A multicenter longitudinal study of cholinergic subgroups in Parkinson disease

A multicenter longitudinal study of cholinergic subgroups in Parkinson disease

Abstract Parkinson disease (PD) is a heterogeneous syndrome. There is a need for biology-driven subtyping to inform specific therapeutic strategies. In a two-center study with de novo and established PD cohorts, we use vesicular acetylcholine transporter ligand [18F]FEOBV brain PET to assess choline...

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Main Authors: Nicolaas I. Bohnen, Stiven Roytman, Sygrid van der Zee, Giulia Carli, Fotini Michalakis, Austin Luker, Sofie Slingerland, Kirk A. Frey, Peter J. H. Scott, Robert A. Koeppe, Teus van Laar, Roger L. Albin, Prabesh Kanel
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60815-0
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