Clinical Comparison between HD-tDCS and tDCS for Improving Upper Limb Motor Function: A Randomized, Double-Blinded, Sham-Controlled Trial
Background. Stroke is a common and frequently occurring disease among middle-aged and elderly people, with approximately 55%−75% of patients remaining with upper limb dysfunction. How to promote the recovery of motor function at an early stage is crucial to the life of the patient. Objectives. This...
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| Format: | Article |
| Language: | English |
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Wiley
2024-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2024/2512796 |
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| author | Yaqin Zeng Ruidong Cheng Li Zhang Shan Fang Shaomin Zhang Minmin Wang Qian Lv Yunlan Dai Xinyi Gong Feng Liang |
| author_facet | Yaqin Zeng Ruidong Cheng Li Zhang Shan Fang Shaomin Zhang Minmin Wang Qian Lv Yunlan Dai Xinyi Gong Feng Liang |
| author_sort | Yaqin Zeng |
| collection | DOAJ |
| description | Background. Stroke is a common and frequently occurring disease among middle-aged and elderly people, with approximately 55%−75% of patients remaining with upper limb dysfunction. How to promote the recovery of motor function at an early stage is crucial to the life of the patient. Objectives. This study aimed to investigate whether high-definition transcranial direct current stimulation (HD-tDCS) of the primary motor cortex (M1) functional area in poststroke patients in the subacute phase is more effective in improving upper limb function than conventional tDCS. Methods. This randomized, sham-controlled clinical trial included 69 patients with subcortical stroke. They were randomly divided into the HD-tDCS, anodal tDCS (a-tDCS), and sham groups. Each group received 20 sessions of stimulation. The patients were assessed using the Action Research Arm Test, Fugl–Meyer score for upper extremities, Motor Function Assessment Scale, and modified Barthel index (MBI) pretreatment and posttreatment. Results. The intragroup comparison scores improved after 4 weeks of treatment. The HD-tDCS group showed a slightly greater, but nonsignificant improvement as compared to a-tDCS group in terms of mean change observed in function of trained items. The MBI score of the HD-tDCS group was maintained up to 8 weeks of follow-up and was higher than that in the a-tDCS group. Conclusion. Both HD-tDCS and a-tDCS can improve upper limb motor function and daily activities of poststroke patients in the subacute stage. This trial is registered with ChiCTR2000031314. |
| format | Article |
| id | doaj-art-d9af73e6b124418088983116b7c54255 |
| institution | Kabale University |
| issn | 1687-5443 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-d9af73e6b124418088983116b7c542552025-02-03T05:54:34ZengWileyNeural Plasticity1687-54432024-01-01202410.1155/2024/2512796Clinical Comparison between HD-tDCS and tDCS for Improving Upper Limb Motor Function: A Randomized, Double-Blinded, Sham-Controlled TrialYaqin Zeng0Ruidong Cheng1Li Zhang2Shan Fang3Shaomin Zhang4Minmin Wang5Qian Lv6Yunlan Dai7Xinyi Gong8Feng Liang9Center for Rehabilitation MedicineCenter for Rehabilitation MedicineCenter for Rehabilitation MedicineCenter for Rehabilitation MedicineQiushi Academy for Advanced StudiesQiushi Academy for Advanced StudiesCenter for Rehabilitation MedicineCenter for Rehabilitation MedicineCenter for Rehabilitation MedicineCenter for Rehabilitation MedicineBackground. Stroke is a common and frequently occurring disease among middle-aged and elderly people, with approximately 55%−75% of patients remaining with upper limb dysfunction. How to promote the recovery of motor function at an early stage is crucial to the life of the patient. Objectives. This study aimed to investigate whether high-definition transcranial direct current stimulation (HD-tDCS) of the primary motor cortex (M1) functional area in poststroke patients in the subacute phase is more effective in improving upper limb function than conventional tDCS. Methods. This randomized, sham-controlled clinical trial included 69 patients with subcortical stroke. They were randomly divided into the HD-tDCS, anodal tDCS (a-tDCS), and sham groups. Each group received 20 sessions of stimulation. The patients were assessed using the Action Research Arm Test, Fugl–Meyer score for upper extremities, Motor Function Assessment Scale, and modified Barthel index (MBI) pretreatment and posttreatment. Results. The intragroup comparison scores improved after 4 weeks of treatment. The HD-tDCS group showed a slightly greater, but nonsignificant improvement as compared to a-tDCS group in terms of mean change observed in function of trained items. The MBI score of the HD-tDCS group was maintained up to 8 weeks of follow-up and was higher than that in the a-tDCS group. Conclusion. Both HD-tDCS and a-tDCS can improve upper limb motor function and daily activities of poststroke patients in the subacute stage. This trial is registered with ChiCTR2000031314.http://dx.doi.org/10.1155/2024/2512796 |
| spellingShingle | Yaqin Zeng Ruidong Cheng Li Zhang Shan Fang Shaomin Zhang Minmin Wang Qian Lv Yunlan Dai Xinyi Gong Feng Liang Clinical Comparison between HD-tDCS and tDCS for Improving Upper Limb Motor Function: A Randomized, Double-Blinded, Sham-Controlled Trial Neural Plasticity |
| title | Clinical Comparison between HD-tDCS and tDCS for Improving Upper Limb Motor Function: A Randomized, Double-Blinded, Sham-Controlled Trial |
| title_full | Clinical Comparison between HD-tDCS and tDCS for Improving Upper Limb Motor Function: A Randomized, Double-Blinded, Sham-Controlled Trial |
| title_fullStr | Clinical Comparison between HD-tDCS and tDCS for Improving Upper Limb Motor Function: A Randomized, Double-Blinded, Sham-Controlled Trial |
| title_full_unstemmed | Clinical Comparison between HD-tDCS and tDCS for Improving Upper Limb Motor Function: A Randomized, Double-Blinded, Sham-Controlled Trial |
| title_short | Clinical Comparison between HD-tDCS and tDCS for Improving Upper Limb Motor Function: A Randomized, Double-Blinded, Sham-Controlled Trial |
| title_sort | clinical comparison between hd tdcs and tdcs for improving upper limb motor function a randomized double blinded sham controlled trial |
| url | http://dx.doi.org/10.1155/2024/2512796 |
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