Network Pharmacology Suggests Mechanisms for Therapeutic Effects of Caulis Sinomenii on Avian Gout
Avian gout (AG) is detrimental to the survival and production performance of poultry and effective drugs are lacking. Caulis sinomenii has shown clinical efficacy against arthritis and may have potential value in AG prevention and treatment. In the present study, the components and targets of C. sin...
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| Format: | Article |
| Language: | English |
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Japan Poultry Science Association
2025-01-01
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| Series: | The Journal of Poultry Science |
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| Online Access: | https://www.jstage.jst.go.jp/article/jpsa/62/0/62_2025002/_html/-char/en |
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| author | Guanyang Li Junfei Xu Huanhuan Li Wenxin Yan Fengting Chen Anwen Yuan Juzuo Zhang |
| author_facet | Guanyang Li Junfei Xu Huanhuan Li Wenxin Yan Fengting Chen Anwen Yuan Juzuo Zhang |
| author_sort | Guanyang Li |
| collection | DOAJ |
| description | Avian gout (AG) is detrimental to the survival and production performance of poultry and effective drugs are lacking. Caulis sinomenii has shown clinical efficacy against arthritis and may have potential value in AG prevention and treatment. In the present study, the components and targets of C. sinomenii and AG-related targets were identified using relevant databases. The common targets, target interactions, and signaling pathways involved in the prevention and treatment of AG by C. sinomenii were determined using software to explore the potential mechanisms of action. Sixteen components of C. sinomenii, eight of which were active ingredients with 351 targets and 2993 AG-related targets, were identified using several databases. A total of 156 common targets were associated with 202 biological processes and 34 pathways. Toll-like receptor 4 (TLR4) and prostaglandin endoperoxide synthase 2 were core targets. These targets may exert therapeutic effects on AG through four pathways: the nucleotide-binding oligomerization domain (NOD)-like receptor, mammalian target of rapamycin, TLR, and mitogen-activated protein kinase signaling pathways. In summary, C. sinomenii has potential therapeutic efficacy against AG through multicomponent, multi-target, and multi-pathway mechanisms. |
| format | Article |
| id | doaj-art-d966134eae5b461a99c21a09c806057f |
| institution | Kabale University |
| issn | 1346-7395 1349-0486 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Japan Poultry Science Association |
| record_format | Article |
| series | The Journal of Poultry Science |
| spelling | doaj-art-d966134eae5b461a99c21a09c806057f2025-01-08T05:13:22ZengJapan Poultry Science AssociationThe Journal of Poultry Science1346-73951349-04862025-01-0162010.2141/jpsa.2025002jpsaNetwork Pharmacology Suggests Mechanisms for Therapeutic Effects of Caulis Sinomenii on Avian GoutGuanyang Li0Junfei Xu1Huanhuan Li2Wenxin Yan3Fengting Chen4Anwen Yuan5Juzuo Zhang6Department of Clinic Veterinary Medicine, College of Veterinary Medicine, Hunan Agricultural University, Changsha 410128, China.College of Biological and Food Engineering/Key Laboratory of Research and Utilization of Ethnomedicinal Plant Resources of Hunan Province/Hunan Provincial Higher Education Key Laboratory of Intensive Processing Research on Mountain Ecological Food, Huaihua University, Huaihua 418000, China.College of Biological and Food Engineering/Key Laboratory of Research and Utilization of Ethnomedicinal Plant Resources of Hunan Province/Hunan Provincial Higher Education Key Laboratory of Intensive Processing Research on Mountain Ecological Food, Huaihua University, Huaihua 418000, China.College of Biological and Food Engineering/Key Laboratory of Research and Utilization of Ethnomedicinal Plant Resources of Hunan Province/Hunan Provincial Higher Education Key Laboratory of Intensive Processing Research on Mountain Ecological Food, Huaihua University, Huaihua 418000, China.College of Biological and Food Engineering/Key Laboratory of Research and Utilization of Ethnomedicinal Plant Resources of Hunan Province/Hunan Provincial Higher Education Key Laboratory of Intensive Processing Research on Mountain Ecological Food, Huaihua University, Huaihua 418000, China.Department of Clinic Veterinary Medicine, College of Veterinary Medicine, Hunan Agricultural University, Changsha 410128, China.Department of Clinic Veterinary Medicine, College of Veterinary Medicine, Hunan Agricultural University, Changsha 410128, China.Avian gout (AG) is detrimental to the survival and production performance of poultry and effective drugs are lacking. Caulis sinomenii has shown clinical efficacy against arthritis and may have potential value in AG prevention and treatment. In the present study, the components and targets of C. sinomenii and AG-related targets were identified using relevant databases. The common targets, target interactions, and signaling pathways involved in the prevention and treatment of AG by C. sinomenii were determined using software to explore the potential mechanisms of action. Sixteen components of C. sinomenii, eight of which were active ingredients with 351 targets and 2993 AG-related targets, were identified using several databases. A total of 156 common targets were associated with 202 biological processes and 34 pathways. Toll-like receptor 4 (TLR4) and prostaglandin endoperoxide synthase 2 were core targets. These targets may exert therapeutic effects on AG through four pathways: the nucleotide-binding oligomerization domain (NOD)-like receptor, mammalian target of rapamycin, TLR, and mitogen-activated protein kinase signaling pathways. In summary, C. sinomenii has potential therapeutic efficacy against AG through multicomponent, multi-target, and multi-pathway mechanisms.https://www.jstage.jst.go.jp/article/jpsa/62/0/62_2025002/_html/-char/enavian goutcaulis sinomeniimolecular dockingnetwork pharmacology |
| spellingShingle | Guanyang Li Junfei Xu Huanhuan Li Wenxin Yan Fengting Chen Anwen Yuan Juzuo Zhang Network Pharmacology Suggests Mechanisms for Therapeutic Effects of Caulis Sinomenii on Avian Gout The Journal of Poultry Science avian gout caulis sinomenii molecular docking network pharmacology |
| title | Network Pharmacology Suggests Mechanisms for Therapeutic Effects of Caulis Sinomenii on Avian Gout |
| title_full | Network Pharmacology Suggests Mechanisms for Therapeutic Effects of Caulis Sinomenii on Avian Gout |
| title_fullStr | Network Pharmacology Suggests Mechanisms for Therapeutic Effects of Caulis Sinomenii on Avian Gout |
| title_full_unstemmed | Network Pharmacology Suggests Mechanisms for Therapeutic Effects of Caulis Sinomenii on Avian Gout |
| title_short | Network Pharmacology Suggests Mechanisms for Therapeutic Effects of Caulis Sinomenii on Avian Gout |
| title_sort | network pharmacology suggests mechanisms for therapeutic effects of caulis sinomenii on avian gout |
| topic | avian gout caulis sinomenii molecular docking network pharmacology |
| url | https://www.jstage.jst.go.jp/article/jpsa/62/0/62_2025002/_html/-char/en |
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