Tumor-infiltrating CD4+ CD25+ FOXP3+ Treg is associated with plasma EBV DNA and disease progression in nasopharyngeal carcinoma

Tumor-infiltrating CD4+ CD25+ FOXP3+ Treg is associated with plasma EBV DNA and disease progression in nasopharyngeal carcinoma

Abstract Background Regulatory T cells (Tregs) play a significant role in immune evasion within the tumor microenvironment (TME). Nasopharyngeal carcinoma (NPC) is strongly associated with Epstein-Barr virus (EBV) infection. Previous studies have shown that EBV can suppress immune activity. The rela...

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Bibliographic Details
Main Authors: Enzi Feng, Yaoyu Yang, Jie Yang, Rongyi Hu, Ling Tian, Xinyu Yang, Meng Yang, Qianqian Qu, Yanxin Ren, Xiaojiang Li
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Infectious Agents and Cancer
Subjects:
Nasopharyngeal carcinoma
Regulatory T cell
Tumor-Infiltrating lymphocyte
Online Access:https://doi.org/10.1186/s13027-025-00660-4
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