OPEN DUCTUS ARTERIOSUS IN PREMATURE INFANTS WITH EXTREMELY LOW AND VERY LOW BODY WEIGHT
The aim of the research – to identify significant factors affecting the postnatal functioning of PDA in premature infants with extremely low and very low body weight and to evaluate them from a manageability perspective. Materials and methods. In a continuous prospective study, 98 premature infants...
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| Language: | Russian |
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The Publishing House Medicine and Enlightenment
2025-02-01
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| Series: | Мать и дитя в Кузбассе |
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| Online Access: | https://mednauki.ru/index.php/MD/article/view/1204 |
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| author | Людмила Николаевна Игишева Жанна Анатольевна Звягина Елена Глебовна Цой Андрей Владимирович Шабалдин Тамара Михайловна Вакулова |
| author_facet | Людмила Николаевна Игишева Жанна Анатольевна Звягина Елена Глебовна Цой Андрей Владимирович Шабалдин Тамара Михайловна Вакулова |
| author_sort | Людмила Николаевна Игишева |
| collection | DOAJ |
| description | The aim of the research – to identify significant factors affecting the postnatal functioning of PDA in premature infants with extremely low and very low body weight and to evaluate them from a manageability perspective.
Materials and methods. In a continuous prospective study, 98 premature infants in the first 72 hours of life were divided into 2 groups according to the results of an echocardiological examination (67 children with PDA, 31 children without DA At the age of 1 month of life, 90 newborns were monitored, 48 children had open AP, and 42 children had no AP. Hemodynamic and laboratory data (NT- proBNP) were studied.
Results. At 72 hours of life, premature infants with PDA and without it had no hemodynamic differences. At 1 month of life, the features of intracardiac hemodynamics were revealed in the PDA group: myocardial hypertrophy (thickness interventricular septum 3.26 mm, p = 0.039), dilation of the left ventricle (end systolic volume 1.97 ml, p = 0.04), tricuspid regurgitation (21.29 mmHg, p = 0.021). The level of NT – proBNP in the early neonatal period and at 1 month of life did not exceed the accepted reference values. At 1 month, a significant set of factors was determined: the duration of the anhydrous period, the Apgar score at 5 minutes, the syndrome of general depression of the central nervous system at 2 weeks of life, respiratory acidosis at birth, hemodynamic parameters at 72 hours of life (large final diastolic size and open oval window), changes in the pulmonary interstitium at 2 weeks of life, based on which, using multiple logistic regression, an algorithm for the probability of PDA is constructed. Controlled and controllable factors of the state of the AP can be recognized as the parameters of the acid-base state.
Conclusion. Signs of myocardial remodeling were diagnosed as a result of adaptive processes in the body of premature infants. Assessment and correction of the acid-base state parameters (BE, pO2 and pCO2) in the first 72 hours of postnatal life will allow monitoring of PDA. |
| format | Article |
| id | doaj-art-d98b4b288fff4e81a2f033018e42ccb4 |
| institution | OA Journals |
| issn | 1991-010X 2542-0968 |
| language | Russian |
| publishDate | 2025-02-01 |
| publisher | The Publishing House Medicine and Enlightenment |
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| series | Мать и дитя в Кузбассе |
