Linear and non-linear association of chronic kidney disease with retina and choroid vessel density in diabetes: a prospective study
Purpose: To investigate the association of retinal and choroidal vessel density with renal function using optical coherence tomographic angiography (OCTA). Method: The present study prospectively recruited consecutive diabetes patients admitted to Beijing Liangxiang Hospital from October 2023 to Mar...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-06-01
|
| Series: | Photodiagnosis and Photodynamic Therapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1572100025001577 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849730066346409984 |
|---|---|
| author | Lijian Fang Ruiheng Zhang Suoqing Zhuang Lei Wang Qiuping Wang Yong Huang Mingli Wang Yu Feng Min Xiao Chunyuan Zhou Lili Wu Sihan Zhang Lili Xue Tong Tian Yuanyuan Li Bing Cao Huaiyu Hao |
| author_facet | Lijian Fang Ruiheng Zhang Suoqing Zhuang Lei Wang Qiuping Wang Yong Huang Mingli Wang Yu Feng Min Xiao Chunyuan Zhou Lili Wu Sihan Zhang Lili Xue Tong Tian Yuanyuan Li Bing Cao Huaiyu Hao |
| author_sort | Lijian Fang |
| collection | DOAJ |
| description | Purpose: To investigate the association of retinal and choroidal vessel density with renal function using optical coherence tomographic angiography (OCTA). Method: The present study prospectively recruited consecutive diabetes patients admitted to Beijing Liangxiang Hospital from October 2023 to March 2024. All participants underwent comprehensive ophthalmologic examinations and laboratory analysis at the first visit. Quantitative parameters of OCTA scans included retinal superficial vascular complex (SVC) and deep vascular complex (DVC) vessel densities, and choriocapillaris flow deficits (CCFD%). Results: A total of 85 patients were included in the present study. After adjusting for severity of diabetic retinopathy and other confounding factors, every 1 % increased SVC within in ETDRS grid was associated with reduced incidence of CKD (OR=0.86 95 %CI:[0.73–1.01]), decreased urine albumin-to-creatinine ratio (ACR, coefficient=-0.65, 95 %CI:[-1.22, -0.08]), and increased eGFR (coefficient=1.55, 95 %CI:[0.14, 2.96]). Every 1 % increased CCFD% was significantly associated with increased incidence of CKD (OR=1.72, 95 %CI:[1.14–2.58]) and decrease eGFR (coefficient=-6.47, 95 %CI:[-9.68, -3.26]). Non-linear regression revealed that SVC vessel density was associated with eGFR among patients with advanced retinal microvasculature damage. Conclusions: Retina and choroid blood flow were associated with the onset and severity of CKD. Decreased SVC and decreased CCFD% can be used for non-invasively screening CKD in diabetes patients. |
| format | Article |
| id | doaj-art-d9b8087f534147ac9b0072843f448dd3 |
| institution | DOAJ |
| issn | 1572-1000 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Photodiagnosis and Photodynamic Therapy |
| spelling | doaj-art-d9b8087f534147ac9b0072843f448dd32025-08-20T03:08:59ZengElsevierPhotodiagnosis and Photodynamic Therapy1572-10002025-06-015310462510.1016/j.pdpdt.2025.104625Linear and non-linear association of chronic kidney disease with retina and choroid vessel density in diabetes: a prospective studyLijian Fang0Ruiheng Zhang1Suoqing Zhuang2Lei Wang3Qiuping Wang4Yong Huang5Mingli Wang6Yu Feng7Min Xiao8Chunyuan Zhou9Lili Wu10Sihan Zhang11Lili Xue12Tong Tian13Yuanyuan Li14Bing Cao15Huaiyu Hao16Department of Ophthalmology, Liangxiang Hospital of Beijing Fangshan District, Capital Medical University, Beijing, China; Corresponding authors.Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, ChinaDepartment of Ophthalmology, Liangxiang Hospital of Beijing Fangshan District, Capital Medical University, Beijing, ChinaDepartment of Ophthalmology, Liangxiang Hospital of Beijing Fangshan District, Capital Medical University, Beijing, ChinaDepartment of Endocrinology, Liangxiang Hospital of Beijing Fangshan District, Capital Medical University, Beijing, ChinaDepartment of Ophthalmology, Liangxiang Hospital of Beijing Fangshan District, Capital Medical University, Beijing, ChinaDepartment of Ophthalmology, Liangxiang Hospital of Beijing Fangshan District, Capital Medical University, Beijing, ChinaDepartment of Ophthalmology, Liangxiang Hospital of Beijing Fangshan District, Capital Medical University, Beijing, ChinaDepartment of Ophthalmology, Liangxiang Hospital of Beijing Fangshan District, Capital Medical University, Beijing, ChinaDepartment of Ophthalmology, Liangxiang Hospital of Beijing Fangshan District, Capital Medical University, Beijing, ChinaDepartment of Ophthalmology, Liangxiang Hospital of Beijing Fangshan District, Capital Medical University, Beijing, ChinaDepartment of Ophthalmology, Liangxiang Hospital of Beijing Fangshan District, Capital Medical University, Beijing, ChinaDepartment of Ophthalmology, Liangxiang Hospital of Beijing Fangshan District, Capital Medical University, Beijing, ChinaDepartment of Ophthalmology, Liangxiang Hospital of Beijing Fangshan District, Capital Medical University, Beijing, ChinaDepartment of Ophthalmology, Liangxiang Hospital of Beijing Fangshan District, Capital Medical University, Beijing, ChinaDepartment of Ophthalmology, Liangxiang Hospital of Beijing Fangshan District, Capital Medical University, Beijing, ChinaDepartment of Neurosurgery, Liangxiang Hospital of Beijing Fangshan District, Capital