Constraint-induced movement therapy combined with mesenchymal stem cell transplantation promotes myelination and functional recovery by inhibiting PRKCD/MEK/ERK pathway in hemiplegic cerebral palsy rats

Constraint-induced movement therapy combined with mesenchymal stem cell transplantation promotes myelination and functional recovery by inhibiting PRKCD/MEK/ERK pathway in hemiplegic cerebral palsy rats

Abstract Background The core problem of hemiplegic cerebral palsy (HCP) is upper limb motor deficits with high rates of disability. Given the shared goals of stem cell therapy and rehabilitation, this study investigated the synergistic effects of constraint-induced movement therapy (CIMT) and human...

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Bibliographic Details
Main Authors: Xiaolin Guo, Liru Liu, Jie Luo, Tingting Peng Jr., You Wang, Shiya Huang, Xiaoli Zeng, Tingting Peng Sr., Aihua Chen, Mengru Zhong, Yage Zhang, Kaishou Xu, Lu He
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Stem Cell Research & Therapy
Subjects:
Combination therapy
Constraint-induced movement therapy
Mesenchymal stem cells
Motor function
Oligodendrocyte progenitor cells differentiation
Myelination
Online Access:https://doi.org/10.1186/s13287-025-04544-7
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