Safety and efficacy of MCO-010 optogenetic therapy in patients with Stargardt disease in USA (STARLIGHT): an open-label multi-center Ph2 trialResearch in context

Safety and efficacy of MCO-010 optogenetic therapy in patients with Stargardt disease in USA (STARLIGHT): an open-label multi-center Ph2 trialResearch in context

Summary: Background: Stargardt disease (SD) is an inherited degenerative retinal disease affecting rod and cone photoreceptors and retinal pigment epithelial (RPE) cells, leading to severe and irreversible vision loss. Optogenetics is a promising approach to restoring vision by photosensitizing spa...

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Main Authors: Byron L. Lam, Vitaliy Zak, Victor H. Gonzalez, Ninel Z. Gregori, Sai H. Chavala, Subrata Batabyal, Michael Carlson, Sanghoon Kim, Ananta Ayyagari, Jean Chang, Hayley Lane, Nozhat Choudry, John Koester, Mark Von Tress, Jody Piltz-Seymour, Najam A. Sharif, Stephen H. Tsang, Vinit B. Mahajan, David S. Boyer, Allen C. Ho, Samuel B. Barone, Samarendra K. Mohanty
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:EClinicalMedicine
Subjects:
Retinal degenerative disease
Stargardt macular degeneration
Optogenetics
Multi-characteristic opsin
Vision restoration
Online Access:http://www.sciencedirect.com/science/article/pii/S2589537025003621
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