Diagnosis of human envenoming by terrestrial venomous animals: Routine, advances, and perspectives
Despite the development of new and advanced diagnostic approaches, monitoring the clinical evolution of accidents caused by venomous animals is still a challenge for science. In this review, we present the state of the art of laboratory tests that are routinely used for the diagnosis and monitoring...
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| Language: | English |
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Elsevier
2024-12-01
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| Series: | Toxicon: X |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590171024000286 |
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| author | Joeliton S. Cavalcante Sabrina Santana Toledo Arruda Pedro Marques Riciopo Manuela Pucca Rui Seabra Ferreira Junior |
| author_facet | Joeliton S. Cavalcante Sabrina Santana Toledo Arruda Pedro Marques Riciopo Manuela Pucca Rui Seabra Ferreira Junior |
| author_sort | Joeliton S. Cavalcante |
| collection | DOAJ |
| description | Despite the development of new and advanced diagnostic approaches, monitoring the clinical evolution of accidents caused by venomous animals is still a challenge for science. In this review, we present the state of the art of laboratory tests that are routinely used for the diagnosis and monitoring of envenomings by venomous animals, as well as the use of new tools for more accurate and specific diagnoses. While a comprehensive range of tools is outlined, comprising hematological, biochemical, immunoassays, and diagnostic imaging tools, it is important to acknowledge their limitations in predicting the onset of clinical complications, since they provide an overview of organic damage after its development. Thus, the need for discovery, validation, and use of biomarkers that have greater predictive power, sensitivity and specificity is evident. This will help in the diagnosis, monitoring, and treatment of patients envenomated by venomous animals, consequently reducing the global burden of morbidity and mortality. |
| format | Article |
| id | doaj-art-d95dce6dcbbd4673aee3ce83f5b7121b |
| institution | OA Journals |
| issn | 2590-1710 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Toxicon: X |
| spelling | doaj-art-d95dce6dcbbd4673aee3ce83f5b7121b2025-08-20T01:59:31ZengElsevierToxicon: X2590-17102024-12-012410021110.1016/j.toxcx.2024.100211Diagnosis of human envenoming by terrestrial venomous animals: Routine, advances, and perspectivesJoeliton S. Cavalcante0Sabrina Santana Toledo Arruda1Pedro Marques Riciopo2Manuela Pucca3Rui Seabra Ferreira Junior4Graduate Program in Tropical Diseases, Botucatu Medical School (FMB), São Paulo State University (UNESP—Univ Estadual Paulista), Botucatu, 18618-687, São Paulo, BrazilDepartment of Bioprocess and Biotechnology, School of Agriculture, Agronomic Sciences School, São Paulo State University (UNESP—Univ Estadual Paulista), Botucatu, 18618-687, São Paulo, BrazilDepartment of Bioprocess and Biotechnology, School of Agriculture, Agronomic Sciences School, São Paulo State University (UNESP—Univ Estadual Paulista), Botucatu, 18618-687, São Paulo, BrazilDepartment of Clinical Analysis, School of Pharmaceutical Sciences, São Paulo State University UNESP—Univ Estadual Paulista, Araraquara, 14800-903, BrazilGraduate Program in Tropical Diseases, Botucatu Medical School (FMB), São Paulo State University (UNESP—Univ Estadual Paulista), Botucatu, 18618-687, São Paulo, Brazil; Center for the Study of Venoms and Venomous Animals (CEVAP), São Paulo State University (UNESP—Univ Estadual Paulista), Botucatu, 18610-307, São Paulo, Brazil; Center for Translational Science and Development of Biopharmaceuticals FAPESP/CEVAP-UNESP, Botucatu, 18610-307, São Paulo, Brazil; Corresponding author. Graduate Program in Tropical Diseases, Botucatu Medical School (FMB), São Paulo State University (UNESP—Univ Estadual Paulista), Botucatu, 18618-687, São Paulo, Brazil.Despite the development of new and advanced diagnostic approaches, monitoring the clinical evolution of accidents caused by venomous animals is still a challenge for science. In this review, we present the state of the art of laboratory tests that are routinely used for the diagnosis and monitoring of envenomings by venomous animals, as well as the use of new tools for more accurate and specific diagnoses. While a comprehensive range of tools is outlined, comprising hematological, biochemical, immunoassays, and diagnostic imaging tools, it is important to acknowledge their limitations in predicting the onset of clinical complications, since they provide an overview of organic damage after its development. Thus, the need for discovery, validation, and use of biomarkers that have greater predictive power, sensitivity and specificity is evident. This will help in the diagnosis, monitoring, and treatment of patients envenomated by venomous animals, consequently reducing the global burden of morbidity and mortality.http://www.sciencedirect.com/science/article/pii/S2590171024000286BiomarkersClinical diagnosisDiagnosisEnvenomingsImaging toolsVenomous animals |
| spellingShingle | Joeliton S. Cavalcante Sabrina Santana Toledo Arruda Pedro Marques Riciopo Manuela Pucca Rui Seabra Ferreira Junior Diagnosis of human envenoming by terrestrial venomous animals: Routine, advances, and perspectives Toxicon: X Biomarkers Clinical diagnosis Diagnosis Envenomings Imaging tools Venomous animals |
| title | Diagnosis of human envenoming by terrestrial venomous animals: Routine, advances, and perspectives |
| title_full | Diagnosis of human envenoming by terrestrial venomous animals: Routine, advances, and perspectives |
| title_fullStr | Diagnosis of human envenoming by terrestrial venomous animals: Routine, advances, and perspectives |
| title_full_unstemmed | Diagnosis of human envenoming by terrestrial venomous animals: Routine, advances, and perspectives |
| title_short | Diagnosis of human envenoming by terrestrial venomous animals: Routine, advances, and perspectives |
| title_sort | diagnosis of human envenoming by terrestrial venomous animals routine advances and perspectives |
| topic | Biomarkers Clinical diagnosis Diagnosis Envenomings Imaging tools Venomous animals |
| url | http://www.sciencedirect.com/science/article/pii/S2590171024000286 |
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