Update on the Use of Nanocarriers and Drug Delivery Systems and Future Directions in Cervical Cancer
Cervical cancer represents a major health problem among females due to its increased mortality rate. The conventional therapies are very aggressive and unsatisfactory when it comes to survival rate, especially in terminal stages, which requires the development of new treatment alternatives. With the...
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| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2022/1636908 |
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| author | Loredana Maria Himiniuc Bogdan Florin Toma Razvan Popovici Ana Maria Grigore Alexandru Hamod Constantin Volovat Simona Volovat Irina Nica Decebal Vasincu Maricel Agop Mihaela Tirnovanu Lacramioara Ochiuz Anca Negura Mihaela Grigore |
| author_facet | Loredana Maria Himiniuc Bogdan Florin Toma Razvan Popovici Ana Maria Grigore Alexandru Hamod Constantin Volovat Simona Volovat Irina Nica Decebal Vasincu Maricel Agop Mihaela Tirnovanu Lacramioara Ochiuz Anca Negura Mihaela Grigore |
| author_sort | Loredana Maria Himiniuc |
| collection | DOAJ |
| description | Cervical cancer represents a major health problem among females due to its increased mortality rate. The conventional therapies are very aggressive and unsatisfactory when it comes to survival rate, especially in terminal stages, which requires the development of new treatment alternatives. With the use of nanotechnology, various chemotherapeutic drugs can be transported via nanocarriers directly to cervical cancerous cells, thus skipping the hepatic first-pass effect and decreasing the rate of chemotherapy side effects. This review comprises various drug delivery systems that were applied in cervical cancer, such as lipid-based nanocarriers, polymeric and dendrimeric nanoparticles, carbon-based nanoparticles, metallic nanoparticles, inorganic nanoparticles, micellar nanocarriers, and protein and polysaccharide nanoparticles. Nanoparticles have a great therapeutic potential by increasing the pharmacological activity, drug solubility, and bioavailability. Through their mechanisms, they highly increase the toxicity in the targeted cervical tumor cells or tissues by linking to specific ligands. In addition, a nondifferentiable model is proposed through holographic implementation in the dynamics of drug delivery dynamics. As any hologram functions as a deep learning process, the artificial intelligence can be proposed as a new analyzing method in cervical cancer. |
| format | Article |
| id | doaj-art-d9475df6de674c8e9ce174f954ee5691 |
| institution | OA Journals |
| issn | 2314-7156 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-d9475df6de674c8e9ce174f954ee56912025-08-20T02:20:57ZengWileyJournal of Immunology Research2314-71562022-01-01202210.1155/2022/1636908Update on the Use of Nanocarriers and Drug Delivery Systems and Future Directions in Cervical CancerLoredana Maria Himiniuc0Bogdan Florin Toma1Razvan Popovici2Ana Maria Grigore3Alexandru Hamod4Constantin Volovat5Simona Volovat6Irina Nica7Decebal Vasincu8Maricel Agop9Mihaela Tirnovanu10Lacramioara Ochiuz11Anca Negura12Mihaela Grigore13”Grigore T. Popa” University of Medicine and Pharmacy”Grigore T. Popa” University of Medicine and PharmacyDepartment of Obstetrics and Gynecology”Grigore T. Popa” University of Medicine and PharmacyRegional Institute of OncologyCenter of Oncology EuroclinicCenter of Oncology EuroclinicDepartment of OdontologyDepartment of Dental and Oro-Maxillo-Facial SurgeryDepartment of PhysicsDepartment of Obstetrics and GynecologyDepartment of Pharmaceutical and Biotechnological Drug IndustryOncogenetics DepartmentDepartment of Obstetrics and GynecologyCervical cancer represents a major health problem among females due to its increased mortality rate. The conventional therapies are very aggressive and unsatisfactory when it comes to survival rate, especially in terminal stages, which requires the development of new treatment alternatives. With the use of nanotechnology, various chemotherapeutic drugs can be transported via nanocarriers directly to cervical cancerous cells, thus skipping the hepatic first-pass effect and decreasing the rate of chemotherapy side effects. This review comprises various drug delivery systems that were applied in cervical cancer, such as lipid-based nanocarriers, polymeric and dendrimeric nanoparticles, carbon-based nanoparticles, metallic nanoparticles, inorganic nanoparticles, micellar nanocarriers, and protein and polysaccharide nanoparticles. Nanoparticles have a great therapeutic potential by increasing the pharmacological activity, drug solubility, and bioavailability. Through their mechanisms, they highly increase the toxicity in the targeted cervical tumor cells or tissues by linking to specific ligands. In addition, a nondifferentiable model is proposed through holographic implementation in the dynamics of drug delivery dynamics. As any hologram functions as a deep learning process, the artificial intelligence can be proposed as a new analyzing method in cervical cancer.http://dx.doi.org/10.1155/2022/1636908 |
| spellingShingle | Loredana Maria Himiniuc Bogdan Florin Toma Razvan Popovici Ana Maria Grigore Alexandru Hamod Constantin Volovat Simona Volovat Irina Nica Decebal Vasincu Maricel Agop Mihaela Tirnovanu Lacramioara Ochiuz Anca Negura Mihaela Grigore Update on the Use of Nanocarriers and Drug Delivery Systems and Future Directions in Cervical Cancer Journal of Immunology Research |
| title | Update on the Use of Nanocarriers and Drug Delivery Systems and Future Directions in Cervical Cancer |
| title_full | Update on the Use of Nanocarriers and Drug Delivery Systems and Future Directions in Cervical Cancer |
| title_fullStr | Update on the Use of Nanocarriers and Drug Delivery Systems and Future Directions in Cervical Cancer |
| title_full_unstemmed | Update on the Use of Nanocarriers and Drug Delivery Systems and Future Directions in Cervical Cancer |
| title_short | Update on the Use of Nanocarriers and Drug Delivery Systems and Future Directions in Cervical Cancer |
| title_sort | update on the use of nanocarriers and drug delivery systems and future directions in cervical cancer |
| url | http://dx.doi.org/10.1155/2022/1636908 |
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