The Role of Microelements of Lumbar Disc Degeneration in Patients Undergoing Lumbar Spine Surgery
Background: Lumbar disc degeneration (LDD) is a common musculoskeletal disorder that frequently causes low back pain (LBP). In addition to the discomfort of lower back pain, it can accompany pain in one or both legs. The lumbar spine and sacrum, consisting of five vertebrae and one bone, determine...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
College of Medicine University of Baghdad
2024-12-01
|
| Series: | مجلة كلية الطب |
| Subjects: | |
| Online Access: | https://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/2388 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832594723108290560 |
|---|---|
| author | Sadiq R. Karkush Manal K. Rasheed Ali T. Abdul Wahid Ahmed R. Majeed |
| author_facet | Sadiq R. Karkush Manal K. Rasheed Ali T. Abdul Wahid Ahmed R. Majeed |
| author_sort | Sadiq R. Karkush |
| collection | DOAJ |
| description |
Background: Lumbar disc degeneration (LDD) is a common musculoskeletal disorder that frequently causes low back pain (LBP). In addition to the discomfort of lower back pain, it can accompany pain in one or both legs. The lumbar spine and sacrum, consisting of five vertebrae and one bone, determine the spine's balance. Microelements are essential in bone metabolism and are associated with the prevention of osteoporosis and the alleviation of musculoskeletal pain.
Objectives: To examine the correlation between lumbar spinal surgery and the concentrations of microelements, namely zinc and copper.
Methods: A case-control study was conducted in Ghazi Al-Hariri Hospital in Baghdad, Iraq, during the period from October 2023 to January 2024. The study included 120 participants ranging in age from 18 to 70 years. Sixty participants underwent lumbar spine surgery and were diagnosed using X-rays or MRI scans. The other 60 were healthy controls. The zinc (Zn) and copper (Cu) levels in the blood were determined using an atomic absorption spectrometer. The body mass index (BMI) was determined using the formula: BMIg/m2 = weight/height2.
Results: The patients had a lower mean zinc level (57.3 ± 14.56 Mmol/L) and a higher mean copper level (106.6 ± 39.41 Mmol/L) in comparison to healthy controls (96.4 ± 17.38 Mmol/L) and (61.0 ± 9.53 Mmol/L), respectively There was a weak relationship and a significant correlation between copper and zinc (r = -0.2). A very strong relationship and a significant correlation between copper and Cu / Zn ratio (r = 0.85) while zinc had a significant very strong correlation relationship with Cu / Zn ratio (r = -0.7) in patients.
Conclusion: The present study underscores the noteworthy association between microelements (Cu, Zn) and degenerative lumbar discs, underscoring the significance of pre-operative evaluation in achieving the best possible surgical results. The study has demonstrated the utility of measuring serum zinc level and copper level, especially their link with lumbar disc degeneration (LDD) markers of patients undergoing lumbar spinal surgery.
|
| format | Article |
| id | doaj-art-d95eb6db5a874bb9a6cb13a1138b3546 |
| institution | Kabale University |
| issn | 0041-9419 2410-8057 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | College of Medicine University of Baghdad |
| record_format | Article |
| series | مجلة كلية الطب |
| spelling | doaj-art-d95eb6db5a874bb9a6cb13a1138b35462025-01-19T12:24:09ZengCollege of Medicine University of Baghdadمجلة كلية الطب0041-94192410-80572024-12-0166410.32007/jfacmedbaghdad.6642388The Role of Microelements of Lumbar Disc Degeneration in Patients Undergoing Lumbar Spine SurgerySadiq R. Karkush0https://orcid.org/0009-0004-8654-4371Manal K. Rasheed1https://orcid.org/0000-0003-3324-0425Ali T. Abdul Wahid2https://orcid.org/0009-0009-3707-2140Ahmed R. Majeed3https://orcid.org/0009-0006-8543-612XDepartment of Biochemistry, College of Medicine, the University of Baghdad, Iraq.Department of Biochemistry - College of Medicine - University of BaghdadDepartment of Surgery, College of Medicine, University of Baghdad, Iraq.University Hospital Sharjah, Sharjah, UAE. Background: Lumbar disc