Protective effect of Panax ginseng extract on cisplatin-induced AKI via downregulating cell death associated genes
Abstract This study is designed to assess the effect of root extract of P. ginseng on kidney tissue injury attributed to cisplatin and its molecular mechanism involved in this process in the AKI rat model. Twenty-four male Wistar rats were randomly allocated into 4 experimental groups including: the...
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Nature Portfolio
2025-01-01
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| Online Access: | https://doi.org/10.1038/s41598-025-87447-0 |
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| author | Reza Alipanah-Moghadam Vahideh Aghamohammadi Sina Seifi Hedieh Esmaeili Somaieh Noroozzadeh Farhad Jeddi Ramin Salimnejad Ali Nemati |
| author_facet | Reza Alipanah-Moghadam Vahideh Aghamohammadi Sina Seifi Hedieh Esmaeili Somaieh Noroozzadeh Farhad Jeddi Ramin Salimnejad Ali Nemati |
| author_sort | Reza Alipanah-Moghadam |
| collection | DOAJ |
| description | Abstract This study is designed to assess the effect of root extract of P. ginseng on kidney tissue injury attributed to cisplatin and its molecular mechanism involved in this process in the AKI rat model. Twenty-four male Wistar rats were randomly allocated into 4 experimental groups including: the control group, the cisplatin group, the extract 100 mg/kg group, and the extract 200 mg/kg group. The duration of the investigation was 7 days, and all rats except the control group received a single dose of 10 mg/kg cisplatin on the 4th day. Our findings exhibited a significant reduction in blood concentration of creatinine in extract groups compared to the cisplatin group. In the cisplatin group, severe renal histopathological alterations were observed compared to the control group. In extract groups, significantly less tissue damage was observed than in the cisplatin group. Ginseng extract 200 showed minimal tissue damage as compared to extract 100. The expression of p21, p27, p53, TIMP2, IGFBP7, and NF-κB decreased significantly in extract groups compared to the cisplatin group. Our findings displayed amelioration of cisplatin-induced AKI and dose-dependent decrease of the NF-κB gene expression and cell death-inducing genes by administration of P. ginseng extract. |
| format | Article |
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| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
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| spelling | doaj-art-d9609e6b27df4f82a4f495f3ff365f2a2025-01-26T12:28:15ZengNature PortfolioScientific Reports2045-23222025-01-011511910.1038/s41598-025-87447-0Protective effect of Panax ginseng extract on cisplatin-induced AKI via downregulating cell death associated genesReza Alipanah-Moghadam0Vahideh Aghamohammadi1Sina Seifi2Hedieh Esmaeili3Somaieh Noroozzadeh4Farhad Jeddi5Ramin Salimnejad6Ali Nemati7Department of Clinical Biochemistry, School of Medicine, Ardabil University of Medical SciencesDepartment of Nutrition, Khalkhal University of Medical SciencesDepartment of Clinical Biochemistry, School of Medicine, Ardabil University of Medical SciencesDepartment of Clinical Biochemistry, School of Medicine, Ardabil University of Medical SciencesDepartment of Clinical Biochemistry, School of Medicine, Ardabil University of Medical SciencesDepartment of Genetics and Pathology, School of Medicine, Ardabil University of Medical SciencesDepartment of Anatomical Sciences, School of Medicine, Ardabil University of Medical SciencesDepartment of Clinical Biochemistry, School of Medicine, Ardabil University of Medical SciencesAbstract This study is designed to assess the effect of root extract of P. ginseng on kidney tissue injury attributed to cisplatin and its molecular mechanism involved in this process in the AKI rat model. Twenty-four male Wistar rats were randomly allocated into 4 experimental groups including: the control group, the cisplatin group, the extract 100 mg/kg group, and the extract 200 mg/kg group. The duration of the investigation was 7 days, and all rats except the control group received a single dose of 10 mg/kg cisplatin on the 4th day. Our findings exhibited a significant reduction in blood concentration of creatinine in extract groups compared to the cisplatin group. In the cisplatin group, severe renal histopathological alterations were observed compared to the control group. In extract groups, significantly less tissue damage was observed than in the cisplatin group. Ginseng extract 200 showed minimal tissue damage as compared to extract 100. The expression of p21, p27, p53, TIMP2, IGFBP7, and NF-κB decreased significantly in extract groups compared to the cisplatin group. Our findings displayed amelioration of cisplatin-induced AKI and dose-dependent decrease of the NF-κB gene expression and cell death-inducing genes by administration of P. ginseng extract.https://doi.org/10.1038/s41598-025-87447-0Acute kidney injuryGinsengCisplatinCell death genes |
| spellingShingle | Reza Alipanah-Moghadam Vahideh Aghamohammadi Sina Seifi Hedieh Esmaeili Somaieh Noroozzadeh Farhad Jeddi Ramin Salimnejad Ali Nemati Protective effect of Panax ginseng extract on cisplatin-induced AKI via downregulating cell death associated genes Scientific Reports Acute kidney injury Ginseng Cisplatin Cell death genes |
| title | Protective effect of Panax ginseng extract on cisplatin-induced AKI via downregulating cell death associated genes |
| title_full | Protective effect of Panax ginseng extract on cisplatin-induced AKI via downregulating cell death associated genes |
| title_fullStr | Protective effect of Panax ginseng extract on cisplatin-induced AKI via downregulating cell death associated genes |
| title_full_unstemmed | Protective effect of Panax ginseng extract on cisplatin-induced AKI via downregulating cell death associated genes |
| title_short | Protective effect of Panax ginseng extract on cisplatin-induced AKI via downregulating cell death associated genes |
| title_sort | protective effect of panax ginseng extract on cisplatin induced aki via downregulating cell death associated genes |
| topic | Acute kidney injury Ginseng Cisplatin Cell death genes |
| url | https://doi.org/10.1038/s41598-025-87447-0 |
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