Piezo1 deletion mitigates diabetic cardiomyopathy by maintaining mitochondrial dynamics via ERK/Drp1 pathway

Piezo1 deletion mitigates diabetic cardiomyopathy by maintaining mitochondrial dynamics via ERK/Drp1 pathway

Abstract Objective Increasing evidence highlights the critical role of Piezo1 in cardiovascular diseases, with its expression upregulated in diabetic heart. However, the involvement of Piezo1 in the pathogenesis of diabetic cardiomyopathy (DCM) remains unclear. This study aims to elucidate the regul...

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Bibliographic Details
Main Authors: Weipin Niu, Xin Liu, Bo Deng, Tianying Hong, Cuifen Wang, Yameng Yan, Jiali Liu, Yuehua Jiang, Jing Li
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Cardiovascular Diabetology
Subjects:
Diabetic cardiomyopathy
Mitochondrial dynamics
Piezo1
ERK1/2
Drp1
Online Access:https://doi.org/10.1186/s12933-025-02625-8
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