Clinical and Capillaroscopic Modifications of the Psoriatic Plaque during Therapy: Observations with Oral Acitretin
Psoriasis is considered to be an inflammatory autoimmune disease, where angiogenesis plays an undefined pathogenetic role. The well-known changes of the superficial microvasculature in the psoriatic plaque can be easily assessed in vivo by videocapillaroscopy. In the last years, several studies repo...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Dermatology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2013/781942 |
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| author | Giuseppe Stinco Cinzia Buligan Enzo Errichetti Francesca Valent Pasquale Patrone |
| author_facet | Giuseppe Stinco Cinzia Buligan Enzo Errichetti Francesca Valent Pasquale Patrone |
| author_sort | Giuseppe Stinco |
| collection | DOAJ |
| description | Psoriasis is considered to be an inflammatory autoimmune disease, where angiogenesis plays an undefined pathogenetic role. The well-known changes of the superficial microvasculature in the psoriatic plaque can be easily assessed in vivo by videocapillaroscopy. In the last years, several studies reported the clinical and capillaroscopic response of the psoriatic plaque during different topical and systemic treatments. In the present work we evaluated the effects of acitretin (0.8 mg/kg/day) on videocapillaroscopic alterations and the clinical response in 11 patients affected by plaque psoriasis at the baseline (T0) and after 4 (T1), 8 (T2), and 12 (T3) weeks. A clinical improvement during the treatment with a complete clinical healing of the plaque in 7 of the 11 patients was observed. The typical “basket-weave” capillaries of the psoriatic lesions showed a reduction of 65.4% in diameter at the end of the study; only 3 patients returned to a normal capillaroscopic pattern. As observed during previous our studies, we found a discrepancy between clinical and capillaroscopic results, with a far greater improvement in the first than in the second. This finding could be in agreement with a secondary role of blood vessels in the pathogenesis and persistence of psoriatic lesions. |
| format | Article |
| id | doaj-art-d96b15694ac2451c9bffd7f513af899f |
| institution | Kabale University |
| issn | 1687-6105 1687-6113 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Dermatology Research and Practice |
| spelling | doaj-art-d96b15694ac2451c9bffd7f513af899f2025-02-03T01:31:22ZengWileyDermatology Research and Practice1687-61051687-61132013-01-01201310.1155/2013/781942781942Clinical and Capillaroscopic Modifications of the Psoriatic Plaque during Therapy: Observations with Oral AcitretinGiuseppe Stinco0Cinzia Buligan1Enzo Errichetti2Francesca Valent3Pasquale Patrone4Department of Experimental and Clinical Medicine,Institute of Dermatology, University of Udine, Ospedale “San Michele” di Gemona, Piazza Rodolone 1, Gemona del Friuli, 33013 Udine, ItalyDepartment of Experimental and Clinical Medicine,Institute of Dermatology, University of Udine, Ospedale “San Michele” di Gemona, Piazza Rodolone 1, Gemona del Friuli, 33013 Udine, ItalyDepartment of Experimental and Clinical Medicine,Institute of Dermatology, University of Udine, Ospedale “San Michele” di Gemona, Piazza Rodolone 1, Gemona del Friuli, 33013 Udine, ItalyDepartment of Medical and Biological Sciences, Institute of Hygiene and Clinical Epidemiology, University of Udine, via Colugna 50, 33100 Udine, ItalyDepartment of Experimental and Clinical Medicine,Institute of Dermatology, University of Udine, Ospedale “San Michele” di Gemona, Piazza Rodolone 1, Gemona del Friuli, 33013 Udine, ItalyPsoriasis is considered to be an inflammatory autoimmune disease, where angiogenesis plays an undefined pathogenetic role. The well-known changes of the superficial microvasculature in the psoriatic plaque can be easily assessed in vivo by videocapillaroscopy. In the last years, several studies reported the clinical and capillaroscopic response of the psoriatic plaque during different topical and systemic treatments. In the present work we evaluated the effects of acitretin (0.8 mg/kg/day) on videocapillaroscopic alterations and the clinical response in 11 patients affected by plaque psoriasis at the baseline (T0) and after 4 (T1), 8 (T2), and 12 (T3) weeks. A clinical improvement during the treatment with a complete clinical healing of the plaque in 7 of the 11 patients was observed. The typical “basket-weave” capillaries of the psoriatic lesions showed a reduction of 65.4% in diameter at the end of the study; only 3 patients returned to a normal capillaroscopic pattern. As observed during previous our studies, we found a discrepancy between clinical and capillaroscopic results, with a far greater improvement in the first than in the second. This finding could be in agreement with a secondary role of blood vessels in the pathogenesis and persistence of psoriatic lesions.http://dx.doi.org/10.1155/2013/781942 |
| spellingShingle | Giuseppe Stinco Cinzia Buligan Enzo Errichetti Francesca Valent Pasquale Patrone Clinical and Capillaroscopic Modifications of the Psoriatic Plaque during Therapy: Observations with Oral Acitretin Dermatology Research and Practice |
| title | Clinical and Capillaroscopic Modifications of the Psoriatic Plaque during Therapy: Observations with Oral Acitretin |
| title_full | Clinical and Capillaroscopic Modifications of the Psoriatic Plaque during Therapy: Observations with Oral Acitretin |
| title_fullStr | Clinical and Capillaroscopic Modifications of the Psoriatic Plaque during Therapy: Observations with Oral Acitretin |
| title_full_unstemmed | Clinical and Capillaroscopic Modifications of the Psoriatic Plaque during Therapy: Observations with Oral Acitretin |
| title_short | Clinical and Capillaroscopic Modifications of the Psoriatic Plaque during Therapy: Observations with Oral Acitretin |
| title_sort | clinical and capillaroscopic modifications of the psoriatic plaque during therapy observations with oral acitretin |
| url | http://dx.doi.org/10.1155/2013/781942 |
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