Liposomal SunActive versus conventional iron for treatment of iron-deficiency anemia in children aged 2–12 years: a prospective randomized controlled trial
Background Liposomal iron, a novel oral formulation of ferric pyrophosphate that demonstrates improved gastrointestinal absorption and bioavailability with fewer side effects than conventional iron, represents a significant advancement in the treatment of iron-deficiency anemia (IDA). Purpose To con...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
The Korean Pediatric Society
2025-08-01
|
| Series: | Clinical and Experimental Pediatrics |
| Subjects: | |
| Online Access: | http://www.e-cep.org/upload/pdf/cep-2025-00262.pdf |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849397296343547904 |
|---|---|
| author | Wael A. Bahbah Yasmin A.H.S. Younis Hanan Salama Elbelouny Asmaa A. Mahmoud |
| author_facet | Wael A. Bahbah Yasmin A.H.S. Younis Hanan Salama Elbelouny Asmaa A. Mahmoud |
| author_sort | Wael A. Bahbah |
| collection | DOAJ |
| description | Background Liposomal iron, a novel oral formulation of ferric pyrophosphate that demonstrates improved gastrointestinal absorption and bioavailability with fewer side effects than conventional iron, represents a significant advancement in the treatment of iron-deficiency anemia (IDA). Purpose To conduct an in-depth comparative study of liposomal SunActive and conventional iron supplements (iron polymaltose complex) for treating IDA in children aged 2–12 years Methods This prospective randomized controlled trial included 192 children who visited the outpatient clinic of the Pediatric Department at Menoufia University Hospital and were diagnosed with IDA. The patients were divided into group 1, 96 pediatric patients receiving oral liposomal SunActive iron; and group 2, 96 pediatric patients treated with conventional oral iron (iron polymaltose complex). Results After 1 month of oral iron therapy, group 1 exhibited higher hemoglobin, hematocrit, serum ferritin, and serum iron levels and greater transferrin saturation than group 2. After 6 months of oral iron therapy, hemoglobin level (P<0.001), iron profile (P<0.001), and growth-related anthropometric measurements were higher in group 1 versus group 2 (P<0.001for z score for weight). Conclusion Iron supplements effectively improve anthropometric measurements, complete blood count parameters, and iron profiles. However, orally administered liposomal SunActive iron exhibits better effects, reduced drug refusal rates, and improved compliance rates, thereby benefiting children's growth. |
| format | Article |
| id | doaj-art-d9231a47dd4a47ecb39b722ebcdc15c0 |
| institution | Kabale University |
| issn | 2713-4148 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | The Korean Pediatric Society |
| record_format | Article |
| series | Clinical and Experimental Pediatrics |
| spelling | doaj-art-d9231a47dd4a47ecb39b722ebcdc15c02025-08-20T03:39:04ZengThe Korean Pediatric SocietyClinical and Experimental Pediatrics2713-41482025-08-0168860861510.3345/cep.2025.0026220125555828Liposomal SunActive versus conventional iron for treatment of iron-deficiency anemia in children aged 2–12 years: a prospective randomized controlled trialWael A. Bahbah0Yasmin A.H.S. Younis1Hanan Salama Elbelouny2Asmaa A. Mahmoud3 Department of Pediatrics, Faculty of Medicine - Menoufia University, Shebin El-Kom, Egypt Department of Clinical Pathology, Faculty of Medicine – Menoufia University, Shebin El-Kom, Egypt Egyptian Ministry of Health, Cairo, Egypt Department of Pediatrics, Faculty of Medicine - Menoufia University, Shebin El-Kom, EgyptBackground Liposomal iron, a novel oral formulation of ferric pyrophosphate that demonstrates improved gastrointestinal absorption and bioavailability with fewer side effects than conventional iron, represents a significant advancement in the treatment of iron-deficiency anemia (IDA). Purpose To conduct an in-depth comparative study of liposomal SunActive and conventional iron supplements (iron polymaltose complex) for treating IDA in children aged 2–12 years Methods This prospective randomized controlled trial included 192 children who visited the outpatient clinic of the Pediatric Department at Menoufia University Hospital and were diagnosed with IDA. The patients were divided into group 1, 96 pediatric patients receiving oral liposomal SunActive iron; and group 2, 96 pediatric patients treated with conventional oral iron (iron polymaltose complex). Results After 1 month of oral iron therapy, group 1 exhibited higher hemoglobin, hematocrit, serum ferritin, and serum iron levels and greater transferrin saturation than group 2. After 6 months of oral iron therapy, hemoglobin level (P<0.001), iron profile (P<0.001), and growth-related anthropometric measurements were higher in group 1 versus group 2 (P<0.001for z score for weight). Conclusion Iron supplements effectively improve anthropometric measurements, complete blood count parameters, and iron profiles. However, orally administered liposomal SunActive iron exhibits better effects, reduced drug refusal rates, and improved compliance rates, thereby benefiting children's growth.http://www.e-cep.org/upload/pdf/cep-2025-00262.pdfliposomal sunactive ironconventional ironiron-deficiency anemia |
| spellingShingle | Wael A. Bahbah Yasmin A.H.S. Younis Hanan Salama Elbelouny Asmaa A. Mahmoud Liposomal SunActive versus conventional iron for treatment of iron-deficiency anemia in children aged 2–12 years: a prospective randomized controlled trial Clinical and Experimental Pediatrics liposomal sunactive iron conventional iron iron-deficiency anemia |
| title | Liposomal SunActive versus conventional iron for treatment of iron-deficiency anemia in children aged 2–12 years: a prospective randomized controlled trial |
| title_full | Liposomal SunActive versus conventional iron for treatment of iron-deficiency anemia in children aged 2–12 years: a prospective randomized controlled trial |
| title_fullStr | Liposomal SunActive versus conventional iron for treatment of iron-deficiency anemia in children aged 2–12 years: a prospective randomized controlled trial |
| title_full_unstemmed | Liposomal SunActive versus conventional iron for treatment of iron-deficiency anemia in children aged 2–12 years: a prospective randomized controlled trial |
| title_short | Liposomal SunActive versus conventional iron for treatment of iron-deficiency anemia in children aged 2–12 years: a prospective randomized controlled trial |
| title_sort | liposomal sunactive versus conventional iron for treatment of iron deficiency anemia in children aged 2 12 years a prospective randomized controlled trial |
| topic | liposomal sunactive iron conventional iron iron-deficiency anemia |
| url | http://www.e-cep.org/upload/pdf/cep-2025-00262.pdf |
| work_keys_str_mv | AT waelabahbah liposomalsunactiveversusconventionalironfortreatmentofirondeficiencyanemiainchildrenaged212yearsaprospectiverandomizedcontrolledtrial AT yasminahsyounis liposomalsunactiveversusconventionalironfortreatmentofirondeficiencyanemiainchildrenaged212yearsaprospectiverandomizedcontrolledtrial AT hanansalamaelbelouny liposomalsunactiveversusconventionalironfortreatmentofirondeficiencyanemiainchildrenaged212yearsaprospectiverandomizedcontrolledtrial AT asmaaamahmoud liposomalsunactiveversusconventionalironfortreatmentofirondeficiencyanemiainchildrenaged212yearsaprospectiverandomizedcontrolledtrial |