DDAH1 Promotes Cisplatin Chemoresistance in Patients with Locally Advanced Nasopharyngeal Carcinoma via the EGFR‐JAK2‐STAT3 Pathway

DDAH1 Promotes Cisplatin Chemoresistance in Patients with Locally Advanced Nasopharyngeal Carcinoma via the EGFR‐JAK2‐STAT3 Pathway

Abstract Cisplatin‐based induction chemotherapy (IC) improves survival in patients with locally advanced nasopharyngeal carcinoma (LANPC). However, ≈30% of patients with LANPC receiving IC develop chemoresistance, and 20% experience disease progression. The relation between chemoresistance and Dimet...

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Main Authors: Jin‐Hao Yang, Li Yuan, Qiu‐Yan Chen, Kai‐Qi Lan, Liang‐Ji Li, Yu‐Chen Li, Xiao‐Yun Li, Xue‐Song Sun, Lin‐Quan Tang, Sai‐Lan Liu, Hai‐Qiang Mai
Format: Article
Language:English
Published: Wiley 2025-08-01
Series:Advanced Science
Subjects:
cisplatin resistance
DDAH1
EGFR
JAK2‐STAT3 pathway
nasopharyngeal carcinoma
nimotuzumab
Online Access:https://doi.org/10.1002/advs.202503647
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