A Sensitive UV Spectrophotometric Method for the Determination of Gabapentin
An accurate and validated spectrophotometric method was developed for the determination of gabapentin. This is simple, sensitive and low cost UV spectrophotometric method. The method is based on the direct measurement of the native absorbance of the drug. The detection was done at 210 nm. The method...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley
2009-01-01
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| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2009/451967 |
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| _version_ | 1849472864008273920 |
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| author | R. Singh Gujral S. Manirul Haque P. Shanker |
| author_facet | R. Singh Gujral S. Manirul Haque P. Shanker |
| author_sort | R. Singh Gujral |
| collection | DOAJ |
| description | An accurate and validated spectrophotometric method was developed for the determination of gabapentin. This is simple, sensitive and low cost UV spectrophotometric method. The method is based on the direct measurement of the native absorbance of the drug. The detection was done at 210 nm. The method was linear in the range of 0.25 - 3.5 µ g/mL with correlation coefficient of 0.9999. It is validated according to the ICH guidelines with respect to linearity, selectivity, accuracy and precision, limit of quantitation and limit of detection. The method has been applied to assess gabapentin in pharmaceutical formulations with good accuracy and precision and relatively free of interference from coexisting substances. |
| format | Article |
| id | doaj-art-d9a1dd3d25cb4241bdacf7ecd608bf68 |
| institution | Kabale University |
| issn | 0973-4945 2090-9810 |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | E-Journal of Chemistry |
| spelling | doaj-art-d9a1dd3d25cb4241bdacf7ecd608bf682025-08-20T03:24:22ZengWileyE-Journal of Chemistry0973-49452090-98102009-01-016S1S163S17010.1155/2009/451967A Sensitive UV Spectrophotometric Method for the Determination of GabapentinR. Singh Gujral0S. Manirul Haque1P. Shanker2Vardhman Chemtech Ltd, Nimbua, Dera Bassi, Mohali (Punjab), IndiaVardhman Chemtech Ltd, Nimbua, Dera Bassi, Mohali (Punjab), IndiaVardhman Chemtech Ltd, Nimbua, Dera Bassi, Mohali (Punjab), IndiaAn accurate and validated spectrophotometric method was developed for the determination of gabapentin. This is simple, sensitive and low cost UV spectrophotometric method. The method is based on the direct measurement of the native absorbance of the drug. The detection was done at 210 nm. The method was linear in the range of 0.25 - 3.5 µ g/mL with correlation coefficient of 0.9999. It is validated according to the ICH guidelines with respect to linearity, selectivity, accuracy and precision, limit of quantitation and limit of detection. The method has been applied to assess gabapentin in pharmaceutical formulations with good accuracy and precision and relatively free of interference from coexisting substances.http://dx.doi.org/10.1155/2009/451967 |
| spellingShingle | R. Singh Gujral S. Manirul Haque P. Shanker A Sensitive UV Spectrophotometric Method for the Determination of Gabapentin E-Journal of Chemistry |
| title | A Sensitive UV Spectrophotometric Method for the Determination of Gabapentin |
| title_full | A Sensitive UV Spectrophotometric Method for the Determination of Gabapentin |
| title_fullStr | A Sensitive UV Spectrophotometric Method for the Determination of Gabapentin |
| title_full_unstemmed | A Sensitive UV Spectrophotometric Method for the Determination of Gabapentin |
| title_short | A Sensitive UV Spectrophotometric Method for the Determination of Gabapentin |
| title_sort | sensitive uv spectrophotometric method for the determination of gabapentin |
| url | http://dx.doi.org/10.1155/2009/451967 |
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