Changes in Macular Pigment Optical Density as a New Risk Factor for Primary Open-angle Glaucoma
With aging, the prevalence of eye diseases such as primary open-angle glaucoma (POAG) and age-related macular degeneration (AMD) increases, making them leading causes of vision loss in older adults. Recent studies suggest that a decrease in macular pigment optical density (MPOD), composed of lutein,...
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| Format: | Article |
| Language: | Russian |
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Ophthalmology Publishing Group
2025-06-01
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| Series: | Oftalʹmologiâ |
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| Online Access: | https://www.ophthalmojournal.com/opht/article/view/2666 |
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| author | I. A. Loskutov O. M. Andryukhina |
| author_facet | I. A. Loskutov O. M. Andryukhina |
| author_sort | I. A. Loskutov |
| collection | DOAJ |
| description | With aging, the prevalence of eye diseases such as primary open-angle glaucoma (POAG) and age-related macular degeneration (AMD) increases, making them leading causes of vision loss in older adults. Recent studies suggest that a decrease in macular pigment optical density (MPOD), composed of lutein, zeaxanthin, and meso-zeaxanthin, may be associated with an increased risk of POAG. These carotenoids play a crucial role in protecting photoreceptors from oxidative stress, regulating light filtration, and providing neuroprotection. Studies have shown that patients with POAG exhibit lower MPOD levels, which may serve as an early biomarker of glaucomatous neurodegeneration. Moreover, supplementation with macular carotenoids has been found to increase MPOD, potentially improving visual function. Additionally, B vitamins and niacin offer further protection by supporting mitochondrial health and reducing oxidative stress in retinal ganglion cells. Thus, investigating MPOD as a modifiable risk factor for POAG presents new opportunities for disease diagnosis and management. Further research is needed to determine optimal nutraceutical strategies and to evaluate the impact of MPOD on glaucoma progression. |
| format | Article |
| id | doaj-art-d90d0ba8cbf448d9a15ffd2c923fcbab |
| institution | DOAJ |
| issn | 1816-5095 2500-0845 |
| language | Russian |
| publishDate | 2025-06-01 |
| publisher | Ophthalmology Publishing Group |
| record_format | Article |
| series | Oftalʹmologiâ |
| spelling | doaj-art-d90d0ba8cbf448d9a15ffd2c923fcbab2025-08-20T03:22:19ZrusOphthalmology Publishing GroupOftalʹmologiâ1816-50952500-08452025-06-0122237638210.18008/1816-5095-2025-2-376-3821270Changes in Macular Pigment Optical Density as a New Risk Factor for Primary Open-angle GlaucomaI. A. Loskutov0O. M. Andryukhina1Moscow Regional Research and Clinical Institute (MONIKI)Moscow Regional Research and Clinical Institute (MONIKI)With aging, the prevalence of eye diseases such as primary open-angle glaucoma (POAG) and age-related macular degeneration (AMD) increases, making them leading causes of vision loss in older adults. Recent studies suggest that a decrease in macular pigment optical density (MPOD), composed of lutein, zeaxanthin, and meso-zeaxanthin, may be associated with an increased risk of POAG. These carotenoids play a crucial role in protecting photoreceptors from oxidative stress, regulating light filtration, and providing neuroprotection. Studies have shown that patients with POAG exhibit lower MPOD levels, which may serve as an early biomarker of glaucomatous neurodegeneration. Moreover, supplementation with macular carotenoids has been found to increase MPOD, potentially improving visual function. Additionally, B vitamins and niacin offer further protection by supporting mitochondrial health and reducing oxidative stress in retinal ganglion cells. Thus, investigating MPOD as a modifiable risk factor for POAG presents new opportunities for disease diagnosis and management. Further research is needed to determine optimal nutraceutical strategies and to evaluate the impact of MPOD on glaucoma progression.https://www.ophthalmojournal.com/opht/article/view/2666macular pigmentsoptical density of macular pigmentluteinzeaxanthinglaucomaage-related macular degeneration |
| spellingShingle | I. A. Loskutov O. M. Andryukhina Changes in Macular Pigment Optical Density as a New Risk Factor for Primary Open-angle Glaucoma Oftalʹmologiâ macular pigments optical density of macular pigment lutein zeaxanthin glaucoma age-related macular degeneration |
| title | Changes in Macular Pigment Optical Density as a New Risk Factor for Primary Open-angle Glaucoma |
| title_full | Changes in Macular Pigment Optical Density as a New Risk Factor for Primary Open-angle Glaucoma |
| title_fullStr | Changes in Macular Pigment Optical Density as a New Risk Factor for Primary Open-angle Glaucoma |
| title_full_unstemmed | Changes in Macular Pigment Optical Density as a New Risk Factor for Primary Open-angle Glaucoma |
| title_short | Changes in Macular Pigment Optical Density as a New Risk Factor for Primary Open-angle Glaucoma |
| title_sort | changes in macular pigment optical density as a new risk factor for primary open angle glaucoma |
| topic | macular pigments optical density of macular pigment lutein zeaxanthin glaucoma age-related macular degeneration |
| url | https://www.ophthalmojournal.com/opht/article/view/2666 |
| work_keys_str_mv | AT ialoskutov changesinmacularpigmentopticaldensityasanewriskfactorforprimaryopenangleglaucoma AT omandryukhina changesinmacularpigmentopticaldensityasanewriskfactorforprimaryopenangleglaucoma |