Medical University, Beijing, China; Corresponding authors.Purpose: To investigate the association of retinal and choroidal vessel density with renal function using optical coherence tomographic angiography (OCTA). Method: The present study prospectively recruited consecutive diabetes patients admitted to Beijing Liangxiang Hospital from October 2023 to March 2024. All participants underwent comprehensive ophthalmologic examinations and laboratory analysis at the first visit. Quantitative parameters of OCTA scans included retinal superficial vascular complex (SVC) and deep vascular complex (DVC) vessel densities, and choriocapillaris flow deficits (CCFD%). Results: A total of 85 patients were included in the present study. After adjusting for severity of diabetic retinopathy and other confounding factors, every 1 % increased SVC within in ETDRS grid was associated with reduced incidence of CKD (OR=0.86 95 %CI:[0.73–1.01]), decreased urine albumin-to-creatinine ratio (ACR, coefficient=-0.65, 95 %CI:[-1.22, -0.08]), and increased eGFR (coefficient=1.55, 95 %CI:[0.14, 2.96]). Every 1 % increased CCFD% was significantly associated with increased incidence of CKD (OR=1.72, 95 %CI:[1.14–2.58]) and decrease eGFR (coefficient=-6.47, 95 %CI:[-9.68, -3.26]). Non-linear regression revealed that SVC vessel density was associated with eGFR among patients with advanced retinal microvasculature damage. Conclusions: Retina and choroid blood flow were associated with the onset and severity of CKD. Decreased SVC and decreased CCFD% can be used for non-invasively screening CKD in diabetes patients.http://www.sciencedirect.com/science/article/pii/S1572100025001577Chronic kidney diseaseDiabetesOptical coherence tomographic angiography |
| spellingShingle | Lijian Fang Ruiheng Zhang Suoqing Zhuang Lei Wang Qiuping Wang Yong Huang Mingli Wang Yu Feng Min Xiao Chunyuan Zhou Lili Wu Sihan Zhang Lili Xue Tong Tian Yuanyuan Li Bing Cao Huaiyu Hao Linear and non-linear association of chronic kidney disease with retina and choroid vessel density in diabetes: a prospective study Photodiagnosis and Photodynamic Therapy Chronic kidney disease Diabetes Optical coherence tomographic angiography |
| title | Linear and non-linear association of chronic kidney disease with retina and choroid vessel density in diabetes: a prospective study |
| title_full | Linear and non-linear association of chronic kidney disease with retina and choroid vessel density in diabetes: a prospective study |
| title_fullStr | Linear and non-linear association of chronic kidney disease with retina and choroid vessel density in diabetes: a prospective study |
| title_full_unstemmed | Linear and non-linear association of chronic kidney disease with retina and choroid vessel density in diabetes: a prospective study |
| title_short | Linear and non-linear association of chronic kidney disease with retina and choroid vessel density in diabetes: a prospective study |
| title_sort | linear and non linear association of chronic kidney disease with retina and choroid vessel density in diabetes a prospective study |
| topic | Chronic kidney disease Diabetes Optical coherence tomographic angiography |
| url | http://www.sciencedirect.com/science/article/pii/S1572100025001577 |
| work_keys_str_mv | AT lijianfang linearandnonlinearassociationofchronickidneydiseasewithretinaandchoroidvesseldensityindiabetesaprospectivestudy AT ruihengzhang linearandnonlinearassociationofchronickidneydiseasewithretinaandchoroidvesseldensityindiabetesaprospectivestudy AT suoqingzhuang linearandnonlinearassociationofchronickidneydiseasewithretinaandchoroidvesseldensityindiabetesaprospectivestudy AT leiwang linearandnonlinearassociationofchronickidneydiseasewithretinaandchoroidvesseldensityindiabetesaprospectivestudy AT qiupingwang linearandnonlinearassociationofchronickidneydiseasewithretinaandchoroidvesseldensityindiabetesaprospectivestudy AT yonghuang linearandnonlinearassociationofchronickidneydiseasewithretinaandchoroidvesseldensityindiabetesaprospectivestudy AT mingliwang linearandnonlinearassociationofchronickidneydiseasewithretinaandchoroidvesseldensityindiabetesaprospectivestudy AT yufeng linearandnonlinearassociationofchronickidneydiseasewithretinaandchoroidvesseldensityindiabetesaprospectivestudy AT minxiao linearandnonlinearassociationofchronickidneydiseasewithretinaandchoroidvesseldensityindiabetesaprospectivestudy AT chunyuanzhou linearandnonlinearassociationofchronickidneydiseasewithretinaandchoroidvesseldensityindiabetesaprospectivestudy AT liliwu linearandnonlinearassociationofchronickidneydiseasewithretinaandchoroidvesseldensityindiabetesaprospectivestudy AT sihanzhang linearandnonlinearassociationofchronickidneydiseasewithretinaandchoroidvesseldensityindiabetesaprospectivestudy AT lilixue linearandnonlinearassociationofchronickidneydiseasewithretinaandchoroidvesseldensityindiabetesaprospectivestudy AT tongtian linearandnonlinearassociationofchronickidneydiseasewithretinaandchoroidvesseldensityindiabetesaprospectivestudy AT yuanyuanli linearandnonlinearassociationofchronickidneydiseasewithretinaandchoroidvesseldensityindiabetesaprospectivestudy AT bingcao linearandnonlinearassociationofchronickidneydiseasewithretinaandchoroidvesseldensityindiabetesaprospectivestudy AT huaiyuhao linearandnonlinearassociationofchronickidneydiseasewithretinaandchoroidvesseldensityindiabetesaprospectivestudy |