Acute Liver Injury Associated with Khat Use in a 24-Year-Old Male
Chewing khat leaves (Catha edulis) is common cultural practice in Eastern African countries. Khat has been implicated in cases of acute liver injury, sometimes leading to liver failure and requiring transplantation. We report the case of a 24-year-old gentleman presenting with symptoms of acute live...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Case Reports in Hepatology |
| Online Access: | http://dx.doi.org/10.1155/2018/2816907 |
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| _version_ | 1850168507424047104 |
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| author | Mara Waters Adam Oxner Sigmund Krajden Richard Sultanian |
| author_facet | Mara Waters Adam Oxner Sigmund Krajden Richard Sultanian |
| author_sort | Mara Waters |
| collection | DOAJ |
| description | Chewing khat leaves (Catha edulis) is common cultural practice in Eastern African countries. Khat has been implicated in cases of acute liver injury, sometimes leading to liver failure and requiring transplantation. We report the case of a 24-year-old gentleman presenting with symptoms of acute liver failure. Bloodwork demonstrated hepatocyte-predominant liver injury. Microbiological and serological hepatitis panels were negative, and his liver biopsy demonstrated acute cholestatic hepatitis. He admitted to regular khat use for several years prior to his presentation. His liver function tests improved with cessation of khat use. This is the first reported case of acute khat-associated hepatitis in Canada. Considering cultural practices such as khat chewing in presentations of acute liver injury are important when caring for diverse patient populations. |
| format | Article |
| id | doaj-art-d9480412d09942e7afdceba6307bddea |
| institution | OA Journals |
| issn | 2090-6587 2090-6595 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hepatology |
| spelling | doaj-art-d9480412d09942e7afdceba6307bddea2025-08-20T02:20:57ZengWileyCase Reports in Hepatology2090-65872090-65952018-01-01201810.1155/2018/28169072816907Acute Liver Injury Associated with Khat Use in a 24-Year-Old MaleMara Waters0Adam Oxner1Sigmund Krajden2Richard Sultanian3Department of Medicine, University of Toronto, Toronto, ON, CanadaDepartment of Medicine, University of Toronto, Toronto, ON, CanadaDivision of Infectious Diseases, St. Joseph’s Health Centre, Toronto, Ontario, CanadaDivision of Gastroenterology, Department of Medicine, University of Alberta, Edmonton, AB, CanadaChewing khat leaves (Catha edulis) is common cultural practice in Eastern African countries. Khat has been implicated in cases of acute liver injury, sometimes leading to liver failure and requiring transplantation. We report the case of a 24-year-old gentleman presenting with symptoms of acute liver failure. Bloodwork demonstrated hepatocyte-predominant liver injury. Microbiological and serological hepatitis panels were negative, and his liver biopsy demonstrated acute cholestatic hepatitis. He admitted to regular khat use for several years prior to his presentation. His liver function tests improved with cessation of khat use. This is the first reported case of acute khat-associated hepatitis in Canada. Considering cultural practices such as khat chewing in presentations of acute liver injury are important when caring for diverse patient populations.http://dx.doi.org/10.1155/2018/2816907 |
| spellingShingle | Mara Waters Adam Oxner Sigmund Krajden Richard Sultanian Acute Liver Injury Associated with Khat Use in a 24-Year-Old Male Case Reports in Hepatology |
| title | Acute Liver Injury Associated with Khat Use in a 24-Year-Old Male |
| title_full | Acute Liver Injury Associated with Khat Use in a 24-Year-Old Male |
| title_fullStr | Acute Liver Injury Associated with Khat Use in a 24-Year-Old Male |
| title_full_unstemmed | Acute Liver Injury Associated with Khat Use in a 24-Year-Old Male |
| title_short | Acute Liver Injury Associated with Khat Use in a 24-Year-Old Male |
| title_sort | acute liver injury associated with khat use in a 24 year old male |
| url | http://dx.doi.org/10.1155/2018/2816907 |
| work_keys_str_mv | AT marawaters acuteliverinjuryassociatedwithkhatuseina24yearoldmale AT adamoxner acuteliverinjuryassociatedwithkhatuseina24yearoldmale AT sigmundkrajden acuteliverinjuryassociatedwithkhatuseina24yearoldmale AT richardsultanian acuteliverinjuryassociatedwithkhatuseina24yearoldmale |