Bradykinin B1 receptor signaling triggers complement activation on endothelial cells

Bradykinin B1 receptor signaling triggers complement activation on endothelial cells

IntroductionThe complement and kallikrein-kinin systems (KKS) are both activated during vascular inflammation, and there are many known interactions between the two systems. This study investigated if KKS activation induced complement activation on endothelial cells, and if activation was dependent...

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Bibliographic Details
Main Authors: Ingrid Lopatko Fagerström, Alexandra Gerogianni, Markus Wendler, Ida Arvidsson, Ashmita Tontanahal, Ann-Charlotte Kristoffersson, Fatimunnisa Qadri, Michael Bader, Diana Karpman
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Immunology
Subjects:
bradykinin
complement
kallikrein–kinin system
glomerular endothelial cells
kidney
mice
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1527065/full
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