A Man with Rapidly Progressive Limb Gangrene
Antiphospholipid syndrome (APS) and polyarteritis nodosa (PAN) are two distinct, but potentially overlapping, autoimmune disorders that are characterized by vascular morbidities. We present a case of probable APS that manifested as rapidly progressive peripheral gangrene with a positive test for lup...
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| Format: | Article |
| Language: | English |
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World Scientific Publishing
2024-12-01
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| Series: | Journal of Clinical Rheumatology and Immunology |
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| Online Access: | https://www.worldscientific.com/doi/10.1142/S2661341724720039 |
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| _version_ | 1832539932849078272 |
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| author | Ada Wing Tung Leung Virginia Weng Nga Lao |
| author_facet | Ada Wing Tung Leung Virginia Weng Nga Lao |
| author_sort | Ada Wing Tung Leung |
| collection | DOAJ |
| description | Antiphospholipid syndrome (APS) and polyarteritis nodosa (PAN) are two distinct, but potentially overlapping, autoimmune disorders that are characterized by vascular morbidities. We present a case of probable APS that manifested as rapidly progressive peripheral gangrene with a positive test for lupus anticoagulant (LAC), alongside with angiographic evidence of suspected renal and hepatic artery aneurysms commonly associated with PAN, but also the presence of diffuse thrombosis over the distal arterial branches in the four limbs. Through this case, we aim to review the overlapping features and potential interplay between APS and PAN, highlighting the necessary considerations for optimizing management to salvage the ongoing limb ischemia. |
| format | Article |
| id | doaj-art-d97b6fca9dba4aa68e797f99ff2ae99e |
| institution | Kabale University |
| issn | 2661-3417 2661-3425 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | World Scientific Publishing |
| record_format | Article |
| series | Journal of Clinical Rheumatology and Immunology |
| spelling | doaj-art-d97b6fca9dba4aa68e797f99ff2ae99e2025-02-05T07:39:34ZengWorld Scientific PublishingJournal of Clinical Rheumatology and Immunology2661-34172661-34252024-12-012402788310.1142/S2661341724720039A Man with Rapidly Progressive Limb GangreneAda Wing Tung Leung0Virginia Weng Nga Lao1Department of Medicine and Geriatrics, Kwong Wah Hospital, Hong Kong SAR, ChinaDepartment of Medicine and Geriatrics, Kwong Wah Hospital, Hong Kong SAR, ChinaAntiphospholipid syndrome (APS) and polyarteritis nodosa (PAN) are two distinct, but potentially overlapping, autoimmune disorders that are characterized by vascular morbidities. We present a case of probable APS that manifested as rapidly progressive peripheral gangrene with a positive test for lupus anticoagulant (LAC), alongside with angiographic evidence of suspected renal and hepatic artery aneurysms commonly associated with PAN, but also the presence of diffuse thrombosis over the distal arterial branches in the four limbs. Through this case, we aim to review the overlapping features and potential interplay between APS and PAN, highlighting the necessary considerations for optimizing management to salvage the ongoing limb ischemia.https://www.worldscientific.com/doi/10.1142/S2661341724720039Antiphospholipid SyndromePolyarteritis NodosaPeripheral Gangrene |
| spellingShingle | Ada Wing Tung Leung Virginia Weng Nga Lao A Man with Rapidly Progressive Limb Gangrene Journal of Clinical Rheumatology and Immunology Antiphospholipid Syndrome Polyarteritis Nodosa Peripheral Gangrene |
| title | A Man with Rapidly Progressive Limb Gangrene |
| title_full | A Man with Rapidly Progressive Limb Gangrene |
| title_fullStr | A Man with Rapidly Progressive Limb Gangrene |
| title_full_unstemmed | A Man with Rapidly Progressive Limb Gangrene |
| title_short | A Man with Rapidly Progressive Limb Gangrene |
| title_sort | man with rapidly progressive limb gangrene |
| topic | Antiphospholipid Syndrome Polyarteritis Nodosa Peripheral Gangrene |
| url | https://www.worldscientific.com/doi/10.1142/S2661341724720039 |
| work_keys_str_mv | AT adawingtungleung amanwithrapidlyprogressivelimbgangrene AT virginiawengngalao amanwithrapidlyprogressivelimbgangrene AT adawingtungleung manwithrapidlyprogressivelimbgangrene AT virginiawengngalao manwithrapidlyprogressivelimbgangrene |