Clinical outcomes after immune checkpoint inhibitor-associated acute kidney injury: a cohort study
Objectives Immune checkpoint inhibitors (ICPi) have significantly improved survival for patients with advanced cancers. However, the occurrence of ICPi-associated acute kidney injury (AKI) and its clinical impact remains unclear. This study evaluates the effects of ICPi-associated AKI (ICPi-AKI) on...
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BMJ Publishing Group
2025-02-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/15/2/e092752.full |
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| author | Vin-Cent Wu Ting-Ya Yang Min-Hsiang Chuang Hong-Min Lin Heng-Chih Pan Yun Chou Jui-Yi Chen |
| author_facet | Vin-Cent Wu Ting-Ya Yang Min-Hsiang Chuang Hong-Min Lin Heng-Chih Pan Yun Chou Jui-Yi Chen |
| author_sort | Vin-Cent Wu |
| collection | DOAJ |
| description | Objectives Immune checkpoint inhibitors (ICPi) have significantly improved survival for patients with advanced cancers. However, the occurrence of ICPi-associated acute kidney injury (AKI) and its clinical impact remains unclear. This study evaluates the effects of ICPi-associated AKI (ICPi-AKI) on mortality, kidney and cardiovascular outcomes in patients undergoing ICPi treatments.Design This multicentre retrospective cohort study with propensity score matching to balance baseline characteristics. The International Classification of Diseases, 10th Revision codes were used to identify individuals with cancer and treated with ICPi concurrently. Kaplan-Meier analyses coupled with log-rank tests were conducted to estimate the survival probabilities.Setting Data were sourced from the TriNetX database spanning records from 25 March 2011 to 5 April 2024.Participants Patients with cancer aged ≥18 years treated with ICPi with or without AKI occurrence.Primary and secondary outcome measures The primary outcome was all-cause mortality, and secondary outcomes included major adverse kidney events (MAKE), major adverse cardiovascular events (MACE), the composite of MAKE or MACE with death, and end-stage renal disease.Results The study identified 926 patients with cancer who developed ICPi-AKI (mean age, 67.1±11.8 years; 57.4% men). The control group consisted of 48 147 patients treated with ICPi but did not develop AKI (mean age, 65.3±13.1 years; 53.7% men). After matching, the ICPi-AKI group exhibited a higher risk of all-cause mortality (HR=1.27; 95% CI 1.02 to 1.61), MAKE (HR=3.83; 95% CI 1.72 to 8.40), MACE (HR=1.35; 95% CI 1.03 to 1.75)) compared with the non-ICPi-AKI group. Subgroup analyses confirmed these findings across various patient’s characteristics.Conclusion Individuals with ICPi-AKI are associated with an increased risk of all-cause mortality, MAKE and MACE. Enhancing awareness and timely intervention for ICPi-AKI are crucial for improving prognosis and reducing complications among patients with cancer. |
| format | Article |
| id | doaj-art-d945d051bf734ba0b456eb545e85617a |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-d945d051bf734ba0b456eb545e85617a2025-02-08T07:20:13ZengBMJ Publishing GroupBMJ Open2044-60552025-02-0115210.1136/bmjopen-2024-092752Clinical outcomes after immune checkpoint inhibitor-associated acute kidney injury: a cohort studyVin-Cent Wu0Ting-Ya Yang1Min-Hsiang Chuang2Hong-Min Lin3Heng-Chih Pan4Yun Chou5Jui-Yi Chen63 Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan1 Department of Family Medicine, Chi Mei Medical Center, Tainan, Taiwan2 Division of Nephrology, Department of Internal Medicine, Chi Mei Medical Center, Tainan, Taiwan1 Department of Family Medicine, Chi Mei Medical Center, Tainan, Taiwan4 Department of Internal Medicine, Keelung Chang Gung Memorial Hospital, Keelung, Taiwan5 Department of Pediatrics, Chi Mei Medical Center, Tainan, Taiwan2 Division of Nephrology, Department of Internal Medicine, Chi Mei Medical Center, Tainan, TaiwanObjectives Immune checkpoint inhibitors (ICPi) have significantly improved survival for patients with advanced cancers. However, the occurrence of ICPi-associated acute kidney injury (AKI) and its clinical impact remains unclear. This study evaluates the effects of ICPi-associated AKI (ICPi-AKI) on mortality, kidney and cardiovascular outcomes in patients undergoing ICPi treatments.Design This multicentre retrospective cohort study with propensity score matching to balance baseline characteristics. The International Classification of Diseases, 10th Revision codes were used to identify individuals with cancer and treated with ICPi concurrently. Kaplan-Meier analyses coupled with log-rank tests were conducted to estimate the survival probabilities.Setting Data were sourced from the TriNetX database spanning records from 25 March 2011 to 5 April 2024.Participants Patients with cancer aged ≥18 years treated with ICPi with or without AKI occurrence.Primary and secondary outcome measures The primary outcome was all-cause mortality, and secondary outcomes included major adverse kidney events (MAKE), major adverse cardiovascular events (MACE), the composite of MAKE or MACE with death, and end-stage renal disease.Results The study identified 926 patients with cancer who developed ICPi-AKI (mean age, 67.1±11.8 years; 57.4% men). The control group consisted of 48 147 patients treated with ICPi but did not develop AKI (mean age, 65.3±13.1 years; 53.7% men). After matching, the ICPi-AKI group exhibited a higher risk of all-cause mortality (HR=1.27; 95% CI 1.02 to 1.61), MAKE (HR=3.83; 95% CI 1.72 to 8.40), MACE (HR=1.35; 95% CI 1.03 to 1.75)) compared with the non-ICPi-AKI group. Subgroup analyses confirmed these findings across various patient’s characteristics.Conclusion Individuals with ICPi-AKI are associated with an increased risk of all-cause mortality, MAKE and MACE. Enhancing awareness and timely intervention for ICPi-AKI are crucial for improving prognosis and reducing complications among patients with cancer.https://bmjopen.bmj.com/content/15/2/e092752.full |
| spellingShingle | Vin-Cent Wu Ting-Ya Yang Min-Hsiang Chuang Hong-Min Lin Heng-Chih Pan Yun Chou Jui-Yi Chen Clinical outcomes after immune checkpoint inhibitor-associated acute kidney injury: a cohort study BMJ Open |
| title | Clinical outcomes after immune checkpoint inhibitor-associated acute kidney injury: a cohort study |
| title_full | Clinical outcomes after immune checkpoint inhibitor-associated acute kidney injury: a cohort study |
| title_fullStr | Clinical outcomes after immune checkpoint inhibitor-associated acute kidney injury: a cohort study |
| title_full_unstemmed | Clinical outcomes after immune checkpoint inhibitor-associated acute kidney injury: a cohort study |
| title_short | Clinical outcomes after immune checkpoint inhibitor-associated acute kidney injury: a cohort study |
| title_sort | clinical outcomes after immune checkpoint inhibitor associated acute kidney injury a cohort study |
| url | https://bmjopen.bmj.com/content/15/2/e092752.full |
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