The effectiveness of split tablet dosing versus alternate-day dosing of warfarin: a randomized control trial
Abstract Due to large dosage variation, a variety of warfarin prescription regimens are utilized for specific doses such as tablet splitting, or pill strength alternating. The clinical comparison between the two is lacking. We hypothesize that both approaches result in different times in therapeutic...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-12-01
|
| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-03606-z |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849432591731523584 |
|---|---|
| author | Chanyapat Kaewsaengeak Usanee Pienputtarapong Teerapong Tocharoenchok |
| author_facet | Chanyapat Kaewsaengeak Usanee Pienputtarapong Teerapong Tocharoenchok |
| author_sort | Chanyapat Kaewsaengeak |
| collection | DOAJ |
| description | Abstract Due to large dosage variation, a variety of warfarin prescription regimens are utilized for specific doses such as tablet splitting, or pill strength alternating. The clinical comparison between the two is lacking. We hypothesize that both approaches result in different times in therapeutic range. We randomized patients with specific warfarin dosage and stable INR for 6 months or longer to receive the whole tablet, alternate-day dosing or the split tablet, same daily-dosing regimen without initial dose change and followed them every 6 weeks for 6 months. The primary outcome was a time in therapeutic range of 2.0–3.0. The secondary outcomes included dosage, compliance, INR, anticoagulant-related events. A total of 66 patients were enrolled, 32 randomly assigned to the split tablet regimen (group S) and 34 to the alternate-day regimen (group A) with two withdrawers. The mean age was 58.6 ± 8.5 years. All baseline characteristics of both groups were similar. The average time in therapeutic range was 72.8 ± 25.4% in group S and 74.9 ± 22.0% in group A (p = 0.72). There were no significant differences in warfarin dosage, compliance, INR and, complications between the two groups. Both warfarin prescription methods, the split tablet and the alternate-day had comparable time in the therapeutic range. |
| format | Article |
| id | doaj-art-d95f0f0cef974edf9f7e8515bb3ffa0a |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2021-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-d95f0f0cef974edf9f7e8515bb3ffa0a2025-08-20T03:27:18ZengNature PortfolioScientific Reports2045-23222021-12-011111610.1038/s41598-021-03606-zThe effectiveness of split tablet dosing versus alternate-day dosing of warfarin: a randomized control trialChanyapat Kaewsaengeak0Usanee Pienputtarapong1Teerapong Tocharoenchok2Department of Surgery, Police General HospitalAmbulatory Care Unit, Pharmacy Department, Faculty of Medicine Siriraj Hospital, Mahidol UniversityDivision of Cardiothoracic Surgery, Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol UniversityAbstract Due to large dosage variation, a variety of warfarin prescription regimens are utilized for specific doses such as tablet splitting, or pill strength alternating. The clinical comparison between the two is lacking. We hypothesize that both approaches result in different times in therapeutic range. We randomized patients with specific warfarin dosage and stable INR for 6 months or longer to receive the whole tablet, alternate-day dosing or the split tablet, same daily-dosing regimen without initial dose change and followed them every 6 weeks for 6 months. The primary outcome was a time in therapeutic range of 2.0–3.0. The secondary outcomes included dosage, compliance, INR, anticoagulant-related events. A total of 66 patients were enrolled, 32 randomly assigned to the split tablet regimen (group S) and 34 to the alternate-day regimen (group A) with two withdrawers. The mean age was 58.6 ± 8.5 years. All baseline characteristics of both groups were similar. The average time in therapeutic range was 72.8 ± 25.4% in group S and 74.9 ± 22.0% in group A (p = 0.72). There were no significant differences in warfarin dosage, compliance, INR and, complications between the two groups. Both warfarin prescription methods, the split tablet and the alternate-day had comparable time in the therapeutic range.https://doi.org/10.1038/s41598-021-03606-z |
| spellingShingle | Chanyapat Kaewsaengeak Usanee Pienputtarapong Teerapong Tocharoenchok The effectiveness of split tablet dosing versus alternate-day dosing of warfarin: a randomized control trial Scientific Reports |
| title | The effectiveness of split tablet dosing versus alternate-day dosing of warfarin: a randomized control trial |
| title_full | The effectiveness of split tablet dosing versus alternate-day dosing of warfarin: a randomized control trial |
| title_fullStr | The effectiveness of split tablet dosing versus alternate-day dosing of warfarin: a randomized control trial |
| title_full_unstemmed | The effectiveness of split tablet dosing versus alternate-day dosing of warfarin: a randomized control trial |
| title_short | The effectiveness of split tablet dosing versus alternate-day dosing of warfarin: a randomized control trial |
| title_sort | effectiveness of split tablet dosing versus alternate day dosing of warfarin a randomized control trial |
| url | https://doi.org/10.1038/s41598-021-03606-z |
| work_keys_str_mv | AT chanyapatkaewsaengeak theeffectivenessofsplittabletdosingversusalternatedaydosingofwarfarinarandomizedcontroltrial AT usaneepienputtarapong theeffectivenessofsplittabletdosingversusalternatedaydosingofwarfarinarandomizedcontroltrial AT teerapongtocharoenchok theeffectivenessofsplittabletdosingversusalternatedaydosingofwarfarinarandomizedcontroltrial AT chanyapatkaewsaengeak effectivenessofsplittabletdosingversusalternatedaydosingofwarfarinarandomizedcontroltrial AT usaneepienputtarapong effectivenessofsplittabletdosingversusalternatedaydosingofwarfarinarandomizedcontroltrial AT teerapongtocharoenchok effectivenessofsplittabletdosingversusalternatedaydosingofwarfarinarandomizedcontroltrial |