Synthesis, Characterization and Antibacterial activity of Benzimidazole Derivatives and their Cu (ii),Ni (ii) and Co (ii) complexes
Benzimidazole is one of the privileged nitrogen-containing heterocyclic compounds, which is found in many bioactive compounds, benzimidazole and its derivatives have evolved as an important heterocyclic system due to their potency in a wide range of biologically active compounds like anthelmintic,...
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Hawassa University
2023-04-01
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| Series: | East African Journal of Biophysical and Computational Sciences |
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| Online Access: | https://www.Ajol.Info/index.php/eajbcs/article/view/248702 |
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| author | Haftom Welderufael Dagne Addisu Kure Endalkachew Asefa Moges Lelisa File Salah Hamza Sherif |
| author_facet | Haftom Welderufael Dagne Addisu Kure Endalkachew Asefa Moges Lelisa File Salah Hamza Sherif |
| author_sort | Haftom Welderufael |
| collection | DOAJ |
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Benzimidazole is one of the privileged nitrogen-containing heterocyclic compounds, which is found in many bioactive compounds, benzimidazole and its derivatives have evolved as an important heterocyclic system due to their potency in a wide range of biologically active compounds like anthelmintic, antibacterial, antifungals, anti-inflammatory, antiviral, and so on. Derivatives of 1-arylsulfonylbenzimidazole and their respective Cu (II), Ni (II) and Co (II) complexes were successfully synthesized. The structures of all the synthesized ligands were confirmed by using IR, UV-Visible, 1H NMR, and 13C NMR spectroscopy. The Cu (II), Ni (II) and Co (II) complexes were confirmed by using IR and VU-Visible spectra. The IR spectra of ligands and its metal complexes imply that the benzimidazol derivative ligands behave as basic bidentate ligands coordination through the azomethine nitrogen and oxygen atom. In-vitro antibacterial activity of all the synthesized ligands and their metal complexes were evaluated by using disc diffusion method against K. pneumoniae, E. coli, and S. aureus bacterial species .The tested compounds and metal complexes exhibited from good to excellent activity (zone of inhibition (ZI) ranged 10 mm to 23 mm). Compound BIL1 exhibited better activity than the standard drug against E. coli (ZI of 15 mm) and K. pneumoniae (ZI of 5 mm)compared with gentamycin ((ZI of 15mm). Complex CoC exhibited better activity against S. aureus (ZI of 23 mm) compared with gentamicine (ZI value of 21 mm). This compound is a good starting point to develop new drug for treating pathogenic diseases. Therefore, synthesis of more analogue were recommended for further discovery of a new drug candidate.
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| format | Article |
| id | doaj-art-d976ea4069fc4f2f96aae3f8d2069acc |
| institution | Kabale University |
| issn | 2789-360X 2789-3618 |
| language | English |
| publishDate | 2023-04-01 |
| publisher | Hawassa University |
| record_format | Article |
| series | East African Journal of Biophysical and Computational Sciences |
| spelling | doaj-art-d976ea4069fc4f2f96aae3f8d2069acc2025-02-08T19:51:01ZengHawassa UniversityEast African Journal of Biophysical and Computational Sciences2789-360X2789-36182023-04-0141Synthesis, Characterization and Antibacterial activity of Benzimidazole Derivatives and their Cu (ii),Ni (ii) and Co (ii) complexes Haftom Welderufael0 Dagne Addisu Kure1Endalkachew Asefa Moges2Lelisa File3Salah Hamza Sherif 4Department of Chemistry, Hawassa University, Hawassa, EthiopiaDepartment of Chemistry, Hawassa University, Hawassa, EthiopiaDepartment of Chemistry, Hawassa University, Hawassa, EthiopiaDepartment of Chemistry, Hawassa University, Hawassa, EthiopiaDepartment of Chemistry, Hawassa University, Hawassa, Ethiopia Benzimidazole is one of the privileged nitrogen-containing heterocyclic compounds, which is found in many bioactive compounds, benzimidazole and its derivatives have evolved as an important heterocyclic system due to their potency in a wide range of biologically active compounds like anthelmintic, antibacterial, antifungals, anti-inflammatory, antiviral, and so on. Derivatives of 1-arylsulfonylbenzimidazole and their respective Cu (II), Ni (II) and Co (II) complexes were successfully synthesized. The structures of all the synthesized ligands were confirmed by using IR, UV-Visible, 1H NMR, and 13C NMR spectroscopy. The Cu (II), Ni (II) and Co (II) complexes were confirmed by using IR and VU-Visible spectra. The IR spectra of ligands and its metal complexes imply that the benzimidazol derivative ligands behave as basic bidentate ligands coordination through the azomethine nitrogen and oxygen atom. In-vitro antibacterial activity of all the synthesized ligands and their metal complexes were evaluated by using disc diffusion method against K. pneumoniae, E. coli, and S. aureus bacterial species .The tested compounds and metal complexes exhibited from good to excellent activity (zone of inhibition (ZI) ranged 10 mm to 23 mm). Compound BIL1 exhibited better activity than the standard drug against E. coli (ZI of 15 mm) and K. pneumoniae (ZI of 5 mm)compared with gentamycin ((ZI of 15mm). Complex CoC exhibited better activity against S. aureus (ZI of 23 mm) compared with gentamicine (ZI value of 21 mm). This compound is a good starting point to develop new drug for treating pathogenic diseases. Therefore, synthesis of more analogue were recommended for further discovery of a new drug candidate. https://www.Ajol.Info/index.php/eajbcs/article/view/248702Antibacterial; Benzimidazole; Metal complex; Schiff base |
| spellingShingle | Haftom Welderufael Dagne Addisu Kure Endalkachew Asefa Moges Lelisa File Salah Hamza Sherif Synthesis, Characterization and Antibacterial activity of Benzimidazole Derivatives and their Cu (ii),Ni (ii) and Co (ii) complexes East African Journal of Biophysical and Computational Sciences Antibacterial; Benzimidazole; Metal complex; Schiff base |
| title | Synthesis, Characterization and Antibacterial activity of Benzimidazole Derivatives and their Cu (ii),Ni (ii) and Co (ii) complexes |
| title_full | Synthesis, Characterization and Antibacterial activity of Benzimidazole Derivatives and their Cu (ii),Ni (ii) and Co (ii) complexes |
| title_fullStr | Synthesis, Characterization and Antibacterial activity of Benzimidazole Derivatives and their Cu (ii),Ni (ii) and Co (ii) complexes |
| title_full_unstemmed | Synthesis, Characterization and Antibacterial activity of Benzimidazole Derivatives and their Cu (ii),Ni (ii) and Co (ii) complexes |
| title_short | Synthesis, Characterization and Antibacterial activity of Benzimidazole Derivatives and their Cu (ii),Ni (ii) and Co (ii) complexes |
| title_sort | synthesis characterization and antibacterial activity of benzimidazole derivatives and their cu ii ni ii and co ii complexes |
| topic | Antibacterial; Benzimidazole; Metal complex; Schiff base |
| url | https://www.Ajol.Info/index.php/eajbcs/article/view/248702 |
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