Health-related quality of life in health states corresponding to different stages of perianal fistula associated with Crohn’s disease: a quantitative evaluation of patients and non-patients in Japan
ABSTRACTBackground Perianal fistula (PF), a complication of Crohn’s disease (CD), affects health-related quality of life (QOL).Objective To elucidate QOL of health states corresponding to different stages of PF associated with CD in Japan.Method This cross-sectional, observational, web-based questio...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-12-01
|
| Series: | Journal of Market Access & Health Policy |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/20016689.2023.2166374 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849473183347900416 |
|---|---|
| author | Masafumi Kato Mariko Yoneyama-Hirozane Katsuhiko Iwasaki Mao Matsubayashi Ataru Igarashi |
| author_facet | Masafumi Kato Mariko Yoneyama-Hirozane Katsuhiko Iwasaki Mao Matsubayashi Ataru Igarashi |
| author_sort | Masafumi Kato |
| collection | DOAJ |
| description | ABSTRACTBackground Perianal fistula (PF), a complication of Crohn’s disease (CD), affects health-related quality of life (QOL).Objective To elucidate QOL of health states corresponding to different stages of PF associated with CD in Japan.Method This cross-sectional, observational, web-based questionnaire survey assessed eight different health states in patients with CD and PF and individuals without CD (non-patients) from the Medilead Healthcare Panel (MHP) and determined the utility values (QOL scores) in each health state by the time trade-off method. In patients, we determined also the utility value of the current health state associated with CD and the PF. The analysis excluded respondents with logical inconsistencies.Results The analysis included 82 patients and 576 non-patients with the same sex and age distribution as the Japanese population. In both groups, mean utility values were higher in remission (patients, 0.78; non-patients, 0.51) than in non-remission states, with lowest values for poor prognosis after proctectomy (patients, 0.13; non-patients, −0.10) and highest values for the state with mild symptoms (patients, 0.60; non-patients, 0.30). In patients, the mean utility value of the current health state was 0.71.Conclusion QOL decreases with increasing severity of PF and is lower for good prognosis after proctostomy than for remission. |
| format | Article |
| id | doaj-art-d9332171345e4012b28daa061600ae14 |
| institution | Kabale University |
| issn | 2001-6689 |
| language | English |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Market Access & Health Policy |
| spelling | doaj-art-d9332171345e4012b28daa061600ae142025-08-20T03:24:15ZengMDPI AGJournal of Market Access & Health Policy2001-66892023-12-0111110.1080/20016689.2023.2166374Health-related quality of life in health states corresponding to different stages of perianal fistula associated with Crohn’s disease: a quantitative evaluation of patients and non-patients in JapanMasafumi Kato0Mariko Yoneyama-Hirozane1Katsuhiko Iwasaki2Mao Matsubayashi3Ataru Igarashi4Japan Pharma Business Unit, Takeda Pharmaceutical Company Limited, Tokyo, JapanJapan Pharma Business Unit, Takeda Pharmaceutical Company Limited, Tokyo, JapanDepartment of Data Science, Medilead, Inc, Tokyo, JapanDepartment of Gastroenterology, Graduate School of Medicine, Yokohama City University, Yokohama, JapanUnit of Public Health and Preventive Medicine, School of Medicine, Yokohama City University, Yokohama, JapanABSTRACTBackground Perianal fistula (PF), a complication of Crohn’s disease (CD), affects health-related quality of life (QOL).Objective To elucidate QOL of health states corresponding to different stages of PF associated with CD in Japan.Method This cross-sectional, observational, web-based questionnaire survey assessed eight different health states in patients with CD and PF and individuals without CD (non-patients) from the Medilead Healthcare Panel (MHP) and determined the utility values (QOL scores) in each health state by the time trade-off method. In patients, we determined also the utility value of the current health state associated with CD and the PF. The analysis excluded respondents with logical inconsistencies.Results The analysis included 82 patients and 576 non-patients with the same sex and age distribution as the Japanese population. In both groups, mean utility values were higher in remission (patients, 0.78; non-patients, 0.51) than in non-remission states, with lowest values for poor prognosis after proctectomy (patients, 0.13; non-patients, −0.10) and highest values for the state with mild symptoms (patients, 0.60; non-patients, 0.30). In patients, the mean utility value of the current health state was 0.71.Conclusion QOL decreases with increasing severity of PF and is lower for good prognosis after proctostomy than for remission.https://www.tandfonline.com/doi/10.1080/20016689.2023.2166374JapaneseCrohn’s diseaseperianal fistulaquality of lifeutility valuetime trade-off |
| spellingShingle | Masafumi Kato Mariko Yoneyama-Hirozane Katsuhiko Iwasaki Mao Matsubayashi Ataru Igarashi Health-related quality of life in health states corresponding to different stages of perianal fistula associated with Crohn’s disease: a quantitative evaluation of patients and non-patients in Japan Journal of Market Access & Health Policy Japanese Crohn’s disease perianal fistula quality of life utility value time trade-off |
| title | Health-related quality of life in health states corresponding to different stages of perianal fistula associated with Crohn’s disease: a quantitative evaluation of patients and non-patients in Japan |
| title_full | Health-related quality of life in health states corresponding to different stages of perianal fistula associated with Crohn’s disease: a quantitative evaluation of patients and non-patients in Japan |
| title_fullStr | Health-related quality of life in health states corresponding to different stages of perianal fistula associated with Crohn’s disease: a quantitative evaluation of patients and non-patients in Japan |
| title_full_unstemmed | Health-related quality of life in health states corresponding to different stages of perianal fistula associated with Crohn’s disease: a quantitative evaluation of patients and non-patients in Japan |
| title_short | Health-related quality of life in health states corresponding to different stages of perianal fistula associated with Crohn’s disease: a quantitative evaluation of patients and non-patients in Japan |
| title_sort | health related quality of life in health states corresponding to different stages of perianal fistula associated with crohn s disease a quantitative evaluation of patients and non patients in japan |
| topic | Japanese Crohn’s disease perianal fistula quality of life utility value time trade-off |
| url | https://www.tandfonline.com/doi/10.1080/20016689.2023.2166374 |
| work_keys_str_mv | AT masafumikato healthrelatedqualityoflifeinhealthstatescorrespondingtodifferentstagesofperianalfistulaassociatedwithcrohnsdiseaseaquantitativeevaluationofpatientsandnonpatientsinjapan AT marikoyoneyamahirozane healthrelatedqualityoflifeinhealthstatescorrespondingtodifferentstagesofperianalfistulaassociatedwithcrohnsdiseaseaquantitativeevaluationofpatientsandnonpatientsinjapan AT katsuhikoiwasaki healthrelatedqualityoflifeinhealthstatescorrespondingtodifferentstagesofperianalfistulaassociatedwithcrohnsdiseaseaquantitativeevaluationofpatientsandnonpatientsinjapan AT maomatsubayashi healthrelatedqualityoflifeinhealthstatescorrespondingtodifferentstagesofperianalfistulaassociatedwithcrohnsdiseaseaquantitativeevaluationofpatientsandnonpatientsinjapan AT ataruigarashi healthrelatedqualityoflifeinhealthstatescorrespondingtodifferentstagesofperianalfistulaassociatedwithcrohnsdiseaseaquantitativeevaluationofpatientsandnonpatientsinjapan |