Effects of anesthetics on development of gynecological cancer
Gynecological cancers remain a leading cause of cancer among female patients, and surgery continues to be the primary therapeutic approach. Anesthesia is an indispensable component of perioperative period. In recent years, the influence of anesthesia drugs on cancer has become one of the focuses of...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-04-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2025.1587548/full |
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| author | Yingxiang Cheng Yunzhi Wu Lingzhong Xu |
| author_facet | Yingxiang Cheng Yunzhi Wu Lingzhong Xu |
| author_sort | Yingxiang Cheng |
| collection | DOAJ |
| description | Gynecological cancers remain a leading cause of cancer among female patients, and surgery continues to be the primary therapeutic approach. Anesthesia is an indispensable component of perioperative period. In recent years, the influence of anesthesia drugs on cancer has become one of the focuses of anesthesiologists. Anesthetic drugs may influence cancer metabolic reprogramming and modulate immune function through the hypothalamic-pituitary-adrenal (HPA) axis and the sympathetic nervous system (SNS). Emerging evidence suggests that the choice of anesthetic agents could affect the prognosis of gynecological cancers. This review explores the relationship between anesthetic drugs and gynecological cancers (cervical cancer, ovarian cancer, and endometrial cancer), elucidating their effects on cancer prognosis through cellular pathways, metabolic regulation, and immune mechanisms. The findings aim to guide clinical decision-making and evaluate optimal perioperative anesthetic management strategies for gynecological cancer patients. |
| format | Article |
| id | doaj-art-d95b01694993452584864ffbcd6f5ef2 |
| institution | DOAJ |
| issn | 2296-634X |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj-art-d95b01694993452584864ffbcd6f5ef22025-08-20T03:10:25ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2025-04-011310.3389/fcell.2025.15875481587548Effects of anesthetics on development of gynecological cancerYingxiang Cheng0Yunzhi Wu1Lingzhong Xu2Department of Anesthesiology, Zhenjiang Fourth People’s Hospital, Zhenjiang, ChinaDepartment of Thoracic Surgery, Affiliated People’s Hospital of Jiangsu University, Zhenjiang, ChinaDepartment of Anesthesiology, Zhenjiang Fourth People’s Hospital, Zhenjiang, ChinaGynecological cancers remain a leading cause of cancer among female patients, and surgery continues to be the primary therapeutic approach. Anesthesia is an indispensable component of perioperative period. In recent years, the influence of anesthesia drugs on cancer has become one of the focuses of anesthesiologists. Anesthetic drugs may influence cancer metabolic reprogramming and modulate immune function through the hypothalamic-pituitary-adrenal (HPA) axis and the sympathetic nervous system (SNS). Emerging evidence suggests that the choice of anesthetic agents could affect the prognosis of gynecological cancers. This review explores the relationship between anesthetic drugs and gynecological cancers (cervical cancer, ovarian cancer, and endometrial cancer), elucidating their effects on cancer prognosis through cellular pathways, metabolic regulation, and immune mechanisms. The findings aim to guide clinical decision-making and evaluate optimal perioperative anesthetic management strategies for gynecological cancer patients.https://www.frontiersin.org/articles/10.3389/fcell.2025.1587548/fullcervical cancerovarian cancerendometrial cancerintravenous anestheticsvolatile anestheticslocal anesthetics |
| spellingShingle | Yingxiang Cheng Yunzhi Wu Lingzhong Xu Effects of anesthetics on development of gynecological cancer Frontiers in Cell and Developmental Biology cervical cancer ovarian cancer endometrial cancer intravenous anesthetics volatile anesthetics local anesthetics |
| title | Effects of anesthetics on development of gynecological cancer |
| title_full | Effects of anesthetics on development of gynecological cancer |
| title_fullStr | Effects of anesthetics on development of gynecological cancer |
| title_full_unstemmed | Effects of anesthetics on development of gynecological cancer |
| title_short | Effects of anesthetics on development of gynecological cancer |
| title_sort | effects of anesthetics on development of gynecological cancer |
| topic | cervical cancer ovarian cancer endometrial cancer intravenous anesthetics volatile anesthetics local anesthetics |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2025.1587548/full |
| work_keys_str_mv | AT yingxiangcheng effectsofanestheticsondevelopmentofgynecologicalcancer AT yunzhiwu effectsofanestheticsondevelopmentofgynecologicalcancer AT lingzhongxu effectsofanestheticsondevelopmentofgynecologicalcancer |