NMR Data Analysis of Acarbose
Acarbose, an α-glucosidase inhibitor, has been widely used in the treatment of type-II diabetes due to its unique mechanism of action. In this study, comprehensive and accurate 1H and 13C NMR data of acarbose in DMSO-d6, including 1H NMR data of all hydroxyl groups of acarbose as well as 1H and 13C...
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| Format: | Article |
| Language: | zho |
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Science Press
2025-06-01
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| Series: | Chinese Journal of Magnetic Resonance |
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| Online Access: | http://121.43.60.238/bpxzz/article/2025/1000-4556/1000-4556-42-2-184.shtml |
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| author | LI Yujiang ZHAO Wei TAO Le LU Bohua ZHENG Guo ZHANG Haiyan GUO Xiaohe ZHAO Tianzeng |
| author_facet | LI Yujiang ZHAO Wei TAO Le LU Bohua ZHENG Guo ZHANG Haiyan GUO Xiaohe ZHAO Tianzeng |
| author_sort | LI Yujiang |
| collection | DOAJ |
| description | Acarbose, an α-glucosidase inhibitor, has been widely used in the treatment of type-II diabetes due to its unique mechanism of action. In this study, comprehensive and accurate 1H and 13C NMR data of acarbose in DMSO-d6, including 1H NMR data of all hydroxyl groups of acarbose as well as 1H and 13C NMR data of the dual signal of C-ring α and β, were reported for the first time. The assignment of 1H and 13C NMR data was conducted using DEPT-135, 1H-1H COSY, 1H-13C HSQC, and 1H-13C HMBC techniques. The molecular structure of acarbose was confirmed, providing a reliable data basis for the safety and quality control of acarbose drugs. |
| format | Article |
| id | doaj-art-d943443c07254bf5a3c7ddec2bf0c563 |
| institution | Kabale University |
| issn | 1000-4556 |
| language | zho |
| publishDate | 2025-06-01 |
| publisher | Science Press |
| record_format | Article |
| series | Chinese Journal of Magnetic Resonance |
| spelling | doaj-art-d943443c07254bf5a3c7ddec2bf0c5632025-08-20T03:45:10ZzhoScience PressChinese Journal of Magnetic Resonance1000-45562025-06-0142218419410.11938/cjmr20243125NMR Data Analysis of AcarboseLI Yujiang0ZHAO Wei1TAO Le2LU Bohua3ZHENG Guo4ZHANG Haiyan5GUO Xiaohe6ZHAO Tianzeng7High&New Technology Research Center of Henan Academy of Sciences, Zhengzhou, 450002, ChinaHigh&New Technology Research Center of Henan Academy of Sciences, Zhengzhou, 450002, ChinaHigh&New Technology Research Center of Henan Academy of Sciences, Zhengzhou, 450002, ChinaHigh&New Technology Research Center of Henan Academy of Sciences, Zhengzhou, 450002, ChinaHigh&New Technology Research Center of Henan Academy of Sciences, Zhengzhou, 450002, ChinaKey Laboratory of Natural Products, Henan Academy of Sciences, Zhengzhou, 450002, ChinaHigh&New Technology Research Center of Henan Academy of Sciences, Zhengzhou, 450002, China1. High&New Technology Research Center of Henan Academy of Sciences, Zhengzhou, 450002, China 2. Key Laboratory of Natural Products, Henan Academy of Sciences, Zhengzhou, 450002, ChinaAcarbose, an α-glucosidase inhibitor, has been widely used in the treatment of type-II diabetes due to its unique mechanism of action. In this study, comprehensive and accurate 1H and 13C NMR data of acarbose in DMSO-d6, including 1H NMR data of all hydroxyl groups of acarbose as well as 1H and 13C NMR data of the dual signal of C-ring α and β, were reported for the first time. The assignment of 1H and 13C NMR data was conducted using DEPT-135, 1H-1H COSY, 1H-13C HSQC, and 1H-13C HMBC techniques. The molecular structure of acarbose was confirmed, providing a reliable data basis for the safety and quality control of acarbose drugs.http://121.43.60.238/bpxzz/article/2025/1000-4556/1000-4556-42-2-184.shtmlliquid-state nmrstructural assignment2d nmracarbose |
| spellingShingle | LI Yujiang ZHAO Wei TAO Le LU Bohua ZHENG Guo ZHANG Haiyan GUO Xiaohe ZHAO Tianzeng NMR Data Analysis of Acarbose Chinese Journal of Magnetic Resonance liquid-state nmr structural assignment 2d nmr acarbose |
| title | NMR Data Analysis of Acarbose |
| title_full | NMR Data Analysis of Acarbose |
| title_fullStr | NMR Data Analysis of Acarbose |
| title_full_unstemmed | NMR Data Analysis of Acarbose |
| title_short | NMR Data Analysis of Acarbose |
| title_sort | nmr data analysis of acarbose |
| topic | liquid-state nmr structural assignment 2d nmr acarbose |
| url | http://121.43.60.238/bpxzz/article/2025/1000-4556/1000-4556-42-2-184.shtml |
| work_keys_str_mv | AT liyujiang nmrdataanalysisofacarbose AT zhaowei nmrdataanalysisofacarbose AT taole nmrdataanalysisofacarbose AT lubohua nmrdataanalysisofacarbose AT zhengguo nmrdataanalysisofacarbose AT zhanghaiyan nmrdataanalysisofacarbose AT guoxiaohe nmrdataanalysisofacarbose AT zhaotianzeng nmrdataanalysisofacarbose |