Analyzing food supplements to enhance erectile system function for the presence of undeclared sildenafil and tadalafil using HPLC-DAD
Phosphodiesterase-5 (PDE-5) inhibitors, such as sildenafil and tadalafil, are drugs commonly used to improve erectile function. However, some erectile function-enhancing supplements with claims of being entirely natural may be adulterated with these drugs, posing health risks. This study screened su...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Serbian Chemical Society
2025-01-01
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| Series: | Journal of the Serbian Chemical Society |
| Subjects: | |
| Online Access: | https://doiserbia.nb.rs/img/doi/0352-5139/2025/0352-51392500032B.pdf |
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| Summary: | Phosphodiesterase-5 (PDE-5) inhibitors, such as sildenafil and tadalafil, are drugs commonly used to improve erectile function. However, some erectile function-enhancing supplements with claims of being entirely natural may be adulterated with these drugs, posing health risks. This study screened supplements for erectile dysfunction from the Republic of North Macedonia using a fast, specific and sensitive HPLC-DAD method (runtime: 15 min). No interference was observed at the retention times of sildenafil and tadalafil, allowing for their unambiguous identification and quantification. Tadalafil was absent, but sildenafil was found in two of eight samples (32.78 and 13.47 mg per dosage). The results demonstrated the applicability of the method to determine whether food supplements marked for the erectile function enhancement are free of sildenafil and tadalafil. |
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| ISSN: | 0352-5139 1820-7421 |