Evaluating the effect of nutritional support in geriatric inpatients classified by the GLIM criteria
Objectives: In this study, we aimed to explore the impact of nutrition therapy on clinical outcomes for patients classified according to the Global Leadership Initiative on Malnutrition (GLIM) criteria. Design: Prospective, multicenter cohort study. Setting: This study was conducted from September 2...
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Elsevier
2025-08-01
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| Series: | The Journal of Nutrition, Health and Aging |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1279770725001101 |
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| author | Shan Jiang Xiling Chen Lan Ma Qihao Guo Lan Luo Yuehui Wang Xuan Qu Jiaojiao Li Liping An Wei Huang Yonghua Wu Hongyu Zhang Cuntai Zhang Yun Fan Songbai Zheng Jian Cao Xiaohong Liu |
| author_facet | Shan Jiang Xiling Chen Lan Ma Qihao Guo Lan Luo Yuehui Wang Xuan Qu Jiaojiao Li Liping An Wei Huang Yonghua Wu Hongyu Zhang Cuntai Zhang Yun Fan Songbai Zheng Jian Cao Xiaohong Liu |
| author_sort | Shan Jiang |
| collection | DOAJ |
| description | Objectives: In this study, we aimed to explore the impact of nutrition therapy on clinical outcomes for patients classified according to the Global Leadership Initiative on Malnutrition (GLIM) criteria. Design: Prospective, multicenter cohort study. Setting: This study was conducted from September 2020 to December 2022 across 28 geriatric centers in China. Participants: A total of 862 patients aged ≥65 years were included. Intervention: All participating physicians completed a 6-h training on nutritional support, following international guidelines before the study. Patients had a nutritional risk screening 2002 score ≥3 points within 48 h of admission. Physicians determined specific nutritional support regimens. Measurements: GLIM assessments were conducted after enrollment. Nutritional and functional statuses were evaluated at baseline and 90 days after admission. Clinical outcomes—mortality, readmission, new infections, and falls—were documented after 90 days. Results: Compared to 108 patients without malnutrition per the GLIM criteria, 754 malnourished patients showed lower weight, body mass index (BMI), and Mini Nutritional Assessment-Short Form (MNA-SF) scores and significant reductions in grip strength, calf circumference, and Barthel activities of daily living (ADLs) index. The percentage of patients with adequate caloric intake at the 90-day follow-up was 70.7% (n = 533) and 67.6% (n = 73) in the malnutrition and non-malnutrition groups (p = 0.51) and that of patients with adequate protein intake was 65.9% (n = 497) and 58.3% (n = 63), respectively (p = 0.12). Moreover, malnourished patients showed significant improvements in body weight, BMI, MNA-SF scores, calf circumference, and Barthel ADL index compared to those without malnutrition. Malnourished patients also had lower risks of readmission and falls at follow-up. Conclusion: Among older inpatients at nutritional risk, those with malnutrition classified according to the GLIM criteria benefited from nutritional support, demonstrating improved BMI, MNA-SF scores, calf circumference, and Barthel ADL index, as well as reduced readmission rates and incidence of falls. |
| format | Article |
| id | doaj-art-d97a0b619ca048b7af288b30b3c86e6b |
| institution | OA Journals |
| issn | 1760-4788 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Elsevier |
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| series | The Journal of Nutrition, Health and Aging |
| spelling | doaj-art-d97a0b619ca048b7af288b30b3c86e6b2025-08-20T02:26:10ZengElsevierThe Journal of Nutrition, Health and Aging1760-47882025-08-0129810058510.1016/j.jnha.2025.100585Evaluating the effect of nutritional support in geriatric inpatients classified by the GLIM criteriaShan Jiang0Xiling Chen1Lan Ma2Qihao Guo3Lan Luo4Yuehui Wang5Xuan Qu6Jiaojiao Li7Liping An8Wei Huang9Yonghua Wu10Hongyu Zhang11Cuntai Zhang12Yun Fan13Songbai Zheng14Jian Cao15Xiaohong Liu16Department of Geriatrics, Chinese Academy of Medical Sciences, Peking Union Medical College Hospital, No. 1 Shuaifuyuan, Dongcheng District, Beijing 100730, ChinaDepartment of Geriatrics, The Second Affiliated Hospital of Zhengzhou University, No.2, Jingba Road, Jinshui District, Zhengzhou 450003, Henan, ChinaDepartment of Geriatrics, The Second Affiliated Hospital of Harbin Medical University, No.246, Xuefu Road, Nangang District, Harbin 150086, Heilongjiang, ChinaDepartment of Geriatrics, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University School of Medicine, No.600, Yishan Road, Xuhui District, Shanghai 200233, ChinaDepartment of Geriatrics, Affiliated Hospital of Nantong University, No. 20, Xisi Road, Chongshan District, Nantong 226006, Jiangsu, ChinaDepartment of Geriatrics, The First Hospital of Jilin University, No. 1, Xinmin Road, Chaoyang District, Changchun 130021, Jilin, ChinaDepartment of Geriatrics, Chinese Academy of Medical Sciences, Peking Union Medical College Hospital, No. 1 Shuaifuyuan, Dongcheng District, Beijing 100730, ChinaDepartment of Geriatrics, Chinese Academy of Medical Sciences, Peking