POLYMORPHISMS IN THE CYP-450 GENE AND MALARIA: A GENOTYPIC AND PHENOTYPIC RELATIONSHIP WITH THERAPEUTIC FAILURE

POLYMORPHISMS IN THE CYP-450 GENE AND MALARIA: A GENOTYPIC AND PHENOTYPIC RELATIONSHIP WITH THERAPEUTIC FAILURE

Introduction: Therapeutic failure in patients with malaria can occur due to various factors and polymorphisms in enzymes of the Cytochrome P450 (CYP450) family, responsible for around 90% of the metabolization of chloroquine and primaquine, can generate individuals who are low, intermediate or fast...

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Main Authors:	Marcelo Cerilo-Filho, Maria Naely Gomes Almeida, Marrara Pereira Sampaio, Dulce Jorge Viagem, Rayanne Iane Correa, Nathália Faria Reis, Andréa Regina de Souza Baptista, Ricardo Luiz Dantas Machado
Format:	Article
Language:	English
Published:	Elsevier 2024-11-01
Series:	Brazilian Journal of Infectious Diseases
Online Access:	http://www.sciencedirect.com/science/article/pii/S1413867024006834
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