Gingival spatial analysis reveals geographic immunological variation in a microbiota-dependent and -independent manner
Abstract In mucosal barriers, tissue cells and leukocytes collaborate to form specialized niches that support host-microbiome symbiosis. Understanding the spatial organization of these barriers is crucial for elucidating the mechanisms underlying health and disease. The gingiva, a unique mucosal bar...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-12-01
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| Series: | npj Biofilms and Microbiomes |
| Online Access: | https://doi.org/10.1038/s41522-024-00625-2 |
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| author | Yasmin Jaber Avital Sarusi-Portuguez Yasmin Netanely Reem Naamneh Shahd Yacoub Or Saar Nadeem Darawshi Luba Eli-Berchoer Hagit Shapiro Eran Elinav Asaf Wilensky Avi-Hai Hovav |
| author_facet | Yasmin Jaber Avital Sarusi-Portuguez Yasmin Netanely Reem Naamneh Shahd Yacoub Or Saar Nadeem Darawshi Luba Eli-Berchoer Hagit Shapiro Eran Elinav Asaf Wilensky Avi-Hai Hovav |
| author_sort | Yasmin Jaber |
| collection | DOAJ |
| description | Abstract In mucosal barriers, tissue cells and leukocytes collaborate to form specialized niches that support host-microbiome symbiosis. Understanding the spatial organization of these barriers is crucial for elucidating the mechanisms underlying health and disease. The gingiva, a unique mucosal barrier with significant health implications, exhibits intricate tissue architecture and likely contains specialized immunological regions. Through spatial transcriptomic analysis, this study reveals distinct immunological characteristics between the buccal and palate regions of the murine gingiva, impacting natural alveolar bone loss. The microbiota primarily affects gingival immunity in the buccal region. Additionally, a significant influence of the microbiota on the junctional epithelium facing the oral biofilm offers new insights into neutrophil recruitment. The microbiota also regulates the proliferation and barrier-sealing function of the gingival epithelium. This underscores the presence of immunological niches in the gingiva, with the microbiota differentially influencing them, highlighting the high complexity of this oral mucosal barrier. |
| format | Article |
| id | doaj-art-d98755d21aef448bacf40001d9f20df7 |
| institution | Kabale University |
| issn | 2055-5008 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Biofilms and Microbiomes |
| spelling | doaj-art-d98755d21aef448bacf40001d9f20df72025-01-05T12:10:08ZengNature Portfolionpj Biofilms and Microbiomes2055-50082024-12-0110111510.1038/s41522-024-00625-2Gingival spatial analysis reveals geographic immunological variation in a microbiota-dependent and -independent mannerYasmin Jaber0Avital Sarusi-Portuguez1Yasmin Netanely2Reem Naamneh3Shahd Yacoub4Or Saar5Nadeem Darawshi6Luba Eli-Berchoer7Hagit Shapiro8Eran Elinav9Asaf Wilensky10Avi-Hai Hovav11Institute of Biomedical and Oral Research, Faculty of Dental Medicine, Hebrew UniversityLife Sciences Core Facilities, Weizmann Institute of ScienceInstitute of Biomedical and Oral Research, Faculty of Dental Medicine, Hebrew UniversityInstitute of Biomedical and Oral Research, Faculty of Dental Medicine, Hebrew UniversityInstitute of Biomedical and Oral Research, Faculty of Dental Medicine, Hebrew UniversityFaculty of Dental Medicine, Hebrew University, Jerusalem, Israel; Department of Periodontology, Hadassah Medical CenterInstitute of Biomedical and Oral Research, Faculty of Dental Medicine, Hebrew UniversityInstitute of Biomedical and Oral Research, Faculty of Dental Medicine, Hebrew UniversityDepartment of Systems Immunology, Weizmann Institute of ScienceDepartment of Systems Immunology, Weizmann Institute of ScienceLife Sciences Core Facilities, Weizmann Institute of ScienceInstitute of Biomedical and Oral Research, Faculty of Dental Medicine, Hebrew UniversityAbstract In mucosal barriers, tissue cells and leukocytes collaborate to form specialized niches that support host-microbiome symbiosis. Understanding the spatial organization of these barriers is crucial for elucidating the mechanisms underlying health and disease. The gingiva, a unique mucosal barrier with significant health implications, exhibits intricate tissue architecture and likely contains specialized immunological regions. Through spatial transcriptomic analysis, this study reveals distinct immunological characteristics between the buccal and palate regions of the murine gingiva, impacting natural alveolar bone loss. The microbiota primarily affects gingival immunity in the buccal region. Additionally, a significant influence of the microbiota on the junctional epithelium facing the oral biofilm offers new insights into neutrophil recruitment. The microbiota also regulates the proliferation and barrier-sealing function of the gingival epithelium. This underscores the presence of immunological niches in the gingiva, with the microbiota differentially influencing them, highlighting the high complexity of this oral mucosal barrier.https://doi.org/10.1038/s41522-024-00625-2 |
| spellingShingle | Yasmin Jaber Avital Sarusi-Portuguez Yasmin Netanely Reem Naamneh Shahd Yacoub Or Saar Nadeem Darawshi Luba Eli-Berchoer Hagit Shapiro Eran Elinav Asaf Wilensky Avi-Hai Hovav Gingival spatial analysis reveals geographic immunological variation in a microbiota-dependent and -independent manner npj Biofilms and Microbiomes |
| title | Gingival spatial analysis reveals geographic immunological variation in a microbiota-dependent and -independent manner |
| title_full | Gingival spatial analysis reveals geographic immunological variation in a microbiota-dependent and -independent manner |
| title_fullStr | Gingival spatial analysis reveals geographic immunological variation in a microbiota-dependent and -independent manner |
| title_full_unstemmed | Gingival spatial analysis reveals geographic immunological variation in a microbiota-dependent and -independent manner |
| title_short | Gingival spatial analysis reveals geographic immunological variation in a microbiota-dependent and -independent manner |
| title_sort | gingival spatial analysis reveals geographic immunological variation in a microbiota dependent and independent manner |
| url | https://doi.org/10.1038/s41522-024-00625-2 |
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