High expression of nucleobindin 2 is associated with poor prognosis in gastric cancer
Nucleobindin 2 has been reported that its high expression is associated with poor outcome and promotes cell migration and lymph node metastasis in breast cancer, colon cancer, and prostate cancer. However, we aimed to investigate the nucleobindin 2 expression in gastric cancer tissues and adjacent n...
Saved in:
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2017-07-01
|
| Series: | Tumor Biology |
| Online Access: | https://doi.org/10.1177/1010428317703817 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849396247956291584 |
|---|---|
| author | Bolag Altan Kyoichi Kaira Shuichi Okada Tsugumichi Saito Eijiro Yamada Halin Bao Pinjie Bao Kengo Takahashi Takehiko Yokobori Oyama Tetsunari Masahiko Nishiyama Masanobu Yamada |
| author_facet | Bolag Altan Kyoichi Kaira Shuichi Okada Tsugumichi Saito Eijiro Yamada Halin Bao Pinjie Bao Kengo Takahashi Takehiko Yokobori Oyama Tetsunari Masahiko Nishiyama Masanobu Yamada |
| author_sort | Bolag Altan |
| collection | DOAJ |
| description | Nucleobindin 2 has been reported that its high expression is associated with poor outcome and promotes cell migration and lymph node metastasis in breast cancer, colon cancer, and prostate cancer. However, we aimed to investigate the nucleobindin 2 expression in gastric cancer tissues and adjacent non-tumor tissues and its potential relevance to clinicopathological factors and prognosis using immunohistochemical analysis. In our study, nucleobindin 2 level in gastric cancer tissues was higher than in non-tumor tissues. A high expression of nucleobindin 2 is significantly associated with tumor depth, lymph node metastasis, lymphatic invasion, venous invasion, and clinical stage. Furthermore, the expression level of nucleobindin 2 protein was independent predictor of progression-free survival. In summary, nucleobindin 2 might play a crucial role in gastric cancer development and could serve as an independent predictor of prognosis of gastric cancer patients. |
| format | Article |
| id | doaj-art-d968dd3c09ab46958e7e9995f8de448d |
| institution | Kabale University |
| issn | 1423-0380 |
| language | English |
| publishDate | 2017-07-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Tumor Biology |
| spelling | doaj-art-d968dd3c09ab46958e7e9995f8de448d2025-08-20T03:39:22ZengSAGE PublishingTumor Biology1423-03802017-07-013910.1177/1010428317703817High expression of nucleobindin 2 is associated with poor prognosis in gastric cancerBolag Altan0Kyoichi Kaira1Shuichi Okada2Tsugumichi Saito3Eijiro Yamada4Halin Bao5Pinjie Bao6Kengo Takahashi7Takehiko Yokobori8Oyama Tetsunari9Masahiko Nishiyama10Masanobu Yamada11Department of Oncology Clinical Development, Graduate School of Medicine, Gunma University, Maebashi, JapanDepartment of Oncology Clinical Development, Graduate School of Medicine, Gunma University, Maebashi, JapanDepartment of Medicine and Molecular Science, Graduate School of Medicine, Gunma University, Maebashi, JapanDepartment of Medicine and Molecular Science, Graduate School of Medicine, Gunma University, Maebashi, JapanDepartment of Medicine and Molecular Science, Graduate School of Medicine, Gunma University, Maebashi, JapanDepartment of General Surgical Science, Graduate School of Medicine, Gunma University, Maebashi, JapanDepartment of General Surgical Science, Graduate School of Medicine, Gunma University, Maebashi, JapanDepartment of Thoracic and Visceral Organ Surgery, Graduate School of Medicine, Gunma University, Maebashi, JapanResearch Program for Omics-based Medical Science, Division of Integrated Oncology Research, Gunma University Initiative for Advanced Research, Maebashi, JapanDepartment of Diagnostic Pathology, Graduate School of Medicine, Gunma University, Maebashi, JapanDepartment of Molecular Pharmacology and Oncology, Graduate School of Medicine, Gunma University, Maebashi, JapanDepartment of Medicine and Molecular Science, Graduate School of Medicine, Gunma University, Maebashi, JapanNucleobindin 2 has been reported that its high expression is associated with poor outcome and promotes cell migration and lymph node metastasis in breast cancer, colon cancer, and prostate cancer. However, we aimed to investigate the nucleobindin 2 expression in gastric cancer tissues and adjacent non-tumor tissues and its potential relevance to clinicopathological factors and prognosis using immunohistochemical analysis. In our study, nucleobindin 2 level in gastric cancer tissues was higher than in non-tumor tissues. A high expression of nucleobindin 2 is significantly associated with tumor depth, lymph node metastasis, lymphatic invasion, venous invasion, and clinical stage. Furthermore, the expression level of nucleobindin 2 protein was independent predictor of progression-free survival. In summary, nucleobindin 2 might play a crucial role in gastric cancer development and could serve as an independent predictor of prognosis of gastric cancer patients.https://doi.org/10.1177/1010428317703817 |
| spellingShingle | Bolag Altan Kyoichi Kaira Shuichi Okada Tsugumichi Saito Eijiro Yamada Halin Bao Pinjie Bao Kengo Takahashi Takehiko Yokobori Oyama Tetsunari Masahiko Nishiyama Masanobu Yamada High expression of nucleobindin 2 is associated with poor prognosis in gastric cancer Tumor Biology |
| title | High expression of nucleobindin 2 is associated with poor prognosis in gastric cancer |
| title_full | High expression of nucleobindin 2 is associated with poor prognosis in gastric cancer |
| title_fullStr | High expression of nucleobindin 2 is associated with poor prognosis in gastric cancer |
| title_full_unstemmed | High expression of nucleobindin 2 is associated with poor prognosis in gastric cancer |
| title_short | High expression of nucleobindin 2 is associated with poor prognosis in gastric cancer |
| title_sort | high expression of nucleobindin 2 is associated with poor prognosis in gastric cancer |
| url | https://doi.org/10.1177/1010428317703817 |
| work_keys_str_mv | AT bolagaltan highexpressionofnucleobindin2isassociatedwithpoorprognosisingastriccancer AT kyoichikaira highexpressionofnucleobindin2isassociatedwithpoorprognosisingastriccancer AT shuichiokada highexpressionofnucleobindin2isassociatedwithpoorprognosisingastriccancer AT tsugumichisaito highexpressionofnucleobindin2isassociatedwithpoorprognosisingastriccancer AT eijiroyamada highexpressionofnucleobindin2isassociatedwithpoorprognosisingastriccancer AT halinbao highexpressionofnucleobindin2isassociatedwithpoorprognosisingastriccancer AT pinjiebao highexpressionofnucleobindin2isassociatedwithpoorprognosisingastriccancer AT kengotakahashi highexpressionofnucleobindin2isassociatedwithpoorprognosisingastriccancer AT takehikoyokobori highexpressionofnucleobindin2isassociatedwithpoorprognosisingastriccancer AT oyamatetsunari highexpressionofnucleobindin2isassociatedwithpoorprognosisingastriccancer AT masahikonishiyama highexpressionofnucleobindin2isassociatedwithpoorprognosisingastriccancer AT masanobuyamada highexpressionofnucleobindin2isassociatedwithpoorprognosisingastriccancer |