Vaccination-induced neutralizing antibodies in immunocompetent hosts correlate with protection against rickettsiae

Vaccination-induced neutralizing antibodies in immunocompetent hosts correlate with protection against rickettsiae

Abstract We previously demonstrated that a single-dose immunization with a live-attenuated Rickettsia parkeri mutant 3A2 confers complete protection against murine spotted fever rickettsioses. In this study, we investigated whether vaccination-elicited serum antibodies serve as immune correlates of...

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Main Authors: Loka Reddy Velatooru, Jessica Plante, Chen Yi Chu, Garrett Cutchin, Bing Zhu, Nicole Burkhardt, Carsen Roach, Yingzi Cong, Shahid Karim, Yong-Fang Kuo, David H. Walker, Ulrike Munderloh, Rong Fang
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:npj Vaccines
Online Access:https://doi.org/10.1038/s41541-025-01228-4
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