Union Medical College Hospital, No. 1 Shuaifuyuan, Dongcheng District, Beijing 100730, ChinaDepartment of Geriatrics, Heilongjiang Provincial Hospital, No. 82, Zhongshan Road, Xiangfang District, Harbin 151100, Heilongjiang, ChinaDepartment of Geriatrics, Tangshan Gongren Hospital, No. 27, Wenhua Road, Lubei District, Tangshan 063099, Hebei, ChinaDepartment of Geriatrics, Suzhou Municipal Hospital, No. 26, Daoqian Road, Gusu District, Suzhou 215002, Jiangsu, ChinaDepartment of Geriatrics, Qilu Hospital of Shandong University, No. 107, Wenhua West Road, Lixia District, Jinan 250012, Shandong, ChinaDepartment of Geriatrics, Huazhong University of Science and Technology Tongji Hospital, No. 1095, Jiefang Avenue, Qiaokou District, Wuhan 430030, Hubei, ChinaDepartment of Geriatrics, Beijing Hospital, No. 1, Dahua Road, Dongcheng District, Beijing 100005, ChinaDepartment of Geriatrics, Huadong Hospital Affiliated to Fudan University, No. 221, Yan'an West Road, Jingan District, Shanghai 200040, ChinaDepartment of Geriatrics, The Second Medical Center, The National Clinical Research Center for Geriatric Diseases, Chinese People’s Liberation Army General Hospital, No. 28, Fuxing Road, Haidian District, Beijing 100853, ChinaDepartment of Geriatrics, Chinese Academy of Medical Sciences, Peking Union Medical College Hospital, No. 1 Shuaifuyuan, Dongcheng District, Beijing 100730, China; Corresponding author at: Department of Geriatrics, Chinese Academy of Medical Sciences, Peking Union Medical College Hospital, No. 1 Shuaifuyuan, Dong Cheng District, Beijing 100730, China.Objectives: In this study, we aimed to explore the impact of nutrition therapy on clinical outcomes for patients classified according to the Global Leadership Initiative on Malnutrition (GLIM) criteria. Design: Prospective, multicenter cohort study. Setting: This study was conducted from September 2020 to December 2022 across 28 geriatric centers in China. Participants: A total of 862 patients aged ≥65 years were included. Intervention: All participating physicians completed a 6-h training on nutritional support, following international guidelines before the study. Patients had a nutritional risk screening 2002 score ≥3 points within 48 h of admission. Physicians determined specific nutritional support regimens. Measurements: GLIM assessments were conducted after enrollment. Nutritional and functional statuses were evaluated at baseline and 90 days after admission. Clinical outcomes—mortality, readmission, new infections, and falls—were documented after 90 days. Results: Compared to 108 patients without malnutrition per the GLIM criteria, 754 malnourished patients showed lower weight, body mass index (BMI), and Mini Nutritional Assessment-Short Form (MNA-SF) scores and significant reductions in grip strength, calf circumference, and Barthel activities of daily living (ADLs) index. The percentage of patients with adequate caloric intake at the 90-day follow-up was 70.7% (n = 533) and 67.6% (n = 73) in the malnutrition and non-malnutrition groups (p = 0.51) and that of patients with adequate protein intake was 65.9% (n = 497) and 58.3% (n = 63), respectively (p = 0.12). Moreover, malnourished patients showed significant improvements in body weight, BMI, MNA-SF scores, calf circumference, and Barthel ADL index compared to those without malnutrition. Malnourished patients also had lower risks of readmission and falls at follow-up. Conclusion: Among older inpatients at nutritional risk, those with malnutrition classified according to the GLIM criteria benefited from nutritional support, demonstrating improved BMI, MNA-SF scores, calf circumference, and Barthel ADL index, as well as reduced readmission rates and incidence of falls.http://www.sciencedirect.com/science/article/pii/S1279770725001101GLIM criteriaMalnutritionNutritional support therapyOlder inpatients |
| spellingShingle | Shan Jiang Xiling Chen Lan Ma Qihao Guo Lan Luo Yuehui Wang Xuan Qu Jiaojiao Li Liping An Wei Huang Yonghua Wu Hongyu Zhang Cuntai Zhang Yun Fan Songbai Zheng Jian Cao Xiaohong Liu Evaluating the effect of nutritional support in geriatric inpatients classified by the GLIM criteria The Journal of Nutrition, Health and Aging GLIM criteria Malnutrition Nutritional support therapy Older inpatients |
| title | Evaluating the effect of nutritional support in geriatric inpatients classified by the GLIM criteria |
| title_full | Evaluating the effect of nutritional support in geriatric inpatients classified by the GLIM criteria |
| title_fullStr | Evaluating the effect of nutritional support in geriatric inpatients classified by the GLIM criteria |
| title_full_unstemmed | Evaluating the effect of nutritional support in geriatric inpatients classified by the GLIM criteria |
| title_short | Evaluating the effect of nutritional support in geriatric inpatients classified by the GLIM criteria |
| title_sort | evaluating the effect of nutritional support in geriatric inpatients classified by the glim criteria |
| topic | GLIM criteria Malnutrition Nutritional support therapy Older inpatients |
| url | http://www.sciencedirect.com/science/article/pii/S1279770725001101 |
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