Prevalence of thyroid disorders in pregnant Arab women: A systematic review and meta-analysis
Since thyroid profile is linked to genes and differing environmental factors, it is essential to evaluate the frequency of thyroid diseases in various ethnicities. The aim of this systematic review and meta-analysis is to explore the pooled prevalence of thyroid disorders in pregnant Arab women. Fol...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2025-04-01
|
| Series: | Journal of Family and Community Medicine |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/jfcm.jfcm_323_24 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849324014328086528 |
|---|---|
| author | Ahmad B. Aamir Rabia Latif Hoor H. Alqudihi Roaa A. Zedan Sarah Hunachagi |
| author_facet | Ahmad B. Aamir Rabia Latif Hoor H. Alqudihi Roaa A. Zedan Sarah Hunachagi |
| author_sort | Ahmad B. Aamir |
| collection | DOAJ |
| description | Since thyroid profile is linked to genes and differing environmental factors, it is essential to evaluate the frequency of thyroid diseases in various ethnicities. The aim of this systematic review and meta-analysis is to explore the pooled prevalence of thyroid disorders in pregnant Arab women. Following the prospective registration (PROSPERO CRD42024590477), four databases (PubMed, Scopus, Web of Science, and Cochrane) were searched systematically to retrieve studies that report the prevalence of thyroid hormone disorders in pregnant Arab women. Data were synthesized using RStudio within a random effect model. Study heterogeneity and data robustness were assessed by I2 and sensitivity analysis, respectively. Egger’s regression asymmetry test and funnel plots were used to explore publication bias. Search results yielded 981 studies from which nine studies were taken. The risk of Bias was “high” in one, “moderate” in five and “low” in three studies. The estimated pooled prevalence were: subclinical hypothyroidism (SCH) 20% (95% confidence interval [CI]: 14%–28%) (I2 = 94%, P < 0.01), overt hypothyroidism (OH) 3% (95% CI: 1%–8%) (I2 = 79%, P < 0.01), isolated hypothyroxinemia (IH) 4% (95% CI: 2%–6%) (I2 = 69%, P = 0.02), unspecified hypothyroidism 27% (95% CI: 10%–45%) (I2 = 98%, P < 0.01), and hyperthyroidism 2% (95% CI: 1%–3%) (I2 = 0%, P = 0.45). No significant publication bias was detected (Egger regression asymmetry test P values; SCH = 0.10; OH = 0.16; IH = 0.62; hyperthyroidism = 0.15). Study showed that in pregnant Arab women, unspecified hypothyroidism is more prevalent than hyperthyroidism. Of the subcategories of hypothyroidism, SCH is the most prevalent followed by IH and OH. |
| format | Article |
| id | doaj-art-d94bcfb4319d4b17a442b80eb53aa10d |
| institution | Kabale University |
| issn | 2229-340X |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Family and Community Medicine |
| spelling | doaj-art-d94bcfb4319d4b17a442b80eb53aa10d2025-08-20T03:48:51ZengWolters Kluwer Medknow PublicationsJournal of Family and Community Medicine2229-340X2025-04-013229110010.4103/jfcm.jfcm_323_24Prevalence of thyroid disorders in pregnant Arab women: A systematic review and meta-analysisAhmad B. AamirRabia LatifHoor H. AlqudihiRoaa A. ZedanSarah HunachagiSince thyroid profile is linked to genes and differing environmental factors, it is essential to evaluate the frequency of thyroid diseases in various ethnicities. The aim of this systematic review and meta-analysis is to explore the pooled prevalence of thyroid disorders in pregnant Arab women. Following the prospective registration (PROSPERO CRD42024590477), four databases (PubMed, Scopus, Web of Science, and Cochrane) were searched systematically to retrieve studies that report the prevalence of thyroid hormone disorders in pregnant Arab women. Data were synthesized using RStudio within a random effect model. Study heterogeneity and data robustness were assessed by I2 and sensitivity analysis, respectively. Egger’s regression asymmetry test and funnel plots were used to explore publication bias. Search results yielded 981 studies from which nine studies were taken. The risk of Bias was “high” in one, “moderate” in five and “low” in three studies. The estimated pooled prevalence were: subclinical hypothyroidism (SCH) 20% (95% confidence interval [CI]: 14%–28%) (I2 = 94%, P < 0.01), overt hypothyroidism (OH) 3% (95% CI: 1%–8%) (I2 = 79%, P < 0.01), isolated hypothyroxinemia (IH) 4% (95% CI: 2%–6%) (I2 = 69%, P = 0.02), unspecified hypothyroidism 27% (95% CI: 10%–45%) (I2 = 98%, P < 0.01), and hyperthyroidism 2% (95% CI: 1%–3%) (I2 = 0%, P = 0.45). No significant publication bias was detected (Egger regression asymmetry test P values; SCH = 0.10; OH = 0.16; IH = 0.62; hyperthyroidism = 0.15). Study showed that in pregnant Arab women, unspecified hypothyroidism is more prevalent than hyperthyroidism. Of the subcategories of hypothyroidism, SCH is the most prevalent followed by IH and OH.https://journals.lww.com/10.4103/jfcm.jfcm_323_24arabshypothyroidismhyperthyroidismpregnancyprevalencethyroid disease |
| spellingShingle | Ahmad B. Aamir Rabia Latif Hoor H. Alqudihi Roaa A. Zedan Sarah Hunachagi Prevalence of thyroid disorders in pregnant Arab women: A systematic review and meta-analysis Journal of Family and Community Medicine arabs hypothyroidism hyperthyroidism pregnancy prevalence thyroid disease |
| title | Prevalence of thyroid disorders in pregnant Arab women: A systematic review and meta-analysis |
| title_full | Prevalence of thyroid disorders in pregnant Arab women: A systematic review and meta-analysis |
| title_fullStr | Prevalence of thyroid disorders in pregnant Arab women: A systematic review and meta-analysis |
| title_full_unstemmed | Prevalence of thyroid disorders in pregnant Arab women: A systematic review and meta-analysis |
| title_short | Prevalence of thyroid disorders in pregnant Arab women: A systematic review and meta-analysis |
| title_sort | prevalence of thyroid disorders in pregnant arab women a systematic review and meta analysis |
| topic | arabs hypothyroidism hyperthyroidism pregnancy prevalence thyroid disease |
| url | https://journals.lww.com/10.4103/jfcm.jfcm_323_24 |
| work_keys_str_mv | AT ahmadbaamir prevalenceofthyroiddisordersinpregnantarabwomenasystematicreviewandmetaanalysis AT rabialatif prevalenceofthyroiddisordersinpregnantarabwomenasystematicreviewandmetaanalysis AT hoorhalqudihi prevalenceofthyroiddisordersinpregnantarabwomenasystematicreviewandmetaanalysis AT roaaazedan prevalenceofthyroiddisordersinpregnantarabwomenasystematicreviewandmetaanalysis AT sarahhunachagi prevalenceofthyroiddisordersinpregnantarabwomenasystematicreviewandmetaanalysis |