Small Molecule Derived From Carboxyethylpyrrole Protein Adducts Promotes Angiogenesis in a Mouse Model of Peripheral Arterial Disease

Small Molecule Derived From Carboxyethylpyrrole Protein Adducts Promotes Angiogenesis in a Mouse Model of Peripheral Arterial Disease

Background CEP (ω‐[2‐carboxyethyl]pyrrole) protein adducts are the end products of lipid oxidation associated with inflammation and have been implicated in the induction of angiogenesis in pathological conditions such as tissue ischemia. We synthesized small molecules derived from CEP protein adduct...

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Bibliographic Details
Main Authors: Luqia Hou, Guang Yang, Shibing Tang, Cynthia Alcazar, Prajakta Joshi, Zachary Strassberg, Michael Kim, Masashi Kawamura, Y. Joseph Woo, Joseph Shrager, Sheng Ding, Ngan F. Huang
Format: Article
Language:English
Published: Wiley 2018-09-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
angiogenesis
endothelial cell
peripheral vascular disease
small molecules
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.118.009234
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