Influence of Socioeconomic Status on the Association Between Pregnancy Complications and Premature Coronary Artery Disease: Linking Three Cohorts
Background: We hypothesized that there is an influence of socioeconomic status (SES) on association between pregnancy complications and premature coronary artery disease (PCAD) risk. Materials and Methods: This project involved a data linkage approach merging three databases of South Australian coho...
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Mary Ann Liebert
2024-04-01
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| Series: | Women's Health Reports |
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| Online Access: | https://www.liebertpub.com/doi/10.1089/whr.2023.0092 |
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| author | Adeel Khoja Prabha H. Andraweera Rosanna Tavella Tiffany K. Gill Gustaaf A. Dekker Claire T. Roberts Suzanne Edwards Margaret A. Arstall |
| author_facet | Adeel Khoja Prabha H. Andraweera Rosanna Tavella Tiffany K. Gill Gustaaf A. Dekker Claire T. Roberts Suzanne Edwards Margaret A. Arstall |
| author_sort | Adeel Khoja |
| collection | DOAJ |
| description | Background: We hypothesized that there is an influence of socioeconomic status (SES) on association between pregnancy complications and premature coronary artery disease (PCAD) risk. Materials and Methods: This project involved a data linkage approach merging three databases of South Australian cohorts using retrospective, age-matched case–control study design. Cases (n = 721), that is, women aged <60 years from Coronary Angiogram Database of South Australia (CADOSA) were linked to South Australian Perinatal Statistics Collection (SAPSC) to ascertain prior pregnancy outcomes and SES. Controls (n = 194) were selected from North West Adelaide Health Study (NWAHS), comprising women who were healthy or had health conditions unrelated to CAD, age matched to CADOSA (±5 years), and linked to SAPSC to determine prior pregnancy outcomes and SES. This project performed comparative analysis of SES using socioeconomic indexes for areas–index of relative socioeconomic advantage and disadvantage (SEIFA-IRSAD) scores across three databases. Results: Findings revealed that SEIFA-IRSAD scores at the time of pregnancy (p-value = 0.005) and increase in SEIFA-IRSAD scores over time (p-value = 0.040) were significantly associated with PCAD. In addition, when models were adjusted for SEIFA-IRSAD scores at the time of pregnancy and age, risk factors including placenta-mediated pregnancy complications such as preterm birth (odds ratio [OR] = 4.77, 95% confidence interval [CI]: 1.74–13.03) and history of a miscarriage (OR = 2.14, 95% CI: 1.02–4.49), and cardiovascular disease (CVD) risk factors including smoking (OR = 8.60, 95% CI: 3.25–22.75) were significantly associated with PCAD. When the model was adjusted for change in SEIFA-IRSAD scores (from CADOSA/NWAHS to SAPSC) and age, pregnancy-mediated pregnancy complications including preterm birth (OR = 4.40, 95% CI: 1.61–12.05) and history of a miscarriage (OR = 2.09, 95% CI: 1.00–4.35), and CVD risk factor smoking (OR = 8.75, 95% CI: 3.32–23.07) were significantly associated with PCAD. Conclusion: SES at the time of pregnancy and change in SES were not associated with PCAD risk. |
| format | Article |
| id | doaj-art-d9470d0da9af41618915a449b2939ff6 |
| institution | OA Journals |
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| language | English |
| publishDate | 2024-04-01 |
| publisher | Mary Ann Liebert |
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| spelling | doaj-art-d9470d0da9af41618915a449b2939ff62025-08-20T02:31:48ZengMary Ann LiebertWomen's Health Reports2688-48442024-04-015112013110.1089/whr.2023.0092Influence of Socioeconomic Status on the Association Between Pregnancy Complications and Premature Coronary Artery Disease: Linking Three CohortsAdeel Khoja0Prabha H. Andraweera1Rosanna Tavella2Tiffany K. Gill3Gustaaf A. Dekker4Claire T. Roberts5Suzanne Edwards6Margaret A. Arstall7Department of Medicine, Adelaide Medical School, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, Australia.Department of Medicine, Adelaide Medical School, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, Australia.Department of Medicine, Adelaide Medical School, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, Australia.Department of Medicine, Adelaide Medical School, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, Australia.Department of Medicine, Adelaide Medical School, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, Australia.Department of Medicine, Adelaide Medical School, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, Australia.Department of Medicine, Flinders Health and Medical Research Institute, Flinders University, Bedford Park, Australia.Department of Cardiology, Cardiology Unit, Northern Adelaide Local Health Network, Adelaide, Australia.Background: We hypothesized that there is an influence of socioeconomic status (SES) on association between pregnancy complications and premature coronary artery disease (PCAD) risk. Materials and Methods: This project involved a data linkage approach merging three databases of South Australian cohorts using retrospective, age-matched case–control study design. Cases (n = 721), that is, women aged <60 years from Coronary Angiogram Database of South Australia (CADOSA) were linked to South Australian Perinatal Statistics Collection (SAPSC) to ascertain prior pregnancy outcomes and SES. Controls (n = 194) were selected from North West Adelaide Health Study (NWAHS), comprising women who were healthy or had health conditions unrelated to CAD, age matched to CADOSA (±5 years), and linked to SAPSC to determine prior pregnancy outcomes and SES. This project performed comparative analysis of SES using socioeconomic indexes for areas–index of relative socioeconomic advantage and disadvantage (SEIFA-IRSAD) scores across three databases. Results: Findings revealed that SEIFA-IRSAD scores at the time of pregnancy (p-value = 0.005) and increase in SEIFA-IRSAD scores over time (p-value = 0.040) were significantly associated with PCAD. In addition, when models were adjusted for SEIFA-IRSAD scores at the time of pregnancy and age, risk factors including placenta-mediated pregnancy complications such as preterm birth (odds ratio [OR] = 4.77, 95% confidence interval [CI]: 1.74–13.03) and history of a miscarriage (OR = 2.14, 95% CI: 1.02–4.49), and cardiovascular disease (CVD) risk factors including smoking (OR = 8.60, 95% CI: 3.25–22.75) were significantly associated with PCAD. When the model was adjusted for change in SEIFA-IRSAD scores (from CADOSA/NWAHS to SAPSC) and age, pregnancy-mediated pregnancy complications including preterm birth (OR = 4.40, 95% CI: 1.61–12.05) and history of a miscarriage (OR = 2.09, 95% CI: 1.00–4.35), and CVD risk factor smoking (OR = 8.75, 95% CI: 3.32–23.07) were significantly associated with PCAD. Conclusion: SES at the time of pregnancy and change in SES were not associated with PCAD risk.https://www.liebertpub.com/doi/10.1089/whr.2023.0092coronary artery diseasesocioeconomic statuspregnancy complicationsprematuredata linkagedatabases |
| spellingShingle | Adeel Khoja Prabha H. Andraweera Rosanna Tavella Tiffany K. Gill Gustaaf A. Dekker Claire T. Roberts Suzanne Edwards Margaret A. Arstall Influence of Socioeconomic Status on the Association Between Pregnancy Complications and Premature Coronary Artery Disease: Linking Three Cohorts Women's Health Reports coronary artery disease socioeconomic status pregnancy complications premature data linkage databases |
| title | Influence of Socioeconomic Status on the Association Between Pregnancy Complications and Premature Coronary Artery Disease: Linking Three Cohorts |
| title_full | Influence of Socioeconomic Status on the Association Between Pregnancy Complications and Premature Coronary Artery Disease: Linking Three Cohorts |
| title_fullStr | Influence of Socioeconomic Status on the Association Between Pregnancy Complications and Premature Coronary Artery Disease: Linking Three Cohorts |
| title_full_unstemmed | Influence of Socioeconomic Status on the Association Between Pregnancy Complications and Premature Coronary Artery Disease: Linking Three Cohorts |
| title_short | Influence of Socioeconomic Status on the Association Between Pregnancy Complications and Premature Coronary Artery Disease: Linking Three Cohorts |
| title_sort | influence of socioeconomic status on the association between pregnancy complications and premature coronary artery disease linking three cohorts |
| topic | coronary artery disease socioeconomic status pregnancy complications premature data linkage databases |
| url | https://www.liebertpub.com/doi/10.1089/whr.2023.0092 |
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