9b9123bb6754accb9a17e4d2620c55e |
| institution | Kabale University |
| issn | 2090-0023 2090-0031 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Parasitology Research |
| spelling | doaj-art-d9b9123bb6754accb9a17e4d2620c55e2025-02-03T01:31:07ZengWileyJournal of Parasitology Research2090-00232090-00312018-01-01201810.1155/2018/97540609754060Low IL-6, IL-10, and TNF-α and High IL-13 Cytokine Levels Are Associated with Severe Hepatic Fibrosis in Schistosoma mansoni Chronically Exposed IndividualsMable M. Mutengo0Takafira Mduluza1Paul Kelly2James C. L. Mwansa3Geoffrey Kwenda4Patrick Musonda5James Chipeta6Department of Pathology and Microbiology, University Teaching Hospital, Lusaka, ZambiaDepartment of Biochemistry, University of Zimbabwe, Mount Pleasant, Harare, ZimbabweDepartment of Internal Medicine, School of Medicine, University of Zambia, Lusaka, ZambiaDepartment of Pathology and Microbiology, University Teaching Hospital, Lusaka, ZambiaDepartment of Biomedical Sciences, School of Health Sciences, University of Zambia, Lusaka, ZambiaDepartment of Epidemiology and Biostatistics, School of Public Health, University of Zambia, Lusaka, ZambiaDepartment of Pediatrics and Child Health, School of Medicine, University of Zambia, Lusaka, ZambiaSeveral studies have attributed the etiopathogenesis of chronic Schistosoma mansoni related hepatic fibrosis to unregulated immune responses against trapped parasite ova in the host. However, there is limited data on immune profiles associated with varying degrees of the disease in a population under chronic exposure to the parasite. We therefore investigated the role of selected T-helper (Th)1, Th2, and Th17 cytokines in relation to hepatic fibrosis severity among individuals resident in a hyper-Schistosoma mansoni endemic region of Western Zambia. Two hundred and forty-four S. mansoni infected individuals with and without fibrosis were analysed for cytokine profiles. Based on hepatic fibrosis stage as determined by ultrasound, participants were categorized into Group 0, Group I, Group II, and Group III. Cytokines were measured in S. mansoni egg stimulated whole blood culture supernatants using the BD Cytometric Bead Array kits. Compared to the nonfibrotic group, participants in the severe hepatic fibrotic group produced less interleukin- (IL-) 6, IL-10, and tumour necrosis factor-alpha (TNF-α). On the other hand, IL-13 was significantly elevated in this group compared to the nonfibrotic group (p<0.001). Our results suggest that low IL-6, IL-10, and TNF-α and high IL-13 levels may influence S. mansoni disease progression.http://dx.doi.org/10.1155/2018/9754060 |
| spellingShingle | Mable M. Mutengo Takafira Mduluza Paul Kelly James C. L. Mwansa Geoffrey Kwenda Patrick Musonda James Chipeta Low IL-6, IL-10, and TNF-α and High IL-13 Cytokine Levels Are Associated with Severe Hepatic Fibrosis in Schistosoma mansoni Chronically Exposed Individuals Journal of Parasitology Research |
| title | Low IL-6, IL-10, and TNF-α and High IL-13 Cytokine Levels Are Associated with Severe Hepatic Fibrosis in Schistosoma mansoni Chronically Exposed Individuals |
| title_full | Low IL-6, IL-10, and TNF-α and High IL-13 Cytokine Levels Are Associated with Severe Hepatic Fibrosis in Schistosoma mansoni Chronically Exposed Individuals |
| title_fullStr | Low IL-6, IL-10, and TNF-α and High IL-13 Cytokine Levels Are Associated with Severe Hepatic Fibrosis in Schistosoma mansoni Chronically Exposed Individuals |
| title_full_unstemmed | Low IL-6, IL-10, and TNF-α and High IL-13 Cytokine Levels Are Associated with Severe Hepatic Fibrosis in Schistosoma mansoni Chronically Exposed Individuals |
| title_short | Low IL-6, IL-10, and TNF-α and High IL-13 Cytokine Levels Are Associated with Severe Hepatic Fibrosis in Schistosoma mansoni Chronically Exposed Individuals |
| title_sort | low il 6 il 10 and tnf α and high il 13 cytokine levels are associated with severe hepatic fibrosis in schistosoma mansoni chronically exposed individuals |
| url | http://dx.doi.org/10.1155/2018/9754060 |
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