degeneration (LDD) is a common musculoskeletal disorder that frequently causes low back pain (LBP). In addition to the discomfort of lower back pain, it can accompany pain in one or both legs. The lumbar spine and sacrum, consisting of five vertebrae and one bone, determine the spine's balance. Microelements are essential in bone metabolism and are associated with the prevention of osteoporosis and the alleviation of musculoskeletal pain. Objectives: To examine the correlation between lumbar spinal surgery and the concentrations of microelements, namely zinc and copper. Methods: A case-control study was conducted in Ghazi Al-Hariri Hospital in Baghdad, Iraq, during the period from October 2023 to January 2024. The study included 120 participants ranging in age from 18 to 70 years. Sixty participants underwent lumbar spine surgery and were diagnosed using X-rays or MRI scans. The other 60 were healthy controls. The zinc (Zn) and copper (Cu) levels in the blood were determined using an atomic absorption spectrometer. The body mass index (BMI) was determined using the formula: BMIg/m2 = weight/height2. Results: The patients had a lower mean zinc level (57.3 ± 14.56 Mmol/L) and a higher mean copper level (106.6 ± 39.41 Mmol/L) in comparison to healthy controls (96.4 ± 17.38 Mmol/L) and (61.0 ± 9.53 Mmol/L), respectively There was a weak relationship and a significant correlation between copper and zinc (r = -0.2). A very strong relationship and a significant correlation between copper and Cu / Zn ratio (r = 0.85) while zinc had a significant very strong correlation relationship with Cu / Zn ratio (r = -0.7) in patients. Conclusion: The present study underscores the noteworthy association between microelements (Cu, Zn) and degenerative lumbar discs, underscoring the significance of pre-operative evaluation in achieving the best possible surgical results. The study has demonstrated the utility of measuring serum zinc level and copper level, especially their link with lumbar disc degeneration (LDD) markers of patients undergoing lumbar spinal surgery. https://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/2388CopperDegenerationLower back painLumbar DiscSpinal surgeryZinc |
| spellingShingle | Sadiq R. Karkush Manal K. Rasheed Ali T. Abdul Wahid Ahmed R. Majeed The Role of Microelements of Lumbar Disc Degeneration in Patients Undergoing Lumbar Spine Surgery مجلة كلية الطب Copper Degeneration Lower back pain Lumbar Disc Spinal surgery Zinc |
| title | The Role of Microelements of Lumbar Disc Degeneration in Patients Undergoing Lumbar Spine Surgery |
| title_full | The Role of Microelements of Lumbar Disc Degeneration in Patients Undergoing Lumbar Spine Surgery |
| title_fullStr | The Role of Microelements of Lumbar Disc Degeneration in Patients Undergoing Lumbar Spine Surgery |
| title_full_unstemmed | The Role of Microelements of Lumbar Disc Degeneration in Patients Undergoing Lumbar Spine Surgery |
| title_short | The Role of Microelements of Lumbar Disc Degeneration in Patients Undergoing Lumbar Spine Surgery |
| title_sort | role of microelements of lumbar disc degeneration in patients undergoing lumbar spine surgery |
| topic | Copper Degeneration Lower back pain Lumbar Disc Spinal surgery Zinc |
| url | https://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/2388 |
| work_keys_str_mv | AT sadiqrkarkush theroleofmicroelementsoflumbardiscdegenerationinpatientsundergoinglumbarspinesurgery AT manalkrasheed theroleofmicroelementsoflumbardiscdegenerationinpatientsundergoinglumbarspinesurgery AT alitabdulwahid theroleofmicroelementsoflumbardiscdegenerationinpatientsundergoinglumbarspinesurgery AT ahmedrmajeed theroleofmicroelementsoflumbardiscdegenerationinpatientsundergoinglumbarspinesurgery AT sadiqrkarkush roleofmicroelementsoflumbardiscdegenerationinpatientsundergoinglumbarspinesurgery AT manalkrasheed roleofmicroelementsoflumbardiscdegenerationinpatientsundergoinglumbarspinesurgery AT alitabdulwahid roleofmicroelementsoflumbardiscdegenerationinpatientsundergoinglumbarspinesurgery AT ahmedrmajeed roleofmicroelementsoflumbardiscdegenerationinpatientsundergoinglumbarspinesurgery |