PSA DENSITY - A MARKER FOR POORLY-DIFFERENTIATED PROSTATE CANCER
Purpose: The present study examines the relationship between Prostate-Specific Antigen Density (PSAD) and the degree of differentiation of prostate cancer, as determined by the Gleason score. Material/Methods: A single-center study was conducted. We analyzed 155 patients who had had surgeries at th...
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| Main Author: | |
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| Format: | Article |
| Language: | English |
| Published: |
Peytchinski Publishing
2025-02-01
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| Series: | Journal of IMAB |
| Subjects: | |
| Online Access: | https://www.journal-imab-bg.org/issues-2025/issue1/2025vol31-issue1-6009-6012.pdf |
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| Summary: | Purpose: The present study examines the relationship between Prostate-Specific Antigen Density (PSAD) and the degree of differentiation of prostate cancer, as determined by the Gleason score.
Material/Methods: A single-center study was conducted. We analyzed 155 patients who had had surgeries at the Urology Clinic of Saint Anna Hospital in Varna.
Results: We found that an elevated PSAD - especially above 0.15 ng/ml2 – increases the probability of detecting a poorly-differentiated cancer (with a high Gleason score) with unfavorable features from the pathological report after the radical prostatectomy (seminal vesicle involvement, lymph node metastases and extraprostatic tumor extension).
Conclusions: PSAD is a valid tool which correctly predicts the unfavorable pathology of the removed specimen. |
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| ISSN: | 1312-773X |