Influence of insulin sensitivity on food cue evoked functional brain connectivity in children
Objective: Insulin resistance during childhood is a risk factor for developing type 2 diabetes and other health problems later in life. Studies in adults have shown that insulin resistance affects regional and network activity in the brain which are vital for behavior, including ingestion and metabo...
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Elsevier
2025-04-01
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1053811925001569 |
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| author | Lorenzo Semeia Ralf Veit Sixiu Zhao Shan Luo Brendan Angelo Andreas L. Birkenfeld Hubert Preissl Anny H. Xiang Stephanie Kullmann Kathleen A. Page |
| author_facet | Lorenzo Semeia Ralf Veit Sixiu Zhao Shan Luo Brendan Angelo Andreas L. Birkenfeld Hubert Preissl Anny H. Xiang Stephanie Kullmann Kathleen A. Page |
| author_sort | Lorenzo Semeia |
| collection | DOAJ |
| description | Objective: Insulin resistance during childhood is a risk factor for developing type 2 diabetes and other health problems later in life. Studies in adults have shown that insulin resistance affects regional and network activity in the brain which are vital for behavior, including ingestion and metabolic control. To date, no study has investigated how brain connections during exposure to food cues are association with peripheral insulin sensitivity in children. Methods: We included 53 children (36 girls) between the age of 7–11 years, who underwent an oral Glucose Tolerance Test (oGTT) to estimate peripheral insulin sensitivity (ISI). Brain responses were measured using functional magnetic resonance imaging (fMRI) before and after glucose ingestion. We compared food-cue task-based activity and functional connectivity (FC) between children with lower and higher ISI, adjusted for age and BMIz. Results: Independent of prandial state (i.e., glucose ingestion), children with lower ISI showed higher FC between the anterior insula and caudate and lower FC between the posterior insula and mid temporal cortex than children with higher ISI. Sex differences were found based on prandial state and peripheral insulin sensitivity in the insular FC. No differences were found on mean brain responses to food cues. Conclusions: In response to food cues, children with lower peripheral insulin sensitivity exhibited distinctive patterns of neural connectivity, notably in the insula's functional connections, when contrasted with their counterparts with higher peripheral insulin sensitivity. These differences might influence eating behavior and future risk of developing diabetes. |
| format | Article |
| id | doaj-art-d95311b41d8f413588bc4be232d3196f |
| institution | OA Journals |
| issn | 1095-9572 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage |
| spelling | doaj-art-d95311b41d8f413588bc4be232d3196f2025-08-20T01:54:11ZengElsevierNeuroImage1095-95722025-04-0131012115410.1016/j.neuroimage.2025.121154Influence of insulin sensitivity on food cue evoked functional brain connectivity in childrenLorenzo Semeia0Ralf Veit1Sixiu Zhao2Shan Luo3Brendan Angelo4Andreas L. Birkenfeld5Hubert Preissl6Anny H. Xiang7Stephanie Kullmann8Kathleen A. Page9Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tübingen, Tübingen, Germany; German Center for Diabetes Research (DZD), Tübingen, Germany; Graduate Training Centre of Neuroscience, International Max Planck Research School, Tübingen, Germany; Corresponding author at: Institute for Diabetes Research and Metabolic Diseases (IDM) of the Helmholtz Center Munich at the University of Tübingen, fMEG-Center, Otfried-Müller-Str. 47, 72076 Tübingen, Germany.Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tübingen, Tübingen, Germany; German Center for Diabetes Research (DZD), Tübingen, GermanyInstitute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tübingen, Tübingen, Germany; German Center for Diabetes Research (DZD), Tübingen, GermanyDivision of Endocrinology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; Diabetes and Obesity Research Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USADivision of Endocrinology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; Diabetes and Obesity Research Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USAInstitute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tübingen, Tübingen, Germany; German Center for Diabetes Research (DZD), Tübingen, Germany; Department of Internal Medicine, Division of Endocrinology, Diabetology and Nephrology, Eberhard Karls University Tübingen, Tübingen, GermanyInstitute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tübingen, Tübingen, Germany; German Center for Diabetes Research (DZD), Tübingen, Germany; Department of Internal Medicine, Division of Endocrinology, Diabetology and Nephrology, Eberhard Karls University Tübingen, Tübingen, Germany; Department of Pharmacy and Biochemistry, University of Tübingen, GermanyDepartment of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, CA, USAInstitute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tübingen, Tübingen, Germany; German Center for Diabetes Research (DZD), Tübingen, Germany; Department of Internal Medicine, Division of Endocrinology, Diabetology and Nephrology, Eberhard Karls University Tübingen, Tübingen, GermanyDivision of Endocrinology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; Diabetes and Obesity Research Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; Neuroscience Graduate Program, University of Southern California, Los Angeles, CA, USA; Corresponding author.Objective: Insulin resistance during childhood is a risk factor for developing type 2 diabetes and other health problems later in life. Studies in adults have shown that insulin resistance affects regional and network activity in the brain which are vital for behavior, including ingestion and metabolic control. To date, no study has investigated how brain connections during exposure to food cues are association with peripheral insulin sensitivity in children. Methods: We included 53 children (36 girls) between the age of 7–11 years, who underwent an oral Glucose Tolerance Test (oGTT) to estimate peripheral insulin sensitivity (ISI). Brain responses were measured using functional magnetic resonance imaging (fMRI) before and after glucose ingestion. We compared food-cue task-based activity and functional connectivity (FC) between children with lower and higher ISI, adjusted for age and BMIz. Results: Independent of prandial state (i.e., glucose ingestion), children with lower ISI showed higher FC between the anterior insula and caudate and lower FC between the posterior insula and mid temporal cortex than children with higher ISI. Sex differences were found based on prandial state and peripheral insulin sensitivity in the insular FC. No differences were found on mean brain responses to food cues. Conclusions: In response to food cues, children with lower peripheral insulin sensitivity exhibited distinctive patterns of neural connectivity, notably in the insula's functional connections, when contrasted with their counterparts with higher peripheral insulin sensitivity. These differences might influence eating behavior and future risk of developing diabetes.http://www.sciencedirect.com/science/article/pii/S1053811925001569fMRIFood cueFunctional connectivityChildrenInsulin sensitivityObesity |
| spellingShingle | Lorenzo Semeia Ralf Veit Sixiu Zhao Shan Luo Brendan Angelo Andreas L. Birkenfeld Hubert Preissl Anny H. Xiang Stephanie Kullmann Kathleen A. Page Influence of insulin sensitivity on food cue evoked functional brain connectivity in children NeuroImage fMRI Food cue Functional connectivity Children Insulin sensitivity Obesity |
| title | Influence of insulin sensitivity on food cue evoked functional brain connectivity in children |
| title_full | Influence of insulin sensitivity on food cue evoked functional brain connectivity in children |
| title_fullStr | Influence of insulin sensitivity on food cue evoked functional brain connectivity in children |
| title_full_unstemmed | Influence of insulin sensitivity on food cue evoked functional brain connectivity in children |
| title_short | Influence of insulin sensitivity on food cue evoked functional brain connectivity in children |
| title_sort | influence of insulin sensitivity on food cue evoked functional brain connectivity in children |
| topic | fMRI Food cue Functional connectivity Children Insulin sensitivity Obesity |
| url | http://www.sciencedirect.com/science/article/pii/S1053811925001569 |
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