Influence of the Cholinergic System on the Immune Response of Teleost Fishes: Potential Model in Biomedical Research
Fishes are the phylogenetically oldest vertebrate group, which includes more than one-half of the vertebrates on the planet; additionally, many species have ecological and economic importance. Fish are the first evolved group of organisms with adaptive immune mechanisms; consequently, they are an im...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2013/536534 |
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| author | G. A. Toledo-Ibarra A. E. Rojas-Mayorquín M. I. Girón-Pérez |
| author_facet | G. A. Toledo-Ibarra A. E. Rojas-Mayorquín M. I. Girón-Pérez |
| author_sort | G. A. Toledo-Ibarra |
| collection | DOAJ |
| description | Fishes are the phylogenetically oldest vertebrate group, which includes more than one-half of the vertebrates on the planet; additionally, many species have ecological and economic importance. Fish are the first evolved group of organisms with adaptive immune mechanisms; consequently, they are an important link in the evolution of the immune system, thus a potential model for understanding the mechanisms of immunoregulation. Currently, the influence of the neurotransmitter acetylcholine (ACh) on the cells of the immune system is widely studied in mammalian models, which have provided evidence on ACh production by immune cells (the noncholinergic neuronal system); however, these neuroimmunomodulation mechanisms in fish and lower vertebrates are poorly studied. Therefore, the objective of this review paper was to analyze the influence of the cholinergic system on the immune response of teleost fish, which could provide information concerning the possibility of bidirectional communication between the nervous and immune systems in these organisms and provide data for a better understanding of basic issues in neuroimmunology in lower vertebrates, such as bony fishes. Thus, the use of fish as a model in biomedical research may contribute to a better understanding of human diseases and diseases in other animals. |
| format | Article |
| id | doaj-art-d9b206f27cfa4c77a50968efcadc2bd9 |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-d9b206f27cfa4c77a50968efcadc2bd92025-08-20T03:24:22ZengWileyClinical and Developmental Immunology1740-25221740-25302013-01-01201310.1155/2013/536534536534Influence of the Cholinergic System on the Immune Response of Teleost Fishes: Potential Model in Biomedical ResearchG. A. Toledo-Ibarra0A. E. Rojas-Mayorquín1M. I. Girón-Pérez2Universidad Autónoma de Nayarit (UAN), Secretaría de Investigación y Posgrado, Laboratorio de Inmunotoxicología, Boulevard Tepic-Xalisco s/n, Cd de la Cultura Amado Nervo, 63190 Tepic, Nayarit, MexicoDepartamento de Ciencias Ambientales, Instituto de Neurociencias, Centro Universitario de Ciencias Biológicas y Agropecuarias (CUCBA), Universidad de Guadalajara (UdeG), Francisco de Quevedo 180, Col. Arcos Vallarta, 45100 Guadalajara, Jal, MexicoUniversidad Autónoma de Nayarit (UAN), Secretaría de Investigación y Posgrado, Laboratorio de Inmunotoxicología, Boulevard Tepic-Xalisco s/n, Cd de la Cultura Amado Nervo, 63190 Tepic, Nayarit, MexicoFishes are the phylogenetically oldest vertebrate group, which includes more than one-half of the vertebrates on the planet; additionally, many species have ecological and economic importance. Fish are the first evolved group of organisms with adaptive immune mechanisms; consequently, they are an important link in the evolution of the immune system, thus a potential model for understanding the mechanisms of immunoregulation. Currently, the influence of the neurotransmitter acetylcholine (ACh) on the cells of the immune system is widely studied in mammalian models, which have provided evidence on ACh production by immune cells (the noncholinergic neuronal system); however, these neuroimmunomodulation mechanisms in fish and lower vertebrates are poorly studied. Therefore, the objective of this review paper was to analyze the influence of the cholinergic system on the immune response of teleost fish, which could provide information concerning the possibility of bidirectional communication between the nervous and immune systems in these organisms and provide data for a better understanding of basic issues in neuroimmunology in lower vertebrates, such as bony fishes. Thus, the use of fish as a model in biomedical research may contribute to a better understanding of human diseases and diseases in other animals.http://dx.doi.org/10.1155/2013/536534 |
| spellingShingle | G. A. Toledo-Ibarra A. E. Rojas-Mayorquín M. I. Girón-Pérez Influence of the Cholinergic System on the Immune Response of Teleost Fishes: Potential Model in Biomedical Research Clinical and Developmental Immunology |
| title | Influence of the Cholinergic System on the Immune Response of Teleost Fishes: Potential Model in Biomedical Research |
| title_full | Influence of the Cholinergic System on the Immune Response of Teleost Fishes: Potential Model in Biomedical Research |
| title_fullStr | Influence of the Cholinergic System on the Immune Response of Teleost Fishes: Potential Model in Biomedical Research |
| title_full_unstemmed | Influence of the Cholinergic System on the Immune Response of Teleost Fishes: Potential Model in Biomedical Research |
| title_short | Influence of the Cholinergic System on the Immune Response of Teleost Fishes: Potential Model in Biomedical Research |
| title_sort | influence of the cholinergic system on the immune response of teleost fishes potential model in biomedical research |
| url | http://dx.doi.org/10.1155/2013/536534 |
| work_keys_str_mv | AT gatoledoibarra influenceofthecholinergicsystemontheimmuneresponseofteleostfishespotentialmodelinbiomedicalresearch AT aerojasmayorquin influenceofthecholinergicsystemontheimmuneresponseofteleostfishespotentialmodelinbiomedicalresearch AT migironperez influenceofthecholinergicsystemontheimmuneresponseofteleostfishespotentialmodelinbiomedicalresearch |