Cyclin dependent kinase 9 inhibitor induces transcription-replication conflicts and DNA damage accumulation in breast cancer

Cyclin dependent kinase 9 inhibitor induces transcription-replication conflicts and DNA damage accumulation in breast cancer

Abstract Background Cyclin-dependent kinase 9 (CDK9) is a crucial regulator of transcriptional progression of RNA polymerase-II (RNAP2). RNA polymerases trapped in DNA can be a source of transcription-replication conflict (T-R conflict), which is a common source of replication stress. AZD4573, a hig...

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Bibliographic Details
Main Authors: Minyoung Lee, Kyung-Hun Lee, Ahrum Min, So Hyeon Kim, Sujin Ham, Hae Min Hwang, Youlim Noh, Yu-Jin Kim, Dae-Won Lee, Jiwon Koh, Seock-Ah Im
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Cancer Cell International
Subjects:
Breast cancer
Cyclin dependent kinase 9
DNA damage
Transcription-replication conflict
Online Access:https://doi.org/10.1186/s12935-025-03897-6
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