Vitamin B6 Prevents Endothelial Dysfunction, Insulin Resistance, and Hepatic Lipid Accumulation in Apoe−/− Mice Fed with High-Fat Diet
Backgrounds. VitB6 deficiency has been associated with a number of adverse health effects. However, the effects of VitB6 in metabolic syndrome are poorly understood. Methods. VitB6 (50 mg/kg/day) was given to Apoe-/- mice with hkdigh-fat diet (HFD) for 8 weeks. Endothelial dysfunction, insulin resis...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2016/1748065 |
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| _version_ | 1850168344793055232 |
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| author | Zhan Liu Peng Li Zhi-Hong Zhao Yu Zhang Zhi-Min Ma Shuang-Xi Wang |
| author_facet | Zhan Liu Peng Li Zhi-Hong Zhao Yu Zhang Zhi-Min Ma Shuang-Xi Wang |
| author_sort | Zhan Liu |
| collection | DOAJ |
| description | Backgrounds. VitB6 deficiency has been associated with a number of adverse health effects. However, the effects of VitB6 in metabolic syndrome are poorly understood. Methods. VitB6 (50 mg/kg/day) was given to Apoe-/- mice with hkdigh-fat diet (HFD) for 8 weeks. Endothelial dysfunction, insulin resistance, and hepatic lipid contents were determined. Results. VitB6 administration remarkably increased acetylcholine-induced endothelium-dependent relaxation and decreased random blood glucose level in Apoe-/- mice fed with HFD. In addition, VitB6 improved the tolerance of glucose and insulin, normalized the histopathology of liver, and reduced hepatic lipid accumulation but did not affect the liver functions. Clinical and biochemical analysis indicated that the levels of VitB6 were decreased in patients with fatty liver. Conclusions. Vitamin B6 prevents endothelial dysfunction, insulin resistance, and hepatic lipid accumulation in Apoe-/- mice fed with HFD. Supplementation of VitB6 should be considered to prevent metabolic syndrome. |
| format | Article |
| id | doaj-art-d9161db4ca104afabbe739162afccc0e |
| institution | OA Journals |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-d9161db4ca104afabbe739162afccc0e2025-08-20T02:20:58ZengWileyJournal of Diabetes Research2314-67452314-67532016-01-01201610.1155/2016/17480651748065Vitamin B6 Prevents Endothelial Dysfunction, Insulin Resistance, and Hepatic Lipid Accumulation in Apoe−/− Mice Fed with High-Fat DietZhan Liu0Peng Li1Zhi-Hong Zhao2Yu Zhang3Zhi-Min Ma4Shuang-Xi Wang5Department of Clinical Nutrition and Gastroenterology, The First Affiliated Hospital (People’s Hospital of Hunan Province), Hunan Normal University, Changsha 430070, ChinaCollege of Pharmacy, Xinxiang Medical University, Xinxiang 453003, ChinaDepartment of Clinical Nutrition and Gastroenterology, The First Affiliated Hospital (People’s Hospital of Hunan Province), Hunan Normal University, Changsha 430070, ChinaDepartment of Clinical Nutrition and Gastroenterology, The First Affiliated Hospital (People’s Hospital of Hunan Province), Hunan Normal University, Changsha 430070, ChinaDivision of Endocrinology, The Second Affiliated Hospital, Soochow University, Suzhou 215000, ChinaCollege of Pharmacy, Xinxiang Medical University, Xinxiang 453003, ChinaBackgrounds. VitB6 deficiency has been associated with a number of adverse health effects. However, the effects of VitB6 in metabolic syndrome are poorly understood. Methods. VitB6 (50 mg/kg/day) was given to Apoe-/- mice with hkdigh-fat diet (HFD) for 8 weeks. Endothelial dysfunction, insulin resistance, and hepatic lipid contents were determined. Results. VitB6 administration remarkably increased acetylcholine-induced endothelium-dependent relaxation and decreased random blood glucose level in Apoe-/- mice fed with HFD. In addition, VitB6 improved the tolerance of glucose and insulin, normalized the histopathology of liver, and reduced hepatic lipid accumulation but did not affect the liver functions. Clinical and biochemical analysis indicated that the levels of VitB6 were decreased in patients with fatty liver. Conclusions. Vitamin B6 prevents endothelial dysfunction, insulin resistance, and hepatic lipid accumulation in Apoe-/- mice fed with HFD. Supplementation of VitB6 should be considered to prevent metabolic syndrome.http://dx.doi.org/10.1155/2016/1748065 |
| spellingShingle | Zhan Liu Peng Li Zhi-Hong Zhao Yu Zhang Zhi-Min Ma Shuang-Xi Wang Vitamin B6 Prevents Endothelial Dysfunction, Insulin Resistance, and Hepatic Lipid Accumulation in Apoe−/− Mice Fed with High-Fat Diet Journal of Diabetes Research |
| title | Vitamin B6 Prevents Endothelial Dysfunction, Insulin Resistance, and Hepatic Lipid Accumulation in Apoe−/− Mice Fed with High-Fat Diet |
| title_full | Vitamin B6 Prevents Endothelial Dysfunction, Insulin Resistance, and Hepatic Lipid Accumulation in Apoe−/− Mice Fed with High-Fat Diet |
| title_fullStr | Vitamin B6 Prevents Endothelial Dysfunction, Insulin Resistance, and Hepatic Lipid Accumulation in Apoe−/− Mice Fed with High-Fat Diet |
| title_full_unstemmed | Vitamin B6 Prevents Endothelial Dysfunction, Insulin Resistance, and Hepatic Lipid Accumulation in Apoe−/− Mice Fed with High-Fat Diet |
| title_short | Vitamin B6 Prevents Endothelial Dysfunction, Insulin Resistance, and Hepatic Lipid Accumulation in Apoe−/− Mice Fed with High-Fat Diet |
| title_sort | vitamin b6 prevents endothelial dysfunction insulin resistance and hepatic lipid accumulation in apoe mice fed with high fat diet |
| url | http://dx.doi.org/10.1155/2016/1748065 |
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