Cryptococcal meningitis post-covid-19 infection: Immunomodulation, a double-edged sword

Cryptococcal meningitis is an opportunistic infection associated with altered immunity. Immunomodulatory agent use in severe coronavirus disease 2019 (COVID-19) may predispose such infections. Here, we present a 75-year-old male patient who presented with fever and altered general status after seve...

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Bibliographic Details
Main Authors: Hilal W Abdessamad, Michel Achkar, Amal Al Zoghbi, Mohamad Fleifel, Abdul Rahman Ousta, Ahmad Kassar, Nadia L Samaha, Rita Nemr, Anna Farra, Jacques E Mokhbat, Rola Husni
Format: Article
Language:English
Published: The Journal of Infection in Developing Countries 2023-05-01
Series:Journal of Infection in Developing Countries
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Online Access:https://jidc.org/index.php/journal/article/view/17170
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Summary:Cryptococcal meningitis is an opportunistic infection associated with altered immunity. Immunomodulatory agent use in severe coronavirus disease 2019 (COVID-19) may predispose such infections. Here, we present a 75-year-old male patient who presented with fever and altered general status after severe COVID-19 infection and developed cryptococcal meningitis. Opportunistic infection may arise from the use of immunomodulation in severe COVID-19, especially in the elderly population. This article describes the case and extensively reviews cryptococcal disease post-COVID-19 literature, highlighting the risk from immunosuppressive treatment.
ISSN:1972-2680