| spelling | doaj-art-d98b4b288fff4e81a2f033018e42ccb42025-08-20T02:19:45ZrusThe Publishing House Medicine and EnlightenmentМать и дитя в Кузбассе1991-010X2542-09682025-02-0126159651023OPEN DUCTUS ARTERIOSUS IN PREMATURE INFANTS WITH EXTREMELY LOW AND VERY LOW BODY WEIGHTЛюдмила Николаевна Игишева0Жанна Анатольевна Звягина1Елена Глебовна Цой2Андрей Владимирович Шабалдин3Тамара Михайловна Вакулова4ФГБОУ ВО КемГМУ Минздрава России; ФГБНУ НИИ КПССЗ, г. КемеровоГАУЗ КОДКБ им. Ю.А. Атаманова, г. КемеровоФГБОУ ВО КемГМУ Минздрава России, г. КемеровоФГБОУ ВО КемГМУ Минздрава России, г. КемеровоФГБОУ ВО КемГМУ Минздрава России, г. КемеровоThe aim of the research – to identify significant factors affecting the postnatal functioning of PDA in premature infants with extremely low and very low body weight and to evaluate them from a manageability perspective. Materials and methods. In a continuous prospective study, 98 premature infants in the first 72 hours of life were divided into 2 groups according to the results of an echocardiological examination (67 children with PDA, 31 children without DA At the age of 1 month of life, 90 newborns were monitored, 48 children had open AP, and 42 children had no AP. Hemodynamic and laboratory data (NT- proBNP) were studied. Results. At 72 hours of life, premature infants with PDA and without it had no hemodynamic differences. At 1 month of life, the features of intracardiac hemodynamics were revealed in the PDA group: myocardial hypertrophy (thickness interventricular septum 3.26 mm, p = 0.039), dilation of the left ventricle (end systolic volume 1.97 ml, p = 0.04), tricuspid regurgitation (21.29 mmHg, p = 0.021). The level of NT – proBNP in the early neonatal period and at 1 month of life did not exceed the accepted reference values. At 1 month, a significant set of factors was determined: the duration of the anhydrous period, the Apgar score at 5 minutes, the syndrome of general depression of the central nervous system at 2 weeks of life, respiratory acidosis at birth, hemodynamic parameters at 72 hours of life (large final diastolic size and open oval window), changes in the pulmonary interstitium at 2 weeks of life, based on which, using multiple logistic regression, an algorithm for the probability of PDA is constructed. Controlled and controllable factors of the state of the AP can be recognized as the parameters of the acid-base state. Conclusion. Signs of myocardial remodeling were diagnosed as a result of adaptive processes in the body of premature infants. Assessment and correction of the acid-base state parameters (BE, pO2 and pCO2) in the first 72 hours of postnatal life will allow monitoring of PDA.https://mednauki.ru/index.php/MD/article/view/1204недоношенные детиэкстремально низкая масса телаочень низкая масса телаоткрытый артериальный проток |
| spellingShingle | Людмила Николаевна Игишева Жанна Анатольевна Звягина Елена Глебовна Цой Андрей Владимирович Шабалдин Тамара Михайловна Вакулова OPEN DUCTUS ARTERIOSUS IN PREMATURE INFANTS WITH EXTREMELY LOW AND VERY LOW BODY WEIGHT Мать и дитя в Кузбассе недоношенные дети экстремально низкая масса тела очень низкая масса тела открытый артериальный проток |
| title | OPEN DUCTUS ARTERIOSUS IN PREMATURE INFANTS WITH EXTREMELY LOW AND VERY LOW BODY WEIGHT |
| title_full | OPEN DUCTUS ARTERIOSUS IN PREMATURE INFANTS WITH EXTREMELY LOW AND VERY LOW BODY WEIGHT |
| title_fullStr | OPEN DUCTUS ARTERIOSUS IN PREMATURE INFANTS WITH EXTREMELY LOW AND VERY LOW BODY WEIGHT |
| title_full_unstemmed | OPEN DUCTUS ARTERIOSUS IN PREMATURE INFANTS WITH EXTREMELY LOW AND VERY LOW BODY WEIGHT |
| title_short | OPEN DUCTUS ARTERIOSUS IN PREMATURE INFANTS WITH EXTREMELY LOW AND VERY LOW BODY WEIGHT |
| title_sort | open ductus arteriosus in premature infants with extremely low and very low body weight |
| topic | недоношенные дети экстремально низкая масса тела очень низкая масса тела открытый артериальный проток |
| url | https://mednauki.ru/index.php/MD/article/view/1204 |
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