High-throughput clinical antimicrobial susceptibility testing and drug-resistant subpopulation detection in Gram-negative bacteria

High-throughput clinical antimicrobial susceptibility testing and drug-resistant subpopulation detection in Gram-negative bacteria

ABSTRACT The optimized Easy and Zooming MTT (EZMTT)-based antimicrobial susceptibility testing (AST) method for Gram-negative bacteria demonstrated 5- to 20-fold enhanced sensitivity and improved the detection limit to approximately 1.13% ± 0.30% growth. This advancement enables the detection of dru...

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Main Authors: QingFeng Hu, Yuhan Zhou, Yongze Zhu, Zixuan Ma, Tongtong Li, Shuhang Yao, Ju Pan, Mengyan Shi, Fang Su, Beiqiong Shen, Xi Li, Benfang Helen Ruan, Jiaxue Wang
Format: Article
Language:English
Published: American Society for Microbiology 2025-07-01
Series:Microbiology Spectrum
Subjects:
Gram-negative bacteria
antimicrobial susceptibility testing
heteroresistance
AST
drug-resistant bacterial subpopulation
EZMTT
Online Access:https://journals.asm.org/doi/10.1128/spectrum.00011-25
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https://journals.asm.org/doi/10.1128/spectrum.00011-25

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