Prevalence and assessment of the impact of iron-deficiency anemia in beta-thalassemia trait subjects: A study from a tertiary care center of Western India
INTRODUCTION: Beta-thalassemia trait (BTT) and iron-deficiency anemia (IDA) are the most common causes of microcytic hypochromic anemia (MHA). Concomitant presence of both BTT and IDA can cause a more severe form of anemia that may increase morbidity and mortality. Therefore, the present study was c...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-07-01
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| Series: | Asian Journal of Transfusion Science |
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| Online Access: | https://journals.lww.com/10.4103/ajts.ajts_111_22 |
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| author | Virender Singh Ajay Kumar Baranwal Amit Kumar Biswas Ratish Chandra Mishra Ishawar Singh |
| author_facet | Virender Singh Ajay Kumar Baranwal Amit Kumar Biswas Ratish Chandra Mishra Ishawar Singh |
| author_sort | Virender Singh |
| collection | DOAJ |
| description | INTRODUCTION:
Beta-thalassemia trait (BTT) and iron-deficiency anemia (IDA) are the most common causes of microcytic hypochromic anemia (MHA). Concomitant presence of both BTT and IDA can cause a more severe form of anemia that may increase morbidity and mortality. Therefore, the present study was conducted to check the prevalence and assess the impact of IDA on various hematological parameters in BTT subjects.
SUBJECTS AND METHODS:
The present study was conducted at the department of immunohematology and blood transfusion after taking ethical clearance and written informed consent from all the participants. One hundred and sixty-eight known cases of BTT were included in this study. Out of these, 88 were females and the remaining 80 were males with ages ranging from 9 to 65 years. Blood samples collected in ethylenediaminetetraacetic acid and sterile vacutainers were assessed for complete blood count, serum iron, total iron-binding capacity (TIBC), and ferritin. All the data were analyzed using IBM SPSS Statistics software version 28.0.1.1 (15).
RESULTS:
The majority of the patients had MHA on peripheral blood smears. Thirty-nine (23.21%) out of 168 BTT subjects were found to have IDA. Hemoglobin, mean corpuscular volume, mean cell hemoglobin, and mean cell hemoglobin concentration levels were significantly reduced in patients of Group I (BTT with IDA) when compared to Group II (BTT without IDA). The mean (± standard deviation) value of serum iron, total TIBC, and ferritin showed significant differences between the two groups.
DISCUSSIONS AND CONCLUSION:
High prevalence of IDA in patients of BTT in the current study suggests that there is a need for careful evaluation in the differentiation and diagnosis of BTT and IDA, especially in females, as IDA is more common in females. Moreover, IDA has a significant impact on various hematological parameters in BTT subjects. |
| format | Article |
| id | doaj-art-d9a07e5dbe1e4ee1b3ba977413a30065 |
| institution | Kabale University |
| issn | 0973-6247 1998-3565 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Asian Journal of Transfusion Science |
| spelling | doaj-art-d9a07e5dbe1e4ee1b3ba977413a300652025-08-20T03:44:28ZengWolters Kluwer Medknow PublicationsAsian Journal of Transfusion Science0973-62471998-35652025-07-01191485210.4103/ajts.ajts_111_22Prevalence and assessment of the impact of iron-deficiency anemia in beta-thalassemia trait subjects: A study from a tertiary care center of Western IndiaVirender SinghAjay Kumar BaranwalAmit Kumar BiswasRatish Chandra MishraIshawar SinghINTRODUCTION: Beta-thalassemia trait (BTT) and iron-deficiency anemia (IDA) are the most common causes of microcytic hypochromic anemia (MHA). Concomitant presence of both BTT and IDA can cause a more severe form of anemia that may increase morbidity and mortality. Therefore, the present study was conducted to check the prevalence and assess the impact of IDA on various hematological parameters in BTT subjects. SUBJECTS AND METHODS: The present study was conducted at the department of immunohematology and blood transfusion after taking ethical clearance and written informed consent from all the participants. One hundred and sixty-eight known cases of BTT were included in this study. Out of these, 88 were females and the remaining 80 were males with ages ranging from 9 to 65 years. Blood samples collected in ethylenediaminetetraacetic acid and sterile vacutainers were assessed for complete blood count, serum iron, total iron-binding capacity (TIBC), and ferritin. All the data were analyzed using IBM SPSS Statistics software version 28.0.1.1 (15). RESULTS: The majority of the patients had MHA on peripheral blood smears. Thirty-nine (23.21%) out of 168 BTT subjects were found to have IDA. Hemoglobin, mean corpuscular volume, mean cell hemoglobin, and mean cell hemoglobin concentration levels were significantly reduced in patients of Group I (BTT with IDA) when compared to Group II (BTT without IDA). The mean (± standard deviation) value of serum iron, total TIBC, and ferritin showed significant differences between the two groups. DISCUSSIONS AND CONCLUSION: High prevalence of IDA in patients of BTT in the current study suggests that there is a need for careful evaluation in the differentiation and diagnosis of BTT and IDA, especially in females, as IDA is more common in females. Moreover, IDA has a significant impact on various hematological parameters in BTT subjects.https://journals.lww.com/10.4103/ajts.ajts_111_22anemiabeta-thalassemiaferritiniron deficiencytotal iron-binding capacity |
| spellingShingle | Virender Singh Ajay Kumar Baranwal Amit Kumar Biswas Ratish Chandra Mishra Ishawar Singh Prevalence and assessment of the impact of iron-deficiency anemia in beta-thalassemia trait subjects: A study from a tertiary care center of Western India Asian Journal of Transfusion Science anemia beta-thalassemia ferritin iron deficiency total iron-binding capacity |
| title | Prevalence and assessment of the impact of iron-deficiency anemia in beta-thalassemia trait subjects: A study from a tertiary care center of Western India |
| title_full | Prevalence and assessment of the impact of iron-deficiency anemia in beta-thalassemia trait subjects: A study from a tertiary care center of Western India |
| title_fullStr | Prevalence and assessment of the impact of iron-deficiency anemia in beta-thalassemia trait subjects: A study from a tertiary care center of Western India |
| title_full_unstemmed | Prevalence and assessment of the impact of iron-deficiency anemia in beta-thalassemia trait subjects: A study from a tertiary care center of Western India |
| title_short | Prevalence and assessment of the impact of iron-deficiency anemia in beta-thalassemia trait subjects: A study from a tertiary care center of Western India |
| title_sort | prevalence and assessment of the impact of iron deficiency anemia in beta thalassemia trait subjects a study from a tertiary care center of western india |
| topic | anemia beta-thalassemia ferritin iron deficiency total iron-binding capacity |
| url | https://journals.lww.com/10.4103/ajts.ajts_111_22 |
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