Toxicity Estimation of Unspecific Medicinal Antiviral Agents for Prophylaxis and Therapy of Hazard and Especially Hazard Viral Infections
Cytotoxicity of chemotherapeutics (Ribavirin®, Remantadin® and Ingavirin®), interferon (Realdiron®) and interferon inductors (Larifan®, Ridostin®, Arbidol® and Cytarabin®) was investigated with the use of persistent and diploid cell cultures. Ingavirin® and Ribavirin® from the group of the chemother...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
LLC "Publishing House OKI"
2020-05-01
|
| Series: | Антибиотики и Химиотерапия |
| Subjects: | |
| Online Access: | https://www.antibiotics-chemotherapy.ru/jour/article/view/213 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849389148986671104 |
|---|---|
| author | S. YA. Loginova S. V. Borisevich V. A. Maksimov V. P. Bondarev |
| author_facet | S. YA. Loginova S. V. Borisevich V. A. Maksimov V. P. Bondarev |
| author_sort | S. YA. Loginova |
| collection | DOAJ |
| description | Cytotoxicity of chemotherapeutics (Ribavirin®, Remantadin® and Ingavirin®), interferon (Realdiron®) and interferon inductors (Larifan®, Ridostin®, Arbidol® and Cytarabin®) was investigated with the use of persistent and diploid cell cultures. Ingavirin® and Ribavirin® from the group of the chemotherapeutics and Razifan® and Ridostin® from the group of the interferon inducrors showed the lowest toxicity. Light microscopy revealed no visible cytopathic changes in the investigation cell cultures exposed to maximum concentrations (≥106 IU) of Realdiron®. In vivo acute toxicity investigation demonstrated that in a concentration of 106 IU per animal weight Realdiron® was not toxic for the albino mice and chinchilla rabbits. The maximum tolerance doses for the albino mice were the following: ≥3000 mg/kg of Ingavirin®, 401.25 mg/kg of Arbidol®, 170 mg/kg of Ribavirin®, ≥100 mg/kg of Larifan® and ≥100 mg/kg of Ridostin®. |
| format | Article |
| id | doaj-art-d96caf234a3a4be69dbedd11eb9fd4fa |
| institution | Kabale University |
| issn | 0235-2990 |
| language | Russian |
| publishDate | 2020-05-01 |
| publisher | LLC "Publishing House OKI" |
| record_format | Article |
| series | Антибиотики и Химиотерапия |
| spelling | doaj-art-d96caf234a3a4be69dbedd11eb9fd4fa2025-08-20T03:42:02ZrusLLC "Publishing House OKI"Антибиотики и Химиотерапия0235-29902020-05-01543-41114212Toxicity Estimation of Unspecific Medicinal Antiviral Agents for Prophylaxis and Therapy of Hazard and Especially Hazard Viral InfectionsS. YA. Loginova0S. V. Borisevich1V. A. Maksimov2V. P. Bondarev3Branch of Central Research Institute No. 48, Ministry of Defense of the Russian Federation, Virological Centre, Sergiev PosadBranch of Central Research Institute No. 48, Ministry of Defense of the Russian Federation, Virological Centre, Sergiev PosadBranch of Central Research Institute No. 48, Ministry of Defense of the Russian Federation, Virological Centre, Sergiev PosadBranch of Central Research Institute No. 48, Ministry of Defense of the Russian Federation, Virological Centre, Sergiev PosadCytotoxicity of chemotherapeutics (Ribavirin®, Remantadin® and Ingavirin®), interferon (Realdiron®) and interferon inductors (Larifan®, Ridostin®, Arbidol® and Cytarabin®) was investigated with the use of persistent and diploid cell cultures. Ingavirin® and Ribavirin® from the group of the chemotherapeutics and Razifan® and Ridostin® from the group of the interferon inducrors showed the lowest toxicity. Light microscopy revealed no visible cytopathic changes in the investigation cell cultures exposed to maximum concentrations (≥106 IU) of Realdiron®. In vivo acute toxicity investigation demonstrated that in a concentration of 106 IU per animal weight Realdiron® was not toxic for the albino mice and chinchilla rabbits. The maximum tolerance doses for the albino mice were the following: ≥3000 mg/kg of Ingavirin®, 401.25 mg/kg of Arbidol®, 170 mg/kg of Ribavirin®, ≥100 mg/kg of Larifan® and ≥100 mg/kg of Ridostin®.https://www.antibiotics-chemotherapy.ru/jour/article/view/213cytotoxicityacute toxicitymaximum tolerance dosemaximum tolerance concentrationchemotherapeuticsinterferoninterferon inductors |
| spellingShingle | S. YA. Loginova S. V. Borisevich V. A. Maksimov V. P. Bondarev Toxicity Estimation of Unspecific Medicinal Antiviral Agents for Prophylaxis and Therapy of Hazard and Especially Hazard Viral Infections Антибиотики и Химиотерапия cytotoxicity acute toxicity maximum tolerance dose maximum tolerance concentration chemotherapeutics interferon interferon inductors |
| title | Toxicity Estimation of Unspecific Medicinal Antiviral Agents for Prophylaxis and Therapy of Hazard and Especially Hazard Viral Infections |
| title_full | Toxicity Estimation of Unspecific Medicinal Antiviral Agents for Prophylaxis and Therapy of Hazard and Especially Hazard Viral Infections |
| title_fullStr | Toxicity Estimation of Unspecific Medicinal Antiviral Agents for Prophylaxis and Therapy of Hazard and Especially Hazard Viral Infections |
| title_full_unstemmed | Toxicity Estimation of Unspecific Medicinal Antiviral Agents for Prophylaxis and Therapy of Hazard and Especially Hazard Viral Infections |
| title_short | Toxicity Estimation of Unspecific Medicinal Antiviral Agents for Prophylaxis and Therapy of Hazard and Especially Hazard Viral Infections |
| title_sort | toxicity estimation of unspecific medicinal antiviral agents for prophylaxis and therapy of hazard and especially hazard viral infections |
| topic | cytotoxicity acute toxicity maximum tolerance dose maximum tolerance concentration chemotherapeutics interferon interferon inductors |
| url | https://www.antibiotics-chemotherapy.ru/jour/article/view/213 |
| work_keys_str_mv | AT syaloginova toxicityestimationofunspecificmedicinalantiviralagentsforprophylaxisandtherapyofhazardandespeciallyhazardviralinfections AT svborisevich toxicityestimationofunspecificmedicinalantiviralagentsforprophylaxisandtherapyofhazardandespeciallyhazardviralinfections AT vamaksimov toxicityestimationofunspecificmedicinalantiviralagentsforprophylaxisandtherapyofhazardandespeciallyhazardviralinfections AT vpbondarev toxicityestimationofunspecificmedicinalantiviralagentsforprophylaxisandtherapyofhazardandespeciallyhazardviralinfections |