The evolution of vestibular function and health-related quality of life in bilateral vestibulopathy
Abstract Little is known about the evolution of vestibular dysfunction and health-related quality of life in bilateral vestibulopathy patients over time. Furthermore, it is unknown whether etiology influences the evolution. A retrospective study was performed investigating the vestibular function at...
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Nature Portfolio
2025-03-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-92109-2 |
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| author | E. Loos L. Van Stiphout F. Lucieer Nils Guinand Angelica Pérez-Fornos Vincent Van Rompaey C. Desloovere S. Denys N. Verhaert R. van de Berg |
| author_facet | E. Loos L. Van Stiphout F. Lucieer Nils Guinand Angelica Pérez-Fornos Vincent Van Rompaey C. Desloovere S. Denys N. Verhaert R. van de Berg |
| author_sort | E. Loos |
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| description | Abstract Little is known about the evolution of vestibular dysfunction and health-related quality of life in bilateral vestibulopathy patients over time. Furthermore, it is unknown whether etiology influences the evolution. A retrospective study was performed investigating the vestibular function at two different time points during a median follow-up time of 24 months in 97 bilateral vestibulopathy patients. Additionally, to evaluate the quality of life and symptoms, validated questionnaires were analyzed. The sum of the caloric testing on the right side and the gain of the rotatory chair torsion swing test significantly decreased over time (p = 0.020 and p = 0.017, respectively). The left-sided caloric tests remained stable, but the median was already 0°/sec at baseline testing. On the contrary, vHIT gain significantly improved on both sides during follow-up (right: p = 0.003, left: p = 0.000). However, the median differences were not clinically relevant. Only two patients (2%) who improved on caloric testing, failed to reach the criteria for bilateral vestibulopathy at follow-up. Both patients had idiopathic bilateral vestibulopathy. At baseline, these patients did already not comply with the criteria for bilateral vestibulopathy based on the vHIT and/or torsion swing test. There was no significant change in the total DHI, EQ-5D-5 L VAS, or HADS scores. The EQ-5D-5 L index significantly increased (p = 0.034). No significant relationship could be determined between etiology and the evolution of vestibular function, quality of life, and symptoms. In conclusion, in the majority of bilateral vestibulopathy patients, vestibular function, health-related quality of life and symptoms did not show a clinically relevant improvement over time. |
| format | Article |
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| issn | 2045-2322 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-d96f7f79e29f418095cf6470ddd6481a2025-08-20T01:57:25ZengNature PortfolioScientific Reports2045-23222025-03-0115111110.1038/s41598-025-92109-2The evolution of vestibular function and health-related quality of life in bilateral vestibulopathyE. Loos0L. Van Stiphout1F. Lucieer2Nils Guinand3Angelica Pérez-Fornos4Vincent Van Rompaey5C. Desloovere6S. Denys7N. Verhaert8R. van de Berg9Department of Otorhinolaryngology-Head and Neck Surgery, School for Mental Health and Neuroscience (MHeNS), Faculty of Health Medicine and Life Sciences, Maastricht University Medical CenterDepartment of Otorhinolaryngology-Head and Neck Surgery, School for Mental Health and Neuroscience (MHeNS), Faculty of Health Medicine and Life Sciences, Maastricht University Medical CenterDepartment of Otorhinolaryngology-Head and Neck Surgery, School for Mental Health and Neuroscience (MHeNS), Faculty of Health Medicine and Life Sciences, Maastricht University Medical CenterDepartment of Otorhinolaryngology-Head and Neck Surgery, Department of Clinical Neurosciences, Geneva University HospitalsDepartment of Otorhinolaryngology-Head and Neck Surgery, Department of Clinical Neurosciences, Geneva University HospitalsFaculty of Medicine and Health Sciences, University of AntwerpDepartment of Otorhinolaryngology-Head and Neck Surgery, University Hospitals LeuvenDepartment of Otorhinolaryngology-Head and Neck Surgery, University Hospitals LeuvenDepartment of Otorhinolaryngology-Head and Neck Surgery, University Hospitals LeuvenDepartment of Otorhinolaryngology-Head and Neck Surgery, School for Mental Health and Neuroscience (MHeNS), Faculty of Health Medicine and Life Sciences, Maastricht University Medical CenterAbstract Little is known about the evolution of vestibular dysfunction and health-related quality of life in bilateral vestibulopathy patients over time. Furthermore, it is unknown whether etiology influences the evolution. A retrospective study was performed investigating the vestibular function at two different time points during a median follow-up time of 24 months in 97 bilateral vestibulopathy patients. Additionally, to evaluate the quality of life and symptoms, validated questionnaires were analyzed. The sum of the caloric testing on the right side and the gain of the rotatory chair torsion swing test significantly decreased over time (p = 0.020 and p = 0.017, respectively). The left-sided caloric tests remained stable, but the median was already 0°/sec at baseline testing. On the contrary, vHIT gain significantly improved on both sides during follow-up (right: p = 0.003, left: p = 0.000). However, the median differences were not clinically relevant. Only two patients (2%) who improved on caloric testing, failed to reach the criteria for bilateral vestibulopathy at follow-up. Both patients had idiopathic bilateral vestibulopathy. At baseline, these patients did already not comply with the criteria for bilateral vestibulopathy based on the vHIT and/or torsion swing test. There was no significant change in the total DHI, EQ-5D-5 L VAS, or HADS scores. The EQ-5D-5 L index significantly increased (p = 0.034). No significant relationship could be determined between etiology and the evolution of vestibular function, quality of life, and symptoms. In conclusion, in the majority of bilateral vestibulopathy patients, vestibular function, health-related quality of life and symptoms did not show a clinically relevant improvement over time.https://doi.org/10.1038/s41598-025-92109-2Bilateral vestibulopathyBilateral vestibular hypofunctionBilateral vestibular lossBilateral vestibular areflexiaVestibular implantVertigo |
| spellingShingle | E. Loos L. Van Stiphout F. Lucieer Nils Guinand Angelica Pérez-Fornos Vincent Van Rompaey C. Desloovere S. Denys N. Verhaert R. van de Berg The evolution of vestibular function and health-related quality of life in bilateral vestibulopathy Scientific Reports Bilateral vestibulopathy Bilateral vestibular hypofunction Bilateral vestibular loss Bilateral vestibular areflexia Vestibular implant Vertigo |
| title | The evolution of vestibular function and health-related quality of life in bilateral vestibulopathy |
| title_full | The evolution of vestibular function and health-related quality of life in bilateral vestibulopathy |
| title_fullStr | The evolution of vestibular function and health-related quality of life in bilateral vestibulopathy |
| title_full_unstemmed | The evolution of vestibular function and health-related quality of life in bilateral vestibulopathy |
| title_short | The evolution of vestibular function and health-related quality of life in bilateral vestibulopathy |
| title_sort | evolution of vestibular function and health related quality of life in bilateral vestibulopathy |
| topic | Bilateral vestibulopathy Bilateral vestibular hypofunction Bilateral vestibular loss Bilateral vestibular areflexia Vestibular implant Vertigo |
| url | https://doi.org/10.1038/s41598-025-92109-2 |
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