Novel oral compound Z526 mitigates cancer-associated cachexia via intervening NF-κB signaling and oxidative stress

Novel oral compound Z526 mitigates cancer-associated cachexia via intervening NF-κB signaling and oxidative stress

Cancer-associated cachexia (CAC) is a severe metabolic disorder syndrome mainly characterized by muscle and fat loss, which accounts for one-third of cancer-related deaths. No effective therapeutic approach that could fully reverse CAC is available. NF-κB signaling and oxidative stress play vital ro...

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Bibliographic Details
Main Authors: Xiaofan Gu, Shanshan Lu, Shuang Xu, Yiwei Li, Meng Fan, Guangyu Lin, Yiyuan Liu, Yun Zhao, Weili Zhao, Xuan Liu, Xiaochun Dong, Xiongwen Zhang
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2025-03-01
Series:Genes and Diseases
Subjects:
Cancer-associated cachexia
Fat lipolysis
Muscle atrophy
NF-κB signaling
Oxidative stress
Z526
Online Access:http://www.sciencedirect.com/science/article/pii/S2352304224